Death, autoantigen modifications, and tolerance.

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Published in Arthritis Res on February 09, 2000

Authors

P J Utz1, T J Gensler, P Anderson

Author Affiliations

1: Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. pjutz@stanford.edu

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Learning by internal medicine residents: differences and similarities of perceptions by residents and faculty. J Gen Intern Med (1995) 1.69

Managing alcohol problems in general practice. Br Med J (Clin Res Ed) (1985) 1.69

Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J Biol Chem (1999) 1.69

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Isolation of the capsular polysaccharide from culture supernatant of Haemophilus influenzae type b. Infect Immun (1977) 1.40

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Interchangeability of conjugated Haemophilus influenzae type b vaccines in infants. JAMA (1995) 1.40

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Multiple carpo-metacarpal dislocations. J Hand Surg Br (1989) 1.39

The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum. Br J Cancer Suppl (1978) 1.38

Mode of activation of hippocampal pyramidal cells by excitatory synapses on dendrites. Exp Brain Res (1966) 1.38

Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. J Biol Chem (1998) 1.38