Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis.

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Published in Glycoconj J on January 01, 2004

Authors

Erhard Bieberich1

Author Affiliations

1: Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB-2803, Augusta, GA 30912, USA. ebieberich@mail.mcg.edu

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Development regulation of ganglioside metabolism. Prog Brain Res (1994) 1.04

Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides. J Biol Chem (2001) 1.03

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The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. Cell Death Differ (1998) 0.94

Regulation of cyclin-dependent kinase 2 activity by ceramide. Exp Cell Res (2000) 0.94

Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2. Proc Natl Acad Sci U S A (2002) 0.93

Cancer dormancy: role of cyclin-dependent kinase inhibitors in induction of cell cycle arrest mediated via membrane IgM. Cancer Res (1998) 0.92