Published in Proc Natl Acad Sci U S A on January 02, 2001
The role of glycosphingolipid metabolism in the developing brain. J Lipid Res (2008) 1.37
Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. Exp Neurol (2005) 1.32
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron (2014) 1.19
Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. Am J Hum Genet (2013) 1.15
Nuclear sphingolipids: metabolism and signaling. J Lipid Res (2008) 1.05
Glycosphingolipid functions: insights from engineered mouse models. Philos Trans R Soc Lond B Biol Sci (2003) 1.03
Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction. J Physiol (2009) 1.01
Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis. Glycoconj J (2004) 0.97
Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J (2004) 0.89
Ganglioside biochemistry. ISRN Biochem (2012) 0.89
Nuclear sphingolipid metabolism. Annu Rev Physiol (2011) 0.89
Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res (2011) 0.88
Monosialotetrahexosy-1 ganglioside attenuates diabetes-enhanced brain damage after transient forebrain ischemia and suppresses phosphorylation of ERK1/2 in the rat brain. Brain Res (2010) 0.80
Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. Glycoconj J (2004) 0.78
Interorganellar membrane microdomains: dynamic platforms in the control of calcium signaling and apoptosis. Cells (2013) 0.78
Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase. Biochim Biophys Acta (2014) 0.77
Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Genes Brain Behav (2017) 0.75
A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim Biophys Acta (1957) 11.28
Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci U S A (1979) 8.41
CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES. J Neurochem (1963) 6.22
Gangliosides: structure, isolation, and analysis. Methods Enzymol (1982) 3.20
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc Natl Acad Sci U S A (1996) 2.10
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95
Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease. Brain Res (1976) 1.77
The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci (1987) 1.69
Ganglioside metabolism. Enzymology, Topology, and regulation. J Biol Chem (1993) 1.59
Structure of the major glucosamine-containing ganglioside of human tissues. J Biol Chem (1973) 1.25
Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line. J Immunol (1994) 1.03
Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells. Proc Natl Acad Sci U S A (1990) 1.03
Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes. J Cell Biol (1987) 1.01
Structural study on tetraglycosyl ceremide and gangliosides isolated from human red blood cells. J Biochem (1973) 0.98
The role(s) of gangliosides in neural differentiation and repair: a perspective. Brain Res Bull (1990) 0.95
Organization of ganglioside synthesis in the Golgi apparatus. Biochim Biophys Acta (1999) 0.95
The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci (1998) 0.95
Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells. J Biol Chem (1994) 0.89
Neuronal calcium sparks and intracellular calcium "noise". Proc Natl Acad Sci U S A (1999) 0.89
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells. J Neurosci (1994) 0.88
Stimulation of neurite outgrowth in neuroblastoma cells by neuraminidase: putative role of GM1 ganglioside in differentiation. J Neurochem (1991) 0.88
Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane. J Neurosci (1995) 0.86
Modulation of a Ca2+ signaling pathway by GM1 ganglioside in PC12 cells. J Biol Chem (1992) 0.85
Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides. J Biol Chem (1998) 0.84
Gangliosides as modulators of neuronal calcium. Prog Brain Res (1994) 0.83
Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells. J Neurosci Res (1999) 0.83
Glycosphingolipids of skeletal muscle: II. Modulation of Ca2(+)-flux in triad membranes by gangliosides. Carbohydr Res (1998) 0.82
Gangliosides in the nervous system during development and regeneration. Neurochem Pathol (1986) 0.82
Differences in transmitter release, morphology, and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration. Brain Res Dev Brain Res (1991) 0.82
Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase. FEBS Lett (1999) 0.81
Endogenous GM1 ganglioside of the plasma membrane promotes neuritogenesis by two mechanisms. Neurochem Res (2000) 0.80
Regulation of intracellular calcium in cerebellar granule neurons: effects of depolarization and of glutamatergic and cholinergic stimulation. J Neurochem (1991) 0.80
Trophic effect of cholera toxin B subunit in cultured cerebellar granule neurons: modulation of intracellular calcium by GM1 ganglioside. J Neurosci Res (1996) 0.79
GM1 ganglioside in the nuclear membrane modulates nuclear calcium homeostasis during neurite outgrowth. J Neurochem (1995) 0.79
Calcium regulation of neuronal differentiation: the role of calcium in GM1-mediated neuritogenesis. Brain Res Dev Brain Res (1990) 0.79
Gangliosides stimulate calcium flux in neuro-2A cells and require exogenous calcium for neuritogenesis. J Neurochem (1990) 0.79
Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth. J Cell Biol (1992) 0.79
AMPA receptor subunit mRNAs and intracellular [Ca(2+)] in cultured mouse and rat cerebellar granule cells. Int J Dev Neurosci (2000) 0.78
Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. Brain Res Dev Brain Res (1999) 0.78
Protection of neuro-2a cells against calcium ionophore cytotoxicity by gangliosides. J Neurosci Res (1992) 0.78
Gangliosides inhibit platelet-derived growth-factor-stimulated increases in intracellular calcium in Swiss 3T3 cells. Biochim Biophys Acta (1992) 0.77
Gangliosides raise the intracellular Ca2+ level in different cell types. Life Sci (1995) 0.76
Exogenous gangliosides modulate calcium fluxes in cultured neuronal cells. J Neurosci Res (1992) 0.76
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
Translocation (8;21) in oligoblastic leukemia: is this a true myelodysplastic syndrome? Leuk Res (1994) 3.66
Gangliosides: structure, isolation, and analysis. Methods Enzymol (1982) 3.20
Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol (2000) 2.74
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J Virol (1997) 2.67
Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea. Blood (1997) 2.55
Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Prog Neurobiol (1994) 2.36
Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc Natl Acad Sci U S A (1997) 2.34
A histone octamer-like structure within TFIID. Nature (1996) 2.21
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nat Biotechnol (1999) 2.09
17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J Neurophysiol (1999) 2.08
Association of nonspecific minor ST-T abnormalities with cardiovascular mortality: the Chicago Western Electric Study. JAMA (1999) 2.00
Gangliosides of human, bovine, and rabbit plasma. J Lipid Res (1972) 1.99
Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada. Am J Public Health (1999) 1.99
The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor. J Exp Med (1995) 1.95
Assessment methods for alcohol consumption, prevalence of high risk drinking and harm: a sensitivity analysis. Int J Epidemiol (1999) 1.84
Molecular and statistical approaches to the detection and correction of errors in genotype databases. Am J Hum Genet (1993) 1.84
Gangliosides of human myelin: sialosylgalactosylceramide (G7) as a major component. J Neurochem (1973) 1.84
Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene (2012) 1.80
GABAA receptors are differentially sensitive to zinc: dependence on subunit composition. Br J Pharmacol (1991) 1.80
Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J Exp Med (2001) 1.78
Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem (2001) 1.77
Chlorinated indium tin oxide electrodes with high work function for organic device compatibility. Science (2011) 1.76
Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron (1994) 1.59
Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen. J Clin Invest (1994) 1.53
The economic costs of alcohol, tobacco and illicit drugs in Canada, 1992. Addiction (1998) 1.53
beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. J Exp Med (1998) 1.49
Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis (2009) 1.46
Purpose in life, boredom, and volunteerism in a group of retirees. Psychol Rep (1995) 1.46
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors. Am J Transplant (2013) 1.44
Femtosecond spontaneous-emission studies of reaction centers from photosynthetic bacteria. Proc Natl Acad Sci U S A (1992) 1.42
A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease. Aliment Pharmacol Ther (2015) 1.41
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci (1998) 1.39
Precision refractive index measurements of air, N2, O2, Ar, and CO2 with a frequency comb. Appl Opt (2008) 1.38
Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins. FASEB J (2001) 1.35
Accuracy of nasal cannula pressure recordings for assessment of ventilation during sleep. Am J Respir Crit Care Med (2001) 1.33
Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res (1996) 1.31
Gas--liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species. J Lipid Res (1970) 1.31
Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocytosis in experimental meningitis in the rabbit. J Clin Invest (1994) 1.30
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. Clin Cancer Res (2001) 1.29
Chemoattractant-induced firm adhesion of leukocytes to vascular endothelium in vivo is critically dependent on initial leukocyte rolling. Acta Physiol Scand (1992) 1.29
Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration. J Biol Chem (2000) 1.24
Identification of cancer stem cell-like cells from human epithelial ovarian carcinoma cell line. Cell Mol Life Sci (2010) 1.21
Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppression. J Biol Chem (1998) 1.21
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. Br J Cancer (2009) 1.20
The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis. Br J Cancer (2013) 1.17
Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood (2000) 1.17
Overexpression of White Collar-1 (WC-1) activates circadian clock-associated genes, but is not sufficient to induce most light-regulated gene expression in Neurospora crassa. Mol Microbiol (2002) 1.16
Gangliosides of peripheral nerve myelin. J Neurochem (1976) 1.15
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene (2010) 1.13
Structure of tropomyosin at 9 angstroms resolution. J Mol Biol (1992) 1.13
Fetal sensitivity to properties of maternal speech and language. Infant Behav Dev (2008) 1.12
The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J Leukoc Biol (1996) 1.11
Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli. Drug Discov Today Dis Models (2008) 1.10
Placement of covered stents for the treatment of direct carotid cavernous fistulas. AJNR Am J Neuroradiol (2009) 1.09
The natural silk spinning process. A nucleation-dependent aggregation mechanism? Eur J Biochem (2001) 1.08
Induction of axon-like and dendrite-like processes in neuroblastoma cells. J Neurocytol (1998) 1.07
Histone-like transcription factors in eukaryotes. Curr Opin Struct Biol (1997) 1.07
A randomized, controlled crossover trial of two oral appliances for sleep apnea treatment. Am J Respir Crit Care Med (2000) 1.05
Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex. J Biol Chem (2000) 1.02
Ganglioside structures and distribution: are they localized at the nerve ending? J Supramol Struct (1978) 1.02
Axonal transport of gangliosides in the goldfish optic nerve. Science (1972) 1.02
Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D. J Biol Chem (2000) 1.01
Quantum dot microdrop laser. Nano Lett (2008) 1.01
Sub-region specific contribution of the ventral hippocampus to drug context-induced reinstatement of cocaine-seeking behavior in rats. Neuroscience (2010) 1.01
CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins. J Biol Chem (1998) 1.01
Nature of the Sendai virus receptor: glycoprotein versus ganglioside. J Virol (1980) 1.01
Molecular evidence for chlamydial infections in the eyes of sheep. Vet Microbiol (2008) 1.01
miR-375 is upregulated in acquired paclitaxel resistance in cervical cancer. Br J Cancer (2013) 1.00
Celecoxib can prevent capecitabine-related hand-foot syndrome in stage II and III colorectal cancer patients: result of a single-center, prospective randomized phase III trial. Ann Oncol (2011) 1.00
Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Biochem J (2000) 0.99
Axonal transport of phospholipid in goldfish optic system. Exp Neurol (1975) 0.99
Isolation of two glycolipid transfer proteins from bovine brain: reactivity toward gangliosides and neutral glycosphingolipids. Biochemistry (1987) 0.98
Different doses of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: the role of nitric oxide. J Immunol (1999) 0.98
Precision measurement of the refractive index of air with frequency combs. Opt Lett (2005) 0.98
Quantum dot selective area intermixing for broadband light sources. Opt Express (2012) 0.98
Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells. Neoplasma (2015) 0.97
Hepatitis B and breastfeeding in Hangzhou, Zhejiang Province, People's Republic of China. Breastfeed Med (2010) 0.96
Adjuvant chemotherapy versus surgery alone for esophageal squamous cell carcinoma: a meta-analysis of randomized controlled trials and nonrandomized studies. Dis Esophagus (2013) 0.96
Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. Exp Oncol (2008) 0.95
The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci (1998) 0.95
Study on CXCR4/SDF-1alpha axis in lymph node metastasis of cervical squamous cell carcinoma. Int J Gynecol Cancer (2007) 0.95
Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China. Int J Gynecol Cancer (2007) 0.95
Molecular characterization of a rat alpha 2B-adrenergic receptor. Proc Natl Acad Sci U S A (1990) 0.94
Promoter and regulatory regions of the rat luteinizing hormone receptor gene. J Biol Chem (1993) 0.94
Meta-analysis of randomized clinical trials on safety and efficacy of biliary drainage before surgery for obstructive jaundice. Br J Surg (2013) 0.94
Outcomes of conservative surgery in early epithelial ovarian carcinoma. Eur J Gynaecol Oncol (2012) 0.94
NMDA receptor-dependent LTD in different subfields of hippocampus in vivo and in vitro. Hippocampus (1996) 0.94
Air pollution-type fluorosis in the region of Pingxiang, Jiangxi, Peoples' Republic of China. Arch Environ Health (1993) 0.94
Detection of mycobacteria and chlamydiae in granulomatous inflammation of reptiles: a retrospective study. Vet Pathol (2004) 0.93
Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model. Cancer Gene Ther (2006) 0.92
Development and evaluation of a one-step loop-mediated isothermal amplification for detection of spring viraemia of carp virus. J Appl Microbiol (2008) 0.92
Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol (2007) 0.92
Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12. Cancer Gene Ther (2000) 0.92
Diagnostic investigation into the role of Chlamydiae in cases of increased rates of return to oestrus in pigs. Vet Rec (2004) 0.91
Ganglioside abnormalities in multiple sclerosis. J Neurochem (1974) 0.91
Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level. Hum Gene Ther (2000) 0.90
Prevalence of diabetes mellitus in China. Exp Clin Endocrinol Diabetes (2007) 0.90
Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival. Oncogene (2009) 0.90