Published in Proc Natl Acad Sci U S A on August 01, 2006
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95
Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS Pathog (2010) 1.69
Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nat Struct Mol Biol (2009) 1.42
Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila. J Immunol (2012) 1.40
TIS11 family proteins and their roles in posttranscriptional gene regulation. J Biomed Biotechnol (2009) 1.21
Distinct RNA-dependent RNA polymerases are required for RNAi triggered by double-stranded RNA versus truncated transgenes in Paramecium tetraurelia. Nucleic Acids Res (2010) 0.94
The RNA binding protein Tudor-SN is essential for stress tolerance and stabilizes levels of stress-responsive mRNAs encoding secreted proteins in Arabidopsis. Plant Cell (2010) 0.93
Modeling recursive RNA interference. PLoS Comput Biol (2008) 0.89
Search for limiting factors in the RNAi pathway in silkmoth tissues and the Bm5 cell line: the RNA-binding proteins R2D2 and Translin. PLoS One (2011) 0.87
The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels. BMC Mol Biol (2009) 0.85
Proteomics identification of Drosophila small interfering RNA-associated factors. Mol Cell Proteomics (2010) 0.81
HPat a decapping activator interacting with the miRNA effector complex. PLoS One (2013) 0.81
Genome wide screening of RNAi factors of Sf21 cells reveal several novel pathway associated proteins. BMC Genomics (2014) 0.79
Endocytic pathway mediates refractoriness of insect Bactrocera dorsalis to RNA interference. Sci Rep (2015) 0.79
Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. Dev Dyn (2010) 0.79
The Drosophila Tis11 protein and its effects on mRNA expression in flies. J Biol Chem (2014) 0.79
Silencing of genes in cultured Drosophila neurons by RNA interference. Proc Natl Acad Sci U S A (2007) 0.78
AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity. PLoS One (2013) 0.78
Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA Biol (2014) 0.76
Northern blotting. Methods Enzymol (2013) 0.75
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res (1987) 25.34
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev (2001) 21.82
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature (2000) 15.98
Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
miRNAs, cancer, and stem cell division. Cell (2005) 12.15
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science (2001) 11.86
FlyBase: genes and gene models. Nucleic Acids Res (2005) 11.15
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev (1999) 8.21
A protein sensor for siRNA asymmetry. Science (2004) 7.77
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature (2004) 7.63
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev (2002) 6.10
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell (2004) 5.69
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 4.63
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38
Functional genomic analysis of RNA interference in C. elegans. Science (2005) 4.36
A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc Natl Acad Sci U S A (2000) 4.19
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
Assembly and function of RNA silencing complexes. Nat Rev Mol Cell Biol (2005) 3.68
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63
ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A (2002) 3.09
An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome. Genome Biol (2003) 3.08
Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol (2004) 2.47
Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily. Genes Cells (2001) 2.43
Noise amidst the silence: off-target effects of siRNAs? Trends Genet (2004) 2.38
Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem (2006) 1.98
Drosophila argonaute-2 is required early in embryogenesis for the assembly of centric/centromeric heterochromatin, nuclear division, nuclear migration, and germ-cell formation. Genes Dev (2005) 1.77
Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A (2002) 1.63
A novel stop codon readthrough mechanism produces functional Headcase protein in Drosophila trachea. EMBO Rep (2001) 1.32
headcase, an imaginal specific gene required for adult morphogenesis in Drosophila melanogaster. Development (1995) 1.27
Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines. J Mol Biol (1999) 1.08
HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph. J Biol Chem (1998) 0.95
Validation of RNAi silencing specificity using synthetic genes: salicylic acid-binding protein 2 is required for innate immunity in plants. Plant J (2006) 0.91
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet (2004) 11.31
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
The distribution and query systems of the RCSB Protein Data Bank. Nucleic Acids Res (2004) 7.03
Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature (2009) 4.99
Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development (2007) 4.80
miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science (2012) 4.44
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell (2008) 3.58
Intergenic transcription through a polycomb group response element counteracts silencing. Genes Dev (2005) 3.50
An active role for tRNA in decoding beyond codon:anticodon pairing. Science (2005) 3.49
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell (2004) 3.18
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature (2011) 3.15
Hypusine-containing protein eIF5A promotes translation elongation. Nature (2009) 2.99
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell (2006) 2.92
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Dev Cell (2003) 2.75
Fidelity at the molecular level: lessons from protein synthesis. Cell (2009) 2.65
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol (2004) 2.53
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A (2009) 2.43
Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell (2004) 2.40
Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37
The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol (2006) 2.32
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29
Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli. Cell (2012) 2.28
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19
Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science (2010) 2.19
Cost-effectiveness study of three antimalarial drug combinations in Tanzania. PLoS Med (2006) 2.18
Quality control by the ribosome following peptide bond formation. Nature (2008) 2.15
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc Natl Acad Sci U S A (2008) 2.10
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00
Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98
Translation drives mRNA quality control. Nat Struct Mol Biol (2012) 1.97
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93
Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch. Mol Cell Biol (2002) 1.93
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (2011) 1.92
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol (2014) 1.86
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature (2012) 1.86
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86
A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes Dev (2002) 1.85
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev (2012) 1.84
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem (2007) 1.83
Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature (2005) 1.82
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release. Mol Cell (2007) 1.80
Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A (2011) 1.78
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb Perspect Biol (2012) 1.73
Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Mol Cell (2003) 1.71
Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formation. Eukaryot Cell (2003) 1.65
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest (2013) 1.65
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol (2013) 1.64
Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res (2010) 1.63
Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell (2010) 1.59
Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell (2010) 1.57
RNA at the steering wheel. Genome Biol (2006) 1.57
Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol (2003) 1.57
The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity. RNA (2006) 1.53
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol (2004) 1.50
Peptide release on the ribosome: mechanism and implications for translational control. Annu Rev Microbiol (2008) 1.48
Genetic and biochemical definition of the Hedgehog receptor. Genes Dev (2010) 1.47
Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol (2007) 1.45
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal (2011) 1.45
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev Biol (2012) 1.43
Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A (2012) 1.42
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc Natl Acad Sci U S A (2007) 1.41
Nevirapine plus efavirenz plus didanosine: a simple, safe, and effective once-daily regimen for patients with HIV infection. J Natl Med Assoc (2003) 1.41
High incidence of vaginal mesh extrusion using the intravaginal slingplasty sling. J Urol (2005) 1.41
Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol Cell (2007) 1.41
Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol (2010) 1.40
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A (2005) 1.40
A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Dev Cell (2010) 1.38
Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis. Methods (2005) 1.37
Analysis of Dom34 and its function in no-go decay. Mol Biol Cell (2009) 1.37
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome. Nat Struct Mol Biol (2006) 1.33
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem (2012) 1.33