Published in Nature on November 16, 2000
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev (2001) 21.82
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol (2000) 9.01
A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Res (2002) 5.93
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A (2004) 5.54
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52
FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol (2007) 5.23
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J (2003) 5.11
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
Large-scale discovery of induced point mutations with high-throughput TILLING. Genome Res (2003) 4.39
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35
WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res (2004) 4.14
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
Insertional mutagenesis of genes required for seed development in Arabidopsis thaliana. Genetics (2001) 3.49
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science (2004) 3.48
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
A first version of the Caenorhabditis elegans Promoterome. Genome Res (2004) 3.29
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks. Genome Biol (2005) 3.24
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
High-throughput gene mapping in Caenorhabditis elegans. Genome Res (2002) 3.21
Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A (2004) 2.98
Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2002) 2.85
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol (2006) 2.83
Identification of genes required for embryo development in Arabidopsis. Plant Physiol (2004) 2.81
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
Derivation of genetic interaction networks from quantitative phenotype data. Genome Biol (2005) 2.74
A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64
Defining the mammalian CArGome. Genome Res (2005) 2.59
Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci U S A (2003) 2.56
C elegans: a model for exploring the genetics of fat storage. Dev Cell (2003) 2.56
Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods (2010) 2.50
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A (2003) 2.44
Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line. Mol Cell Biol (2004) 2.44
Functional genomic analysis of C. elegans molting. PLoS Biol (2005) 2.39
Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis. Cell (2009) 2.33
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics (2006) 2.29
The million mutation project: a new approach to genetics in Caenorhabditis elegans. Genome Res (2013) 2.20
RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev (2003) 2.19
Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol (2007) 2.19
Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev (2001) 2.19
Protein stability imposes limits on organism complexity and speed of molecular evolution. Proc Natl Acad Sci U S A (2007) 2.16
Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics. J Cell Biol (2002) 2.15
Short defective interfering RNAs of tombusviruses are not targeted but trigger post-transcriptional gene silencing against their helper virus. Plant Cell (2002) 2.12
Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Mol Biol Cell (2003) 2.12
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev Cell (2007) 2.11
Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. Genome Biol (2003) 2.10
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem (2005) 2.07
OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One (2011) 2.05
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
The draft genome of the parasitic nematode Trichinella spiralis. Nat Genet (2011) 2.03
KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol (2009) 1.97
siRNA relieves chronic neuropathic pain. Nucleic Acids Res (2004) 1.96
The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol (2007) 1.89
Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2001) 1.88
Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy. EMBO J (2001) 1.85
Processing of 20S pre-rRNA to 18S ribosomal RNA in yeast requires Rrp10p, an essential non-ribosomal cytoplasmic protein. EMBO J (2001) 1.85
Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev (2007) 1.85
Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. Mol Cell Biol (2003) 1.85
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics (2007) 1.82
Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nat Methods (2010) 1.82
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
A global analysis of genetic interactions in Caenorhabditis elegans. J Biol (2007) 1.78
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans. Mol Biol Cell (2002) 1.77
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects. Nucleic Acids Res (2004) 1.74
Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. Genome Biol (2007) 1.73
The Arabidopsis SeedGenes Project. Nucleic Acids Res (2003) 1.73
Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans. Dev Cell (2011) 1.71
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell (2002) 1.69
Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. EMBO J (2005) 1.69
E-RNAi: a web application to design optimized RNAi constructs. Nucleic Acids Res (2005) 1.69
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity. Proc Natl Acad Sci U S A (2006) 1.68
Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis. Nat Cell Biol (2009) 1.68
WorfDB: the Caenorhabditis elegans ORFeome Database. Nucleic Acids Res (2003) 1.65
ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans. PLoS Genet (2008) 1.64
Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A (2002) 1.63
Identification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE. BMC Genomics (2009) 1.63
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Genome Biol (2001) 1.61
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev (2002) 1.60
A computational study of off-target effects of RNA interference. Nucleic Acids Res (2005) 1.60
Quantitative classification and natural clustering of Caenorhabditis elegans behavioral phenotypes. Genetics (2003) 1.59
Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev Cell (2008) 1.59
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog (2011) 1.59
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response. Proc Natl Acad Sci U S A (2009) 1.58
Conservation and functional significance of gene topology in the genome of Caenorhabditis elegans. Genome Res (2006) 1.56
The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Genome Biol (2004) 1.55
In vivo RNAi: today and tomorrow. Cold Spring Harb Perspect Biol (2010) 1.55
Analysis of homologous gene clusters in Caenorhabditis elegans reveals striking regional cluster domains. Genetics (2005) 1.55
Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Genome Biol (2007) 1.55
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol (2000) 9.01
The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe. Genes Dev (1997) 2.05
Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos. Nat Cell Biol (2001) 2.02
G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. Cell (1996) 1.86
Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy. EMBO J (2001) 1.85
CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr Biol (2001) 1.82
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr Biol (2000) 1.75
The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning. Development (1999) 1.70
The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation. J Cell Sci (2000) 1.37
Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death Differ (2004) 1.29
PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans. J Cell Sci (1996) 1.16
Repression by the 3' UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. EMBO J (1998) 1.07
Axis determination in C. elegans: initiating and transducing polarity. Curr Opin Genet Dev (2001) 0.97
Mutational and structural analysis of the lectin activity in binding domain 2 of ricin B chain. Protein Eng (1994) 0.80