Published in J Biol Chem on December 18, 2000
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol (2008) 3.62
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov (2011) 3.26
CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94
Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis (2008) 2.88
Fibrillins 1 and 2 perform partially overlapping functions during aortic development. J Biol Chem (2005) 2.19
Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol (2009) 1.93
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci (2011) 1.75
A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int (2003) 1.65
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis Tissue Repair (2011) 1.61
Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection. Am J Transplant (2009) 1.59
Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence. J Virol (2003) 1.53
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol (2013) 1.47
The matricellular protein CCN1 is essential for cardiac development. Circ Res (2006) 1.41
The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol (2002) 1.35
Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? J Cell Commun Signal (2009) 1.33
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One (2012) 1.33
The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther (2006) 1.33
Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res (2009) 1.30
CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem (2006) 1.26
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
A role for CCN3 (NOV) in calcium signalling. Mol Pathol (2002) 1.22
Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21
Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol (2006) 1.20
Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Mol Pathol (2001) 1.15
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol (2009) 1.13
Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation. Cell Commun Signal (2005) 1.12
Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci (2008) 1.11
The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr (2011) 1.11
Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta (2013) 1.11
The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis. Histol Histopathol (2010) 1.11
CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network. PLoS One (2011) 1.09
Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation. Mol Biol Cell (2003) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking. Semin Immunopathol (2014) 1.04
TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function. J Cell Biochem (2008) 1.03
Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res (2012) 1.01
CCN3 and calcium signaling. Cell Commun Signal (2003) 1.01
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res (2007) 0.99
Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics (2008) 0.97
The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors. Biomed Res Int (2014) 0.97
Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol (2011) 0.96
A physiological role for connective tissue growth factor in early wound healing. Lab Invest (2012) 0.95
Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Exp Dermatol (2010) 0.94
Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through αVβ3 integrin in human skin fibroblasts. J Biol Chem (2013) 0.93
Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. J Cell Commun Signal (2009) 0.93
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology (2008) 0.93
Extracellular matrix associated protein CYR61 is linked to prostate cancer development. J Urol (2010) 0.92
Proteolysis of CCN1 by plasmin: functional implications. Cancer Res (2005) 0.91
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis (2008) 0.91
G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv (2008) 0.89
Cell surface receptors for CCN proteins. J Cell Commun Signal (2016) 0.86
Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth. PLoS One (2013) 0.85
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. J Cell Sci (2009) 0.85
Novel subdomains of the mouse olfactory bulb defined by molecular heterogeneity in the nascent external plexiform and glomerular layers. BMC Dev Biol (2007) 0.84
Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2011) 0.84
Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF). Trends Dev Biol (2013) 0.83
Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin-mediated cell adhesion. BMC Cell Biol (2010) 0.82
CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. ISRN Gastroenterol (2012) 0.82
Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta1) at the utero-placental interface during early pregnancy in the pig. Mol Pathol (2002) 0.82
CCN notch signaling in vascular smooth muscle cells: good or bad? Arterioscler Thromb Vasc Biol (2010) 0.82
CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy. Int J Mol Med (2015) 0.81
Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury. Histochem Cell Biol (2011) 0.80
Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation. PLoS One (2015) 0.80
The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. J Biol Chem (2015) 0.80
Cytoskeleton reorganization mediates alpha6beta1 integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells. Reprod Biol Endocrinol (2005) 0.78
The extracellular matrix protein CCN1 dictates TNFα and FasL cytotoxicity in vivo. Adv Exp Med Biol (2011) 0.77
Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner. Cell Commun Signal (2013) 0.77
Increased fibroblast functionality on CNN2-loaded titania nanotubes. Int J Nanomedicine (2012) 0.77
Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehyde 3-phosphate dehydrogenase. Int J Legal Med (2008) 0.77
High expression of connective tissue growth factor accelerates dissemination of leukaemia. Oncogene (2016) 0.76
17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in mice. Physiol Rep (2015) 0.76
Cysteine-rich matricellular protein improves callus regenerate in a rabbit trauma model. Int Orthop (2012) 0.76
Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization. PLoS One (2017) 0.75
CCN2 induces cellular senescence in fibroblasts. J Cell Commun Signal (2016) 0.75
Fistulising Crohn's disease: MMPs gone awry. Gut (2004) 0.75
The contribution of adhesion signaling to lactogenesis. J Cell Commun Signal (2010) 0.75
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet (1998) 7.57
A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47
Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci U S A (1987) 7.38
Budding yeast Cdc20: a target of the spindle checkpoint. Science (1998) 6.59
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell (1993) 6.55
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J (1985) 6.31
A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc Natl Acad Sci U S A (1988) 5.25
A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet (1980) 3.82
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci U S A (1988) 3.77
Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol (1991) 3.70
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob Agents Chemother (2000) 3.58
CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci U S A (1998) 3.18
Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition. Mol Cell Biol (2001) 3.10
Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol (1999) 2.67
Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol (1990) 2.64
SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron (1998) 2.63
An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A (1991) 2.44
Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol Cell Biol (1996) 2.44
The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci U S A (1999) 2.41
A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem (1990) 2.39
Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site. Cell (1985) 2.31
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene (1992) 2.17
Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev (1989) 2.17
Synthetic adaptors for cloning DNA. Methods Enzymol (1979) 2.14
The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem (2001) 2.13
SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron (1996) 2.10
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem (2000) 2.07
Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Mol Cell Biol (2000) 2.00
Proposal for a unified CCN nomenclature. Mol Pathol (2003) 1.98
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat Struct Biol (1999) 1.88
Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp Cell Res (1997) 1.88
The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1993) 1.81
Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3. J Biol Chem (1998) 1.78
RNA polymerase pausing and transcript release at the lambda tR1 terminator in vitro. J Biol Chem (1983) 1.71
Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR. Cancer Res (2001) 1.69
A genomic view of the sea urchin nervous system. Dev Biol (2006) 1.68
Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Hum Mol Genet (2001) 1.68
Glutamate-194 to cysteine mutation inhibits fast light-induced proton release in bacteriorhodopsin. Biochemistry (1997) 1.62
Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. J Biol Chem (2000) 1.58
Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface. Cell Growth Differ (1991) 1.55
Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Curr Opin Neurobiol (1998) 1.52
Echographic evaluation of primary cysts of the iris pigment epithelium. Am J Ophthalmol (1995) 1.51
Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J Biol Chem (1999) 1.50
Effect of age on glucose tolerance and glucose uptake in healthy individuals. J Am Geriatr Soc (1989) 1.47
Functional domains and phosphorylation of the orphan receptor Nur77. Mol Endocrinol (1993) 1.46
Report on the second international workshop on the CCN family of genes. Mol Pathol (2003) 1.45
CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. J Biol Chem (2001) 1.43
Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Res (1991) 1.43
Transcription terminates at lambda tR1 in three clusters. Proc Natl Acad Sci U S A (1982) 1.42
Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses. Mol Cell Biol (1993) 1.41
Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol (1997) 1.39
Genomic response to growth factors. Cold Spring Harb Symp Quant Biol (1988) 1.38
Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development. Cell Growth Differ (1992) 1.36
Rho-dependent transcription termination at lambda R1 requires upstream sequences. J Biol Chem (1985) 1.35
A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol (1989) 1.34
ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. Nucleic Acids Res (2001) 1.32
An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle. Oncogene (2007) 1.29
Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. Cancer Gene Ther (2008) 1.26
Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development (2003) 1.26
A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response. J Immunol (2000) 1.25
Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol Cell Biol (1994) 1.22
CCN proteins are distinct from, and should not be considered members of, the insulin-like growth factor-binding protein superfamily. J Clin Endocrinol Metab (2001) 1.21
The Chinese experience of hospital price regulation. Health Policy Plan (2000) 1.20
Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum. J Infect Dis (2001) 1.20
Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem J (1992) 1.20
Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol Cell Biol (1991) 1.18
DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J Biol Chem (2001) 1.18
Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. J Biol Chem (2000) 1.14
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity (2001) 1.14
Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells. J Biol Chem (1993) 1.12
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes. Br J Cancer (1998) 1.12
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem (2001) 1.12
fMRI of visual system activation in the conscious rabbit. Magn Reson Med (2000) 1.11
Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily. Mol Endocrinol (1991) 1.11
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. J Biol Chem (2000) 1.10
Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation. Cancer Res (2001) 1.09
The primary hamster kidney cell rabies vaccine: adaptation of viral strain, production of vaccine, and pre- and postexposure treatment. J Infect Dis (1983) 1.08
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis (2000) 1.08
Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci (2001) 1.08
The majority of duck hepatitis B virus reverse transcriptase in cells is nonencapsidated and is bound to a cytoplasmic structure. J Virol (2000) 1.08
Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells. J Biol Chem (1993) 1.07
BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells. Br J Cancer (1999) 1.07
Cannabinoid-receptor-independent cell signalling by N-acylethanolamines. Biochem J (2001) 1.06
Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein. Oncogene (1993) 1.06
RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J Biol Chem (1993) 1.06
Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene (1998) 1.06
The effects of olanzapine on the 5 dimensions of schizophrenia derived by factor analysis: combined results of the North American and international trials. J Clin Psychiatry (2001) 1.06
A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis. Clin Cancer Res (1999) 1.05
The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene (2010) 1.04
Complete coding sequences of the rabbitpox virus genome. J Gen Virol (2005) 1.04
Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc Natl Acad Sci U S A (1995) 1.03
Human posterior cricoarytenoid muscle compartments. Anatomy and mechanics. Arch Otolaryngol Head Neck Surg (1996) 1.01
Genetic selection of growth-inhibitory sequences in mammalian cells. Proc Natl Acad Sci U S A (1994) 1.01
UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J Biol Chem (2001) 1.01
Integrin-mediated adhesion and signalling in ovarian cancer cells. Cell Signal (1998) 1.00
Isolation of growth suppressors from a cDNA expression library. Oncogene (1998) 1.00
Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors? J Neurosci Res (2004) 1.00
CCN proteins are distinct from and should not be considered members of the insulin-like growth factor-binding protein superfamily. Endocrinology (2000) 0.98