Published in PLoS One on February 20, 2012
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A (2013) 1.88
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 1.51
Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogenesis Tissue Repair (2012) 1.12
Stimulus-induced modulation of transcriptional bursting in a single mammalian gene. Proc Natl Acad Sci U S A (2013) 1.01
CTGF is a therapeutic target for metastatic melanoma. Oncogene (2013) 1.00
PTH promotes allograft integration in a calvarial bone defect. Mol Pharm (2013) 0.99
LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1. Arterioscler Thromb Vasc Biol (2013) 0.96
Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA (2012) 0.95
A physiological role for connective tissue growth factor in early wound healing. Lab Invest (2012) 0.95
CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators. FASEB J (2012) 0.94
Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem (2012) 0.93
The influence of platelet-derived products on angiogenesis and tissue repair: a concise update. Front Physiol (2015) 0.90
Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. J Biol Chem (2013) 0.87
CCN1 and CCN2: blood brothers in angiogenic action. J Cell Commun Signal (2012) 0.86
Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy. J Cell Commun Signal (2013) 0.85
Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF). Trends Dev Biol (2013) 0.83
Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes (2016) 0.81
Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol (2013) 0.81
Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities. Hum Genomics (2015) 0.80
Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis. Haematologica (2014) 0.80
Microvascular targets for anti-fibrotic therapeutics. Yale J Biol Med (2013) 0.78
CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. J Cell Commun Signal (2013) 0.78
Connective Tissue Growth Factor reporter mice label a subpopulation of mesenchymal progenitor cells that reside in the trabecular bone region. Bone (2014) 0.78
Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6. J Am Soc Nephrol (2017) 0.77
Thymosin β4 Improves Differentiation and Vascularization of EHTs. Stem Cells Int (2017) 0.77
Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system. Front Cell Neurosci (2015) 0.77
BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses. PLoS One (2015) 0.75
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis. World J Surg (2016) 0.75
Emerging roles of CCN proteins in vascular development and pathology. J Cell Commun Signal (2016) 0.75
Aortic aneurysm, CCN3 may solve the problem. J Thorac Dis (2016) 0.75
Connective tissue growth factor is involved in structural retinal vascular changes in long-term experimental diabetes. J Histochem Cytochem (2013) 0.75
Extracellular Matrix, a Hard Player in Angiogenesis. Int J Mol Sci (2016) 0.75
PPARG is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target. EMBO Mol Med (2017) 0.75
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The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem (2000) 2.28
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem (1999) 2.18
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Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem (2003) 1.98
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
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CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
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Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem (2000) 1.67
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Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J (2007) 1.62
CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum (2011) 1.46
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett (2006) 1.38
Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. J Clin Endocrinol Metab (2002) 1.34
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Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals. J Cell Commun Signal (2009) 1.30
CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem (2006) 1.26
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro. J Biol Chem (2002) 1.22
CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol (2008) 1.19
Arterial remodeling in vascular disease: a key role for hyaluronan and versican. Front Biosci (2008) 1.18
CTGF expression during mouse embryonic development. Cell Tissue Res (2003) 1.18
Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology (2005) 1.17
Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol (2002) 1.13
Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. FASEB J (2004) 1.10
The first trimester human placenta is a site for terminal maturation of primitive erythroid cells. Blood (2010) 1.09
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol (2011) 1.07
Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. Growth Factors (1999) 1.06
Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome. Exp Cell Res (2001) 1.05
Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts. J Cell Physiol (2007) 1.03
Role of laminins in physiological and pathological angiogenesis. Int J Dev Biol (2011) 1.01
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis. Oncology (2001) 1.00
Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor. Endocrinology (2002) 0.95
Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Development (2011) 0.95
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem (2008) 0.95
Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem (2010) 0.93
Connective tissue growth factor binds to fibronectin through the type I repeat modules and enhances the affinity of fibronectin to fibrin. Biochim Biophys Acta (2006) 0.89
Gene expression of connective tissue growth factor in adult mouse. Growth Factors (2005) 0.82
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09
Autocrine VEGF signaling is required for vascular homeostasis. Cell (2007) 7.37
Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell (2003) 6.38
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol (2005) 4.03
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn (2006) 3.38
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature (2008) 2.47
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
Lineage choice and differentiation in mouse embryos and embryonic stem cells. Dev Biol (2003) 2.27
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2009) 2.26
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell (2010) 2.25
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn (2006) 2.21
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell (2008) 2.13
GDF11 controls the timing of progenitor cell competence in developing retina. Science (2005) 2.04
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01
Notch signaling in blood vessels: who is talking to whom about what? Circ Res (2007) 2.00
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem (2006) 1.96
BMP signaling is required for septation of the outflow tract of the mammalian heart. Development (2003) 1.95
Multiple functions of BMPs in chondrogenesis. J Cell Biochem (2004) 1.92
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol (2010) 1.92
Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nat Med (2002) 1.86
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem (2003) 1.84
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78
Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet (2006) 1.74
A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Sci Signal (2014) 1.67
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. EMBO J (2006) 1.59
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (2006) 1.59
CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res (2006) 1.57
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun (2002) 1.55
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res (2008) 1.51
ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem (2005) 1.45
Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res (2010) 1.45
Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia (2006) 1.44
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A (2005) 1.44
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Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A (2006) 1.34
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development (2005) 1.33
Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo. Circ Res (2003) 1.32
Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res (2010) 1.29
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem (2005) 1.28
Tempting fate: BMP signals for cardiac morphogenesis. Cytokine Growth Factor Rev (2003) 1.26
Notch signaling in vascular morphogenesis. Curr Opin Hematol (2004) 1.25
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endocrinol (2009) 1.24
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood (2012) 1.24
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol (2006) 1.24
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Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn (2006) 1.22
BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci (2010) 1.22
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol (2008) 1.21
CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol (2008) 1.19
Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinoma. Cancer Genet Cytogenet (2007) 1.19
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development (2004) 1.18
Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol (2010) 1.17
Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev (2009) 1.17
Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids. Arterioscler Thromb Vasc Biol (2006) 1.17
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Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood (2010) 1.13
Cellular and molecular regulation of vascular permeability. Thromb Haemost (2013) 1.13
Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun (2013) 1.12
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med (2012) 1.12
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice. J Histochem Cytochem (2007) 1.10
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn (2004) 1.08
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol (2011) 1.07
Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem (2003) 1.07
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07
Roles for CCN2 in normal physiological processes. Cell Mol Life Sci (2011) 1.06
Expression of ADAMTS1 during murine development. Mech Dev (2002) 1.06
The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials (2009) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. J Histochem Cytochem (2009) 1.04
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development (2008) 1.04
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun (2007) 1.03
Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res (2011) 1.02
Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. Am J Pathol (2010) 1.02
Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet (2012) 1.02
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood (2011) 1.01
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int J Biochem Cell Biol (2008) 1.01
Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling. J Biol Chem (2005) 0.98