Published in J Biol Chem on May 24, 2010
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat Rev Cancer (2013) 1.31
Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders. Cold Spring Harb Perspect Biol (2011) 1.07
Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition. Proc Natl Acad Sci U S A (2012) 1.04
Identification and function of proteolysis regulators in seminal fluid. Mol Reprod Dev (2012) 1.02
Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One (2012) 1.02
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog (2012) 0.98
Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem (2011) 0.96
A blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting. Int J Parasitol (2014) 0.87
Bioinformatic analyses of male and female Amblyomma americanum tick expressed serine protease inhibitors (serpins). Ticks Tick Borne Dis (2014) 0.85
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem (2012) 0.81
Identification of the main venom protein components of Aphidius ervi, a parasitoid wasp of the aphid model Acyrthosiphon pisum. BMC Genomics (2014) 0.80
Viral serpin therapeutics from concept to clinic. Methods Enzymol (2011) 0.80
Contribution of conserved lysine residues in the alpha2-antiplasmin C terminus to plasmin binding and inhibition. J Biol Chem (2011) 0.79
Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes. Proteins (2011) 0.79
Serpins in rice: protein sequence analysis, phylogeny and gene expression during development. BMC Genomics (2012) 0.78
A versatile monoclonal antibody specific to human SERPINB5. Hybridoma (Larchmt) (2012) 0.78
Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem (2015) 0.78
High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. BMC Struct Biol (2014) 0.77
The pH-dependent Client Release from the Collagen-specific Chaperone HSP47 Is Triggered by a Tandem Histidine Pair. J Biol Chem (2016) 0.77
Serpins in arthropod biology. Semin Cell Dev Biol (2016) 0.76
Structure-function relationship of SW-AT-1, a serpin-type protease inhibitor in silkworm. PLoS One (2014) 0.76
Serine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3. Sci Rep (2017) 0.75
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry (2015) 0.75
The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K. Exp Biol Med (Maywood) (2015) 0.75
The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics (2015) 0.75
α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum. Endoplasmic Reticulum Stress Dis (2016) 0.75
A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP. J Biol Chem (2015) 0.75
Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop. Protein Sci (2015) 0.75
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res (2000) 3.55
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature (2008) 2.88
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol (2004) 2.26
Conformational pathology of the serpins: themes, variations, and therapeutic strategies. Annu Rev Biochem (2009) 2.19
Deposition diseases and 3D domain swapping. Structure (2006) 1.88
Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury. J Clin Invest (2002) 1.84
Characterization of PEDF: a multi-functional serpin family protein. J Cell Biochem (2009) 1.77
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. Nat Struct Biol (2003) 1.76
The functional repertoire of prokaryote cellulosomes includes the serpin superfamily of serine proteinase inhibitors. Mol Microbiol (2006) 1.76
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. EMBO J (2006) 1.59
Biological functions of maspin. J Cell Physiol (2006) 1.54
Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol (2006) 1.47
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A (2002) 1.46
Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. J Biol Chem (2005) 1.44
HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse development. Semin Cell Dev Biol (2003) 1.39
Shape-shifting serpins--advantages of a mobile mechanism. Trends Biochem Sci (2006) 1.37
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
The structure of a Michaelis serpin-protease complex. Nat Struct Biol (2001) 1.27
The Z type variation of human alpha 1-antitrypsin causes a protein folding defect. Nat Struct Biol (1995) 1.26
Exosite determinants of serpin specificity. J Biol Chem (2009) 1.23
Serpins in prokaryotes. Mol Biol Evol (2002) 1.22
Maspin plays an essential role in early embryonic development. Development (2004) 1.13
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood (2009) 1.09
Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights. Eur Respir J (2009) 1.07
Structural mechanism for the carriage and release of thyroxine in the blood. Proc Natl Acad Sci U S A (2006) 1.05
Maspin (SERPINB5) is an obligate intracellular serpin. J Biol Chem (2010) 0.99
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc Natl Acad Sci U S A (2008) 0.98
The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep (2007) 0.97
The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol (2008) 0.94
X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin. Blood (2007) 0.89
The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J Biol Chem (2004) 0.88
Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap. J Biol Chem (2007) 0.86
Immunity-related genes and gene families in Anopheles gambiae. Science (2002) 5.47
Drosophila innate immunity: an evolutionary perspective. Nat Immunol (2002) 4.61
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature (2008) 2.88
Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell (2006) 2.66
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol (2007) 2.36
Activation of Drosophila Toll during fungal infection by a blood serine protease. Science (2002) 2.31
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol (2004) 2.26
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
An overview of the serpin superfamily. Genome Biol (2006) 2.14
Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proc Natl Acad Sci U S A (2002) 2.04
Directing thrombin. Blood (2005) 1.85
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. Nat Struct Biol (2003) 1.76
Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
The immune response of Drosophila melanogaster. Immunol Rev (2004) 1.69
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step. J Biol Chem (2006) 1.66
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One (2010) 1.62
Crystal structure of thrombin bound to heparin. J Biol Chem (2004) 1.61
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. EMBO J (2006) 1.59
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell (2007) 1.56
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol (2008) 1.54
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Blood (2013) 1.53
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway. FASEB J (2005) 1.51
Sensing and signaling during infection in Drosophila. Curr Opin Immunol (2005) 1.49
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. EMBO Rep (2006) 1.49
A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production. BMC Biotechnol (2006) 1.48
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol (2006) 1.47
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A (2002) 1.46
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity (2011) 1.45
Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med (2004) 1.43
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor. Immunity (2009) 1.40
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem (2005) 1.39
Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983. J Immunol (2012) 1.38
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. Proc Natl Acad Sci U S A (2010) 1.38
Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies. Nucleic Acids Res (2003) 1.37
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep (2011) 1.37
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell (2010) 1.36
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem (2009) 1.34
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol (2003) 1.32
A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe (2011) 1.31
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein. J Mol Biol (2007) 1.29
A serpin regulates dorsal-ventral axis formation in the Drosophila embryo. Curr Biol (2003) 1.28
Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6. Cancer Res (2004) 1.24
Thrombin-cofactor interactions: structural insights into regulatory mechanisms. Arterioscler Thromb Vasc Biol (2006) 1.24
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem (2005) 1.21
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe (2013) 1.20
The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem (2005) 1.20
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem (2006) 1.18
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein. Biochemistry (2008) 1.18
Crystal structure of wild-type human thrombin in the Na+-free state. Biochem J (2005) 1.18
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. J Biol Chem (2004) 1.17
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem (2002) 1.17
Enhancing the stability and solubility of TEV protease using in silico design. Protein Sci (2007) 1.17
Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3. Biochem Biophys Res Commun (2004) 1.14
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol (2010) 1.13
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem (2006) 1.13
Update of the human and mouse SERPIN gene superfamily. Hum Genomics (2013) 1.12
Multi-domain misfolding: understanding the aggregation pathway of polyglutamine proteins. Protein Eng Des Sel (2009) 1.12
Extracellular granzymes: current perspectives. Biol Chem (2006) 1.12
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest (2010) 1.11
Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation. Proc Natl Acad Sci U S A (2010) 1.11
The multilayered innate immune defense of the gut. Biomed J (2015) 1.10
The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. PLoS Pathog (2010) 1.10
A central role for Bid in granzyme B-induced apoptosis. J Biol Chem (2004) 1.10
Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation. J Mol Biol (2009) 1.10
Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry (2003) 1.09
Protein expression and refolding--a practical guide to getting the most out of inclusion bodies. Biotechnol Annu Rev (2004) 1.08
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states. J Biol Chem (2010) 1.08
Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease. J Biol Chem (2004) 1.07
Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni. PLoS Pathog (2010) 1.07
Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders. Cold Spring Harb Perspect Biol (2011) 1.07
Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex. Proc Natl Acad Sci U S A (2009) 1.07
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans. Pediatr Res (2009) 1.07
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. J Biol Chem (2004) 1.07
Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes. J Cell Sci (2009) 1.06
Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization. J Mol Biol (2002) 1.06
Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition. Biochemistry (2004) 1.06
Helix D elongation and allosteric activation of antithrombin. J Biol Chem (2001) 1.05