Published in FASEB J on February 01, 2001
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet (2006) 2.43
The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet (2007) 2.25
Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss. J Gerontol A Biol Sci Med Sci (2007) 1.69
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet (2008) 1.62
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One (2010) 1.58
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res (2001) 1.48
The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol (2007) 1.41
Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.40
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol (2013) 1.38
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. J Transl Med (2016) 1.38
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta (2009) 1.31
Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan. Exp Gerontol (2006) 1.29
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
Carotenoids as protection against sarcopenia in older adults. Arch Biochem Biophys (2006) 1.27
Skeletal muscle mitochondria and aging: a review. J Aging Res (2012) 1.27
Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med (2011) 1.24
Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J (2010) 1.23
Sarcopenia accelerates at advanced ages in Fisher 344xBrown Norway rats. J Gerontol A Biol Sci Med Sci (2008) 1.19
Quantification of random mutations in the mitochondrial genome. Methods (2008) 1.14
The ageing mitochondrial genome. Nucleic Acids Res (2007) 1.11
Skeletal muscle aging and the mitochondrion. Trends Endocrinol Metab (2013) 1.10
Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle. Exp Gerontol (2010) 1.08
Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass. J Cachexia Sarcopenia Muscle (2012) 1.06
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem (2013) 1.04
Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels. J Physiol (2011) 1.03
Reconsidering the Role of Mitochondria in Aging. J Gerontol A Biol Sci Med Sci (2015) 0.98
Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal (2012) 0.98
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell (2011) 0.97
Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J (2013) 0.96
Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies. Mech Ageing Dev (2011) 0.95
Mitochondrial dysfunction in aging: Much progress but many unresolved questions. Biochim Biophys Acta (2015) 0.94
Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice. Mitochondrion (2013) 0.94
Mitochondrial involvement and impact in aging skeletal muscle. Front Aging Neurosci (2014) 0.93
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One (2013) 0.92
Relationship between human aging muscle and oxidative system pathway. Oxid Med Cell Longev (2012) 0.92
Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'. Trends Genet (2010) 0.90
Mitochondrial DNA: impacting central and peripheral nervous systems. Neuron (2014) 0.90
Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silico. PLoS Comput Biol (2009) 0.90
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice. Skelet Muscle (2017) 0.89
Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun (2015) 0.89
Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization. Cell Metab (2015) 0.89
Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol (2015) 0.88
Exercise attenuates the major hallmarks of aging. Rejuvenation Res (2015) 0.87
Successful aging: Advancing the science of physical independence in older adults. Ageing Res Rev (2015) 0.86
Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function. J Appl Physiol (1985) (2014) 0.86
Huntington's disease and mitochondrial DNA deletions: event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?! Cell Mol Neurobiol (2007) 0.86
Programmed cell death in aging. Ageing Res Rev (2015) 0.86
Mitochondrial biogenesis drives a vicious cycle of metabolic insufficiency and mitochondrial DNA deletion mutation accumulation in aged rat skeletal muscle fibers. PLoS One (2013) 0.85
Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell (2015) 0.83
Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice. Exp Gerontol (2014) 0.83
Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity? Philos Trans R Soc Lond B Biol Sci (2014) 0.82
Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations. PLoS Comput Biol (2015) 0.82
Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle. PLoS One (2013) 0.81
Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Exp Gerontol (2011) 0.81
Mitochondrial dysfunction in cardiac aging. Biochim Biophys Acta (2015) 0.80
The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer. Mech Ageing Dev (2006) 0.80
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance. PLoS One (2013) 0.79
Natural variation in Caenorhabditis briggsae mitochondrial form and function suggests a novel model of organelle dynamics. Mitochondrion (2012) 0.78
Modeling the aging heart: from local respiratory defects to global rhythm disturbances. Cell Metab (2015) 0.78
Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat. Am J Physiol Heart Circ Physiol (2013) 0.78
Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training. J Appl Physiol (1985) (2014) 0.77
Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice. BMC Complement Altern Med (2014) 0.77
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med (2015) 0.76
Failed reinnervation in aging skeletal muscle. Skelet Muscle (2016) 0.76
Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age. Aging Cell (2016) 0.75
Mitochondrial quality control in insulin resistance and diabetes. Curr Opin Genet Dev (2016) 0.75
Single Cell Multiplex Protein Measurements through Rare Earth Element Immunolabeling, Laser Capture Microdissection and Inductively Coupled Mass Spectrometry. J Cytol Histol (2014) 0.75
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age. PLoS One (2014) 0.75
Cytochrome c oxidase deficiency in human posterior cricoarytenoid muscle. J Voice (2010) 0.75
Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy. Aging Cell (2017) 0.75
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature (1999) 7.31
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev (1995) 6.03
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity (1997) 5.23
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene (2001) 3.97
Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med (2000) 3.14
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A (1998) 3.04
Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol Cell Biol (1999) 2.77
Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science (1992) 2.61
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem (1999) 2.43
Reappraisal of the role of axillary lymph node dissection in the conservative treatment of breast cancer. J Clin Oncol (1997) 2.35
Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci (2001) 2.31
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol (1999) 2.11
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes Dev (1996) 2.07
The host range of chronic wasting disease is altered on passage in ferrets. Virology (1998) 1.95
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67
Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy. J Virol (2000) 1.66
A naturally occurring non-coding fusion transcript derived from scorpion venom gland: implication for the regulation of scorpion toxin gene expression. FEBS Lett (2001) 1.58
Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J Biol Chem (1993) 1.54
CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J (1997) 1.54
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1994) 1.53
A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species. J Infect Dis (1999) 1.51
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res (2001) 1.48
Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. Antimicrob Agents Chemother (2000) 1.47
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. Science (1992) 1.44
NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J Biol Chem (1995) 1.42
Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. Br J Cancer (2002) 1.32
Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. Microb Drug Resist (1999) 1.30
First observation of the Greisen-Zatsepin-Kuzmin suppression. Phys Rev Lett (2008) 1.29
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Ligand-specific opening of a gated-porin channel in the outer membrane of living bacteria. Science (1997) 1.25
Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy. Cancer Res (1999) 1.24
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Interaction of von Willebrand factor domain A1 with platelet glycoprotein Ibalpha-(1-289). Slow intrinsic binding kinetics mediate rapid platelet adhesion. J Biol Chem (2000) 1.23
Characterization of HetR protein turnover in Anabaena sp. PCC 7120. Arch Microbiol (1998) 1.22
Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia (2001) 1.21
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
The effects of a sensory extinction procedure on stereotypic sounds of two autistic children. J Autism Dev Disord (1984) 1.19
Binding of ferric enterobactin by the Escherichia coli periplasmic protein FepB. J Bacteriol (2000) 1.18
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Local recurrence in the conservatively treated breast cancer patient: a correlation with age and family history. Cancer J Sci Am (1998) 1.15
Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. J Neurosci (1993) 1.13
Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells. J Biol Chem (2001) 1.13
Pathogenesis of Acanthamoeba keratitis: carbohydrate-mediated host-parasite interactions. Infect Immun (1997) 1.12
Tumor-specific gene expression using the survivin promoter is further increased by hypoxia. Gene Ther (2004) 1.11
Double mutagenesis of a positive charge cluster in the ligand-binding site of the ferric enterobactin receptor, FepA. Proc Natl Acad Sci U S A (1997) 1.11
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
Proteases as markers for differentiation of pathogenic and nonpathogenic species of Acanthamoeba. J Clin Microbiol (2000) 1.07
Extra small virus-like particles (XSV) and nodavirus associated with whitish muscle disease in the giant freshwater prawn, Macrobrachium rosenbergii. J Fish Dis (2003) 1.06
Sequence homologies in the protamine gene family of rainbow trout. Nucleic Acids Res (1983) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Transmissible mink encephalopathy species barrier effect between ferret and mink: PrP gene and protein analysis. J Gen Virol (1994) 1.04
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Exchangeability of N termini in the ligand-gated porins of Escherichia coli. J Biol Chem (2001) 1.02
Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis. J Biol Chem (1998) 1.02
Differential effects mediated by GABAA receptors in thalamic nuclei in lh/lh model of absence seizures. Epilepsy Res (1997) 1.01
Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J Biol Chem (1992) 1.01
Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases. Diabetologia (2002) 1.01
Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy. Kidney Int Suppl (1999) 1.00
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma. Histopathology (2008) 0.99
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. J Med Chem (2001) 0.97
A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery. Gene Ther (2009) 0.97
Evidence for type III restriction and modification systems in Mycoplasma pulmonis. J Bacteriol (2007) 0.96
Indoor air pollution and pulmonary function in children. Biomed Environ Sci (1992) 0.96
Nucleotide sequence of a protamine component CII gene of Salmo gairdnerii. Nucleic Acids Res (1982) 0.95
Molecular aptamer for real-time oncoprotein platelet-derived growth factor monitoring by fluorescence anisotropy. Anal Chem (2001) 0.95
Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes. Circ Res (2000) 0.95
αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Curr Mol Med (2012) 0.95
Persistence and expression of Microplitis demolitor polydnavirus in Pseudoplusia includens. J Gen Virol (1992) 0.94
Dependence of anticancer activity of camptothecins on maintaining their lactone function. Ann N Y Acad Sci (2000) 0.94
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem (2001) 0.92
Mining drug-disease relationships as a complement to medical genetics-based drug repositioning: Where a recommendation system meets genome-wide association studies. Clin Pharmacol Ther (2015) 0.92
Biphasic binding kinetics between FepA and its ligands. J Biol Chem (1997) 0.91
MAST3: a novel IBD risk factor that modulates TLR4 signaling. Genes Immun (2008) 0.90
Protective effects of baicalin on ligature-induced periodontitis in rats. J Periodontal Res (2008) 0.90
Lipofection indirectly increases expression of endogenous major histocompatibility complex class I molecules on tumor cells. Cancer Gene Ther (1999) 0.89
Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies. Diabetes (1997) 0.89
Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin II infusion. J Hypertens (2001) 0.89
Responses of bone-forming cells on pre-immersed Zr-based bulk metallic glasses: Effects of composition and roughness. Acta Biomater (2010) 0.88
In situ detection of the Clostridium botulinum type C1 toxin gene in wetland sediments with a nested PCR assay. Appl Environ Microbiol (1999) 0.87
Prevention of murine influenza A virus pneumonitis by surfactant nano-emulsions. Antivir Chem Chemother (2000) 0.87
Toothbrush efficacy for plaque removal. Int J Dent Hyg (2014) 0.87
Renoprotective effects of vasopeptidase inhibition in an experimental model of diabetic nephropathy. Diabetologia (2003) 0.86
Target values and method evaluation in proficiency testing programs. Clin Chem (2001) 0.86
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. J Neurosci (1991) 0.85
Antimicrobial peptides expression by ocular surface cells in response to Acanthamoeba castellanii: an in vitro study. Br J Ophthalmol (2010) 0.85
The role of amino-terminal disulfide bonds in the structure and assembly of human fibrinogen. Biochem Biophys Res Commun (1993) 0.85
Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Ann N Y Acad Sci (1998) 0.85
Combination of valproic acid and ATRA restores RARβ2 expression and induces differentiation in cervical cancer through the PI3K/Akt pathway. Curr Mol Med (2012) 0.85
Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res (1998) 0.85
Vascular hypertrophy and albumin permeability in a rat model combining hypertension and diabetes mellitus. Effects of calcium antagonism, angiotensin converting enzyme inhibition, and angiotensin II-AT1-receptor blockade. Am J Hypertens (1996) 0.84
The beta 1 sodium channel subunit modifies the interactions of neurotoxins and local anesthetics with the rat brain IIA alpha sodium channel in isolated membranes but not in intact cells. Neuropharmacology (1996) 0.84
Regulation of cell-type-specific transcription and differentiation of the pituitary. Bioessays (1990) 0.84
No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients. Neoplasma (2008) 0.84