Published in J Gerontol on November 01, 1993
Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94
Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res (1995) 1.84
Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss. J Gerontol A Biol Sci Med Sci (2007) 1.69
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57
Mitochondrial DNA repair in aging and disease. Mech Ageing Dev (2008) 1.43
The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol (2007) 1.41
Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res (1995) 1.21
Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res (1997) 1.20
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLoS Comput Biol (2012) 0.97
Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev (2010) 0.93
Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. PLoS One (2013) 0.89
Mitochondria, oxidative DNA damage, and aging. J Am Aging Assoc (2000) 0.85
Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell (2015) 0.83
A morphometric study on human muscle mitochondria in aging. J Am Aging Assoc (2002) 0.78
Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women. J Gerontol A Biol Sci Med Sci (2015) 0.77
Contributions of Nonhuman Primates to Research on Aging. Vet Pathol (2016) 0.76
Tissue-specific implications of mitochondrial alterations in aging. Front Biosci (Elite Ed) (2013) 0.76
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
A randomized trial of nonoperative treatment for perforated peptic ulcer. N Engl J Med (1989) 2.63
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J (2001) 2.05
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
The host range of chronic wasting disease is altered on passage in ferrets. Virology (1998) 1.95
Purification, identification, and characterization of an osmotic response element binding protein. Biochem Biophys Res Commun (2000) 1.84
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem (1998) 1.82
Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J (1999) 1.76
Osteoconduction at porous hydroxyapatite with various pore configurations. Biomaterials (2000) 1.71
Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy. J Virol (2000) 1.66
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Gamma knife for glioma: selection factors and survival. Int J Radiat Oncol Biol Phys (1996) 1.56
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res (2001) 1.48
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Unilateral globus pallidus internus stimulation improves delayed onset post-traumatic cervical dystonia with an ipsilateral focal basal ganglia lesion. J Neurol Neurosurg Psychiatry (2002) 1.47
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. J Biol Chem (1997) 1.47
Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci U S A (1995) 1.43
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res (1999) 1.36
Construction and phenotypic evaluation of a Vibrio vulnificus vvpE mutant for elastolytic protease. Infect Immun (2000) 1.34
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
An increase in Helicobacter pylori strains resistant to metronidazole: a five-year study. Helicobacter (1996) 1.27
A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia (2008) 1.24
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr (1992) 1.21
Elective stenting for symptomatic middle cerebral artery stenosis presenting as transient ischaemic deficits or stroke attacks: short term arteriographical and clinical outcome. J Neurol Neurosurg Psychiatry (2004) 1.21
An analysis of the natural history of cavernous malformations. Surg Neurol (1997) 1.20
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
The effects of a sensory extinction procedure on stereotypic sounds of two autistic children. J Autism Dev Disord (1984) 1.19
Choledocholithiasis: comparison of MR cholangiography and endoscopic retrograde cholangiography. Radiology (1996) 1.19
Direct identification of Vibrio vulnificus in clinical specimens by nested PCR. J Clin Microbiol (1998) 1.18
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Treatment of spontaneous arterial dissections with stent placement for preservation of the parent artery. Acta Neurochir (Wien) (2005) 1.17
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst (1999) 1.14
Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Mol Cell Biol (2000) 1.14
Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys (1996) 1.14
Vibrio vulnificus has the transmembrane transcription activator ToxRS stimulating the expression of the hemolysin gene vvhA. J Bacteriol (2000) 1.12
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr (1987) 1.06
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Sequence homologies in the protamine gene family of rainbow trout. Nucleic Acids Res (1983) 1.05
An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes (1995) 1.04
Transmissible mink encephalopathy species barrier effect between ferret and mink: PrP gene and protein analysis. J Gen Virol (1994) 1.04
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
Vibrio vulnificus hemolysin dilates rat thoracic aorta by activating guanylate cyclase. Life Sci (1996) 1.02
The expression and regulation of hsdK genes after conjugative transfer. Mol Gen Genet (1993) 1.01
Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A (1982) 1.00
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Comparison of Zielke ventral derotation system and Cotrel-Dubousset instrumentation in the treatment of idiopathic lumbar and thoracolumbar scoliosis. Spine (Phila Pa 1976) (1994) 0.99
Complications after gamma knife radiosurgery for benign meningiomas. J Neurol Neurosurg Psychiatry (2003) 0.98
Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland. Biochem J (1995) 0.98
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Percutaneous cervical radiofrequency cordotomy for intractable pain. Yonsei Med J (1975) 0.96
Overexpression of aldose reductase in liver cancers may contribute to drug resistance. Anticancer Drugs (2001) 0.96
Concerns about rodent models for aging research. J Gerontol (1991) 0.96
Nucleotide sequence of a protamine component CII gene of Salmo gairdnerii. Nucleic Acids Res (1982) 0.95
Caloric restriction, aging, and antioxidant enzymes. Mutat Res (1993) 0.95
Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med (1999) 0.94
Persistence and expression of Microplitis demolitor polydnavirus in Pseudoplusia includens. J Gen Virol (1992) 0.94
Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice. Cancer Res (1994) 0.93
Nurses' attitudes toward substance misusers. II. Experiments and studies comparing nurses to other groups. Subst Use Misuse (2000) 0.93
Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem (1995) 0.93
Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy. Epilepsy Res (2002) 0.92
The prevalence of dysequilibrium and related disorders in older persons. Ear Nose Throat J (1989) 0.92
Increase in the level of m-calpain correlates with the elevated cleavage of filamin during myogenic differentiation of embryonic muscle cells. Biochim Biophys Acta (1993) 0.92
Changes in the expression of junctional and nonjunctional complex component genes when inter-sertoli tight junctions are formed in vitro. J Androl (2000) 0.92