Published in Brain Res on November 24, 2000
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A (2002) 3.05
Force transduction by Triton cytoskeletons. J Cell Biol (2002) 2.83
Neurosensory mechanotransduction. Nat Rev Mol Cell Biol (2009) 2.73
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc Natl Acad Sci U S A (2001) 1.75
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis. Hypertension (2008) 1.37
Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proc Natl Acad Sci U S A (2003) 1.33
ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch (2005) 1.30
Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. J Physiol (2009) 1.26
Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus. J Physiol (2003) 1.22
How we feel: ion channel partnerships that detect mechanical inputs and give rise to touch and pain perception. Neuron (2012) 1.14
Inhibition of mechanical activation of guinea-pig airway afferent neurons by amiloride analogues. Br J Pharmacol (2001) 1.05
Pharmacology of airway afferent nerve activity. Respir Res (2001) 0.97
Sodium channels and mammalian sensory mechanotransduction. Mol Pain (2012) 0.91
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
Mechano-sensitivity of ENaC: may the (shear) force be with you. Pflugers Arch (2007) 0.91
Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles. Cell Mol Neurobiol (2010) 0.89
Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Adv Genet (2011) 0.88
Worm sensation! Mol Pain (2005) 0.88
Role of the epithelial sodium channel in salt-sensitive hypertension. Acta Pharmacol Sin (2011) 0.88
βENaC is a molecular component of a VSMC mechanotransducer that contributes to renal blood flow regulation, protection from renal injury, and hypertension. Front Physiol (2012) 0.85
Cell mechanosensitivity: mechanical properties and interaction with gravitational field. Biomed Res Int (2012) 0.84
Placental ischemia impairs middle cerebral artery myogenic responses in the pregnant rat. Hypertension (2011) 0.83
Overexpression of the epithelial Na+ channel gamma subunit in collecting duct cells: interactions of Liddle's mutations and steroids on expression and function. J Biol Chem (2005) 0.83
Inhibitory effect of amiloride and gadolinium on fine afferent nerves in the rat knee: evidence of mechanogated ion channels in joints. Exp Brain Res (2005) 0.83
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci (2016) 0.79
Neuromodulation in the spiral ganglion: shaping signals from the organ of corti to the CNS. J Membr Biol (2006) 0.78
Expression of AmphiNaC, a new member of the amiloride-sensitive sodium channel related to degenerins and epithelial sodium channels in amphioxus. Int J Biol Sci (2006) 0.77
Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res (2014) 0.75
βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. J Nephrol Res (2015) 0.75
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature (2000) 10.32
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature (1992) 8.47
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell (1996) 6.84
Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest (1995) 6.64
Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med (1993) 5.85
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science (1991) 5.82
Structure and function of the CFTR chloride channel. Physiol Rev (1999) 4.82
Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem (1995) 4.39
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature (1990) 4.26
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell (1991) 3.75
The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron (2001) 3.56
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell (1993) 3.47
Generation of cAMP-activated chloride currents by expression of CFTR. Science (1991) 3.45
Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties. Nature (1993) 3.43
The mammalian sodium channel BNC1 is required for normal touch sensation. Nature (2000) 3.30
Nucleoside triphosphates are required to open the CFTR chloride channel. Cell (1991) 3.21
Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J Biol Chem (2001) 3.15
Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature (1990) 3.09
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature (1988) 3.06
Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J Biol Chem (1999) 3.04
Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells. Proc Natl Acad Sci U S A (1978) 3.03
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity. J Biol Chem (1995) 2.88
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68
Crypts are the site of intestinal fluid and electrolyte secretion. Science (1982) 2.66
Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Chem (1994) 2.56
Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol (2000) 2.55
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. J Gen Physiol (1992) 2.53
Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. J Clin Invest (1998) 2.51
Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation (1997) 2.49
A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest (1995) 2.48
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell (1995) 2.47
Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel. Am J Physiol (1995) 2.38
Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. J Cell Biol (1979) 2.35
Chloride and potassium channels in cystic fibrosis airway epithelia. Nature (1986) 2.34
Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection. J Clin Invest (1997) 2.33
Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Mol Cell (1998) 2.31
Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia. Proc Natl Acad Sci U S A (1991) 2.30
Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2. Mol Cell Biol (1991) 2.25
Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24
cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia. J Clin Invest (1992) 2.23
Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Science (1992) 2.18
Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A (1988) 2.15
Cloning and expression of a novel human brain Na+ channel. J Biol Chem (1996) 2.14
Effect of deleting the R domain on CFTR-generated chloride channels. Science (1991) 2.09
Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel. Am J Physiol (1994) 2.07
Isolation, characterization, and localization of the inositol 1,4,5-trisphosphate receptor protein in Xenopus laevis oocytes. J Biol Chem (1992) 2.05
Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol (1985) (1989) 2.04
Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation. Biophys J (1994) 1.99
Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J Virol (1996) 1.98
Activity of abundant antimicrobials of the human airway. Am J Respir Cell Mol Biol (1999) 1.93
Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest (1991) 1.93
Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia. J Clin Invest (1992) 1.93
Selective beta-1 receptor blockade with oral practolol in man. A dose-related phenomenon. J Clin Invest (1975) 1.91
Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol (1985) (1989) 1.91
A molecular component of the arterial baroreceptor mechanotransducer. Neuron (1998) 1.87
Calcium-activated potassium channels in canine airway smooth muscle. J Physiol (1986) 1.87
Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium. Proc Natl Acad Sci U S A (1985) 1.87
A simplified neck suction device for activation of carotid baroreceptors. J Lab Clin Med (1975) 1.82
Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J Cell Biol (1998) 1.82
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron (2000) 1.81
Effects of adrenergic stimulation on ventilation in man. J Clin Invest (1972) 1.80
Ca2+-dependent regulator. Production and characterization of a monospecific antibody. J Biol Chem (1978) 1.80
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain. J Biol Chem (1993) 1.80
Chloride secretion by canine tracheal epithelium: I. Role of intracellular c AMP levels. J Membr Biol (1982) 1.79
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases. J Biol Chem (1993) 1.77
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc Natl Acad Sci U S A (2001) 1.75
Chloride secretion by canine tracheal epithelium: II. The cellular electrical potential profile. J Membr Biol (1982) 1.74
Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast. Cell (1993) 1.72
Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Hum Gene Ther (1993) 1.72
Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J Clin Invest (1991) 1.71
An apical-membrane chloride channel in human tracheal epithelium. Science (1986) 1.71
Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis. Am J Respir Crit Care Med (1995) 1.70
Stimulation of CFTR activity by its phosphorylated R domain. Nature (1997) 1.68
Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia. J Cell Biol (1992) 1.68
HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells. Am J Physiol (1999) 1.67
Inhibition of chloride secretion by furosemide in canine tracheal epithelium. J Membr Biol (1983) 1.67
Ca2+ and cyclic AMP in regulation of intestinal Na, K, and Cl transport. Annu Rev Physiol (1986) 1.65
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nat Genet (1993) 1.63
The role of low pressure baroreceptors in reflex vasoconstrictor responses in man. J Clin Invest (1972) 1.59
Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. Am J Physiol (1992) 1.58
Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. J Biol Chem (1997) 1.57
Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension (1988) 1.56
Female condom introduction and sexually transmitted infection prevalence: results of a community intervention trial in Kenya. AIDS (2001) 1.55
The distribution of calmodulin in living mitotic cells. Exp Cell Res (1983) 1.54
Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci U S A (1999) 1.53
Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. J Biol Chem (1999) 1.53
Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest (1974) 1.50
Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J Biol Chem (1998) 1.49
Reflex control of the peripheral circulation. Prog Cardiovasc Dis (1976) 1.47
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain. J Biol Chem (2001) 1.43
Block by MOPS reveals a conformation change in the CFTR pore produced by ATP hydrolysis. Am J Physiol (1997) 1.39
Contrasting effects of static and pulsatile pressure on carotid baroreceptor activity in dogs. Circ Res (1987) 1.39
Inositol trisphosphate isomers, but not inositol 1,3,4,5-tetrakisphosphate, induce calcium influx in Xenopus laevis oocytes. J Biol Chem (1988) 1.39
Identification and regulation of whole-cell chloride currents in airway epithelium. J Gen Physiol (1989) 1.38
Dickinson W. Richards Lecture: Circulatory adjustments to hypoxia. Circulation (1980) 1.38
Number of subunits comprising the epithelial sodium channel. J Biol Chem (1999) 1.38
Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines. Am J Physiol (1990) 1.35
Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro. J Biol Chem (1994) 1.35