| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A role for phosphoinositide 3-kinase in bacterial invasion.
|
Science
|
1996
|
2.46
|
|
2
|
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway.
|
Hum Mol Genet
|
2000
|
1.92
|
|
3
|
Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.
|
Mol Biol Cell
|
2000
|
1.86
|
|
4
|
Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition.
|
Biochem Pharmacol
|
1997
|
1.64
|
|
5
|
Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis.
|
Leukemia
|
2006
|
1.58
|
|
6
|
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.
|
J Cell Biol
|
1995
|
1.57
|
|
7
|
A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.
|
J Biol Chem
|
2000
|
1.56
|
|
8
|
The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase.
|
J Biol Chem
|
1999
|
1.56
|
|
9
|
Interaction between the epidermal growth factor receptor and phosphoinositide kinases.
|
J Biol Chem
|
1991
|
1.40
|
|
10
|
A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase.
|
Blood
|
1999
|
1.40
|
|
11
|
The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia.
|
Leukemia
|
2009
|
1.38
|
|
12
|
A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia.
|
Oncogene
|
2006
|
1.37
|
|
13
|
Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.
|
J Biol Chem
|
2001
|
1.19
|
|
14
|
The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling.
|
Mol Microbiol
|
1999
|
1.18
|
|
15
|
Epidermal growth factor induces rapid and transient association of phospholipase C-gamma 1 with EGF-receptor and filamentous actin at membrane ruffles of A431 cells.
|
J Cell Sci
|
1995
|
1.17
|
|
16
|
Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation.
|
J Biol Chem
|
1998
|
1.15
|
|
17
|
Flavonoids and the inhibition of PKC and PI 3-kinase.
|
Gen Pharmacol
|
1999
|
1.12
|
|
18
|
Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets.
|
J Biol Chem
|
1998
|
1.10
|
|
19
|
Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome.
|
J Thromb Haemost
|
2011
|
1.08
|
|
20
|
Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow.
|
J Thromb Haemost
|
2010
|
1.06
|
|
21
|
A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets.
|
Biochem J
|
1999
|
1.05
|
|
22
|
An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.
|
J Biol Chem
|
1999
|
1.05
|
|
23
|
Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation.
|
Biochemistry
|
2001
|
1.05
|
|
24
|
Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.
|
Oncogene
|
2007
|
1.04
|
|
25
|
The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.
|
J Biol Chem
|
2001
|
1.03
|
|
26
|
Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets.
|
FEBS Lett
|
2001
|
1.02
|
|
27
|
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
|
J Biol Chem
|
1997
|
1.00
|
|
28
|
A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.
|
J Thromb Haemost
|
2005
|
0.99
|
|
29
|
Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase-dependent pathway.
|
Blood
|
2000
|
0.94
|
|
30
|
The invasion protein InIB from Listeria monocytogenes activates PLC-gamma1 downstream from PI 3-kinase.
|
Cell Microbiol
|
2000
|
0.93
|
|
31
|
Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets.
|
Biochem J
|
1993
|
0.90
|
|
32
|
The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin.
|
Biochem Biophys Res Commun
|
2001
|
0.88
|
|
33
|
Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.
|
Biochem Biophys Res Commun
|
2008
|
0.88
|
|
34
|
pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of alphaIIbbeta3 integrin in human platelets.
|
Biochem J
|
2000
|
0.87
|
|
35
|
Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells.
|
Leukemia
|
2011
|
0.87
|
|
36
|
FcgammaRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation.
|
Blood
|
2000
|
0.86
|
|
37
|
The phosphoinositide 3-kinase/Akt pathway is essential for the retinoic acid-induced differentiation of F9 cells.
|
Oncogene
|
2006
|
0.86
|
|
38
|
Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase.
|
J Biol Chem
|
1998
|
0.85
|
|
39
|
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.
|
Oncogene
|
2009
|
0.85
|
|
40
|
Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells.
|
Int J Oncol
|
2001
|
0.84
|
|
41
|
A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.
|
Cell Death Differ
|
2008
|
0.84
|
|
42
|
Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PAR1 activating peptide.
|
Thromb Haemost
|
2001
|
0.84
|
|
43
|
Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.
|
Blood Cancer J
|
2011
|
0.84
|
|
44
|
Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor.
|
J Thromb Haemost
|
2004
|
0.83
|
|
45
|
A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets.
|
J Thromb Haemost
|
2013
|
0.83
|
|
46
|
G-protein-stimulated phospholipase D activity is inhibited by lethal toxin from Clostridium sordellii in HL-60 cells.
|
J Biol Chem
|
1999
|
0.83
|
|
47
|
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.
|
FEBS Lett
|
1999
|
0.82
|
|
48
|
Alterations of the phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-independent Spi-1/PU.1 transgenic proerythroblasts.
|
Blood
|
2001
|
0.81
|
|
49
|
Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets.
|
FEBS Lett
|
1999
|
0.81
|
|
50
|
The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies.
|
J Thromb Haemost
|
2011
|
0.81
|
|
51
|
Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors.
|
Oncogene
|
2011
|
0.81
|
|
52
|
Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate.
|
J Biol Chem
|
1997
|
0.81
|
|
53
|
Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin.
|
Cell Mol Life Sci
|
2003
|
0.80
|
|
54
|
Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding.
|
J Biol Chem
|
1999
|
0.80
|
|
55
|
Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets.
|
Biochem Biophys Res Commun
|
1997
|
0.80
|
|
56
|
alphaIIb beta 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3',4'-biphosphate accumulation.
|
FEBS Lett
|
1996
|
0.80
|
|
57
|
The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors.
|
Leukemia
|
2012
|
0.80
|
|
58
|
Characterization of phosphatidylinositol-4-phosphate 5-kinase activities from bovine brain membranes.
|
Biochim Biophys Acta
|
1993
|
0.79
|
|
59
|
Phosphoinositides are involved in control of the glucose-dependent growth resumption that follows the transition phase in Streptomyces lividans.
|
J Bacteriol
|
2006
|
0.78
|
|
60
|
Rapid and transient thrombin stimulation of phosphatidylinositol 4,5-bisphosphate synthesis but not of phosphatidylinositol 3,4-bisphosphate independent of phospholipase C activation in platelets.
|
FEBS Lett
|
1993
|
0.78
|
|
61
|
Understanding the controversy about hormonal replacement therapy: insights from estrogen effects on experimental and clinical atherosclerosis.
|
Arch Mal Coeur Vaiss
|
2007
|
0.77
|
|
62
|
The platelet cytoskeleton regulates the aggregation-dependent synthesis of phosphatidylinositol 3,4-bisphosphate induced by thrombin.
|
FEBS Lett
|
2000
|
0.76
|
|
63
|
Phosphoinositide 3-kinase inhibition reverses platelet aggregation triggered by the combination of the neutrophil proteinases elastase and cathepsin G without impairing alpha(IIb)beta(3) integrin activation.
|
FEBS Lett
|
2000
|
0.76
|
|
64
|
Rapid and transient translocation of PLC-gamma 1 to the cytoskeleton of thrombin-stimulated platelets. Evidence for a role of tyrosine kinases.
|
Cell Mol Biol (Noisy-le-grand)
|
1994
|
0.76
|
|
65
|
Targeted drug therapy: the platelet side.
|
Platelets
|
2011
|
0.75
|
|
66
|
Inositol lipid metabolism, the cytoskeleton, glycoprotein IIb IIIa and platelets.
|
Adv Exp Med Biol
|
1993
|
0.75
|
|
67
|
Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3.
|
J Thromb Haemost
|
2003
|
0.75
|
|
68
|
Assessment of platelet response to clopidogrel through measurement of ADP-induced Akt phosphorylation.
|
J Thromb Haemost
|
2009
|
0.75
|
|
69
|
Calpains are involved in phosphatidylinositol 3',4'-bisphosphate synthesis dependent on the alpha IIb beta 3 integrin engagement in thrombin-stimulated platelets.
|
FEBS Lett
|
1997
|
0.75
|