Published in Genome Res on December 01, 2000
Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell (2014) 3.04
PAI-1 in tissue fibrosis. J Cell Physiol (2012) 2.26
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
An overview of the serpin superfamily. Genome Biol (2006) 2.14
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts. Genome Res (2003) 1.92
A serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell (2015) 1.57
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med (2015) 1.49
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med (2005) 1.27
Identification of plasma proteases inhibited by Manduca sexta serpin-4 and serpin-5 and their association with components of the prophenol oxidase activation pathway. J Biol Chem (2005) 1.25
Exosite determinants of serpin specificity. J Biol Chem (2009) 1.23
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood (2010) 1.20
Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidation. J Biol Chem (2005) 1.20
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem (2010) 1.14
Serpins in plants and green algae. Funct Integr Genomics (2007) 1.14
Update of the human and mouse SERPIN gene superfamily. Hum Genomics (2013) 1.12
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood (2009) 1.09
The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates. Proc Natl Acad Sci U S A (2005) 1.09
A survey of host range genes in poxvirus genomes. Infect Genet Evol (2012) 1.05
A comparative analysis of serpin genes in the silkworm genome. Genomics (2009) 1.04
Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response. PLoS Genet (2008) 1.03
L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases. Am J Pathol (2006) 1.03
Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21). J Biol Chem (2010) 0.99
Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis. BMC Genomics (2009) 0.99
Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. BMC Mol Biol (2007) 0.98
Proteomic analysis of cattle tick Rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged females. PLoS One (2014) 0.97
The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep (2007) 0.97
Analysis of vertebrate genomes suggests a new model for clade B serpin evolution. BMC Genomics (2005) 0.97
Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet (2010) 0.96
Characterization of the serpin-encoding gene of Bifidobacterium breve 210B. Appl Environ Microbiol (2010) 0.96
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis. BMC Cancer (2009) 0.94
Manduca sexta serpin-5 regulates prophenoloxidase activation and the Toll signaling pathway by inhibiting hemolymph proteinase HP6. Insect Biochem Mol Biol (2010) 0.94
Serpins in unicellular Eukarya, Archaea, and Bacteria: sequence analysis and evolution. J Mol Evol (2004) 0.93
The serpin gene family in Anopheles gambiae. Gene (2009) 0.92
Amblyomma americanum (L.) (Acari: Ixodidae) tick salivary gland serine protease inhibitor (serpin) 6 is secreted into tick saliva during tick feeding. J Exp Biol (2011) 0.91
Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J (2003) 0.91
How the serpin α1-proteinase inhibitor folds. J Biol Chem (2012) 0.90
Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. Am J Hum Genet (2013) 0.90
Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila melanogaster. Mol Cell Biol (2011) 0.90
Serpin-1 splicing isoform J inhibits the proSpätzle-activating proteinase HP8 to regulate expression of antimicrobial hemolymph proteins in Manduca sexta. Dev Comp Immunol (2010) 0.89
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke. Mol Cell Biol (2004) 0.89
Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mamm Genome (2004) 0.89
Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function. Biochimie (2010) 0.88
Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury. Thromb Haemost (2014) 0.88
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. J Biol Chem (2011) 0.87
Brown spider (Loxosceles genus) venom toxins: tools for biological purposes. Toxins (Basel) (2011) 0.87
Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication. PLoS One (2011) 0.86
Biochemical characterization of Anopheles gambiae SRPN6, a malaria parasite invasion marker in mosquitoes. PLoS One (2012) 0.85
Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment. Biophys J (2012) 0.85
Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands. Biochem J (2003) 0.85
Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. BMC Genomics (2006) 0.84
Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization. J Amino Acids (2011) 0.83
The proteome landscape of Giardia lamblia encystation. PLoS One (2013) 0.83
Crystallization and diffraction analysis of the serpin IRS-2 from the hard tick Ixodes ricinus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.83
Polymerization of human angiotensinogen: insights into its structural mechanism and functional significance. Biochem J (2006) 0.83
Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions. PLoS One (2012) 0.83
Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT. Chromosome Res (2011) 0.83
Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One (2012) 0.83
Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities. J Biol Chem (2017) 0.82
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A (2013) 0.82
Keeping the serpin machine running smoothly. Genome Res (2000) 0.82
Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. BMC Genomics (2009) 0.82
Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics. Biochim Biophys Acta (2014) 0.82
The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity. BMC Biotechnol (2009) 0.82
The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin. PLoS One (2013) 0.82
Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. J Biol Chem (2014) 0.82
An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region. BMC Genomics (2008) 0.81
Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. J Biol Chem (2014) 0.81
Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol (2014) 0.81
A serpin released by an entomopathogen impairs clot formation in insect defense system. PLoS One (2013) 0.80
Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ. Cell Cycle (2011) 0.80
Characterization of a novel serine protease inhibitor gene from a marine metagenome. Mar Drugs (2011) 0.80
PEDF - A Noninhibitory Serpin with Neurotrophic Activity. Acta Naturae (2010) 0.80
The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D. J Biol Chem (2013) 0.80
Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver. Gene Ther (2013) 0.80
Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. J Mol Histol (2013) 0.80
Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum. Parasit Vectors (2014) 0.79
Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem (2012) 0.79
The design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseases. Theor Biol Med Model (2013) 0.79
S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. Cancer Res (2012) 0.79
Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes. J Immunol (2012) 0.79
Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions. Int J Parasitol (2015) 0.79
IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease. PLoS One (2012) 0.79
Serpins in rice: protein sequence analysis, phylogeny and gene expression during development. BMC Genomics (2012) 0.78
A versatile monoclonal antibody specific to human SERPINB5. Hybridoma (Larchmt) (2012) 0.78
Serpin latency transition at atomic resolution. Proc Natl Acad Sci U S A (2014) 0.78
Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance. Biochem J (2016) 0.78
Mechanism of protein-z-mediated inhibition of coagulation factor xa by z-protein-dependent inhibitor: a molecular dynamic approach. ISRN Hematol (2012) 0.77
The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster. J Biol Chem (2012) 0.77
Urochordate serpins are Classified into Six Groups Encoded by Exon-Intron Structures, Microsynteny and Bayesian Phylogenetic Analyses. J Genomics (2014) 0.77
Conformational modification of serpins transforms leukocyte elastase inhibitor into an endonuclease involved in apoptosis. Mol Cell Biol (2007) 0.77
Cellular folding pathway of a metastable serpin. Proc Natl Acad Sci U S A (2016) 0.77
High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. BMC Struct Biol (2014) 0.77
SERPINA2 is a novel gene with a divergent function from SERPINA1. PLoS One (2013) 0.77
Molecular cloning and identification of mouse epididymis-specific gene mHong1, the homologue of rat HongrES1. Asian J Androl (2012) 0.77
Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. PLoS One (2013) 0.77
Molecular characterization of serine protease inhibitor isoform 3, SmSPI, from Schistosoma mansoni. Parasitol Res (2016) 0.76
Identification and characterization of a serine protease inhibitor of Paragonimus westermani. Parasitol Res (2008) 0.76
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