Published in Nucleic Acids Res on November 01, 2001
Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci (2008) 4.32
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet (2006) 2.43
The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet (2007) 2.25
Cellular senescence and tumor suppressor gene p16. Int J Cancer (2011) 2.14
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss. J Gerontol A Biol Sci Med Sci (2007) 1.69
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet (2008) 1.62
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One (2010) 1.58
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51
The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol (2007) 1.41
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta (2009) 1.31
Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle. Exp Gerontol (2010) 1.08
Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J Hepatol (2010) 1.07
Evolution of the mitochondrial fusion-fission cycle and its role in aging. Proc Natl Acad Sci U S A (2011) 1.06
The evolution and role of mitochondrial fusion and fission in aging and disease. Commun Integr Biol (2011) 0.94
Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles. Invest Ophthalmol Vis Sci (2010) 0.88
Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging. Proc Natl Acad Sci U S A (2014) 0.87
Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function. J Appl Physiol (1985) (2014) 0.86
Fiber type-specific differences in glucose uptake by single fibers from skeletal muscles of 9- and 25-month-old rats. J Gerontol A Biol Sci Med Sci (2012) 0.85
Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities. Aging Cell (2015) 0.83
Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity? Philos Trans R Soc Lond B Biol Sci (2014) 0.82
Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Exp Gerontol (2011) 0.81
Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence? PLoS One (2012) 0.81
Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis. Nucleic Acids Res (2016) 0.81
Natural selection of mitochondria during somatic lifetime promotes healthy aging. Front Neuroenergetics (2013) 0.79
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. J Aging Res (2012) 0.78
Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training. J Appl Physiol (1985) (2014) 0.77
Mitochondrial DNA deletion and sarcopenia. Genet Med (2009) 0.77
Selections that isolate recombinant mitochondrial genomes in animals. Elife (2015) 0.77
Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice. BMC Complement Altern Med (2014) 0.77
Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging. Nucleic Acids Res (2009) 0.77
Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions. Sci Rep (2016) 0.77
Cytochrome c oxidase deficiency in human posterior cricoarytenoid muscle. J Voice (2010) 0.75
Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age. Aging Cell (2016) 0.75
Mitochondrial quality control in insulin resistance and diabetes. Curr Opin Genet Dev (2016) 0.75
Myopathology of Adult and Paediatric Mitochondrial Diseases. J Clin Med (2017) 0.75
Accurate and comprehensive analysis of single nucleotide variants and large deletions of the human mitochondrial genome in DNA and single cells. Eur J Hum Genet (2017) 0.75
Mitochondrial diseases in man and mouse. Science (1999) 11.67
Replication of animal mitochondrial DNA. Cell (1982) 7.79
Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). J Cell Biol (1968) 4.22
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A (1974) 3.58
Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res (1990) 3.13
Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci U S A (1991) 3.00
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A (1992) 2.83
Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci U S A (1989) 2.63
Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nat Genet (1992) 2.15
Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol (1998) 2.08
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J (2001) 2.05
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res (1992) 1.97
Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett (1988) 1.79
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res (1999) 1.64
The mitochondrial theory of aging: do damaged mitochondria accumulate by delayed degradation? Exp Gerontol (1999) 1.56
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol (1989) 1.54
Mitochondrial DNA repair pathways. Mutat Res (1999) 1.53
A proposed refinement of the mitochondrial free radical theory of aging. Bioessays (1997) 1.48
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci (1990) 1.46
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch A Pathol Anat Histopathol (1993) 1.34
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett (1992) 1.26
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues. Hum Mol Genet (2001) 1.11
Mitochondria in organismal aging and degeneration. Biochim Biophys Acta (1999) 1.05
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs. J Biol Chem (1999) 0.93
Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR. Methods Enzymol (1996) 0.92
Quantitative allele-specific PCR: demonstration of age-associated accumulation in human tissues of the A-->G mutation at nucleotide 3243 in mitochondrial DNA. Hum Mutat (1997) 0.91
Study of mitochondrial DNA depletion in muscle by single-fiber polymerase chain reaction. Muscle Nerve (1998) 0.83
Single-fiber PCR in MELAS(3243) patients: correlations between intratissue distribution and phenotypic expression of the mtDNA(A3243G) genotype. Am J Med Genet (2000) 0.82
Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot. Mutat Res (1996) 0.82
Mitochondrial DNA rearrangements, including partial duplications, occur in young and old rat tissues. Mutat Res (1998) 0.81
Single muscle fiber analysis of myoclonus epilepsy with ragged-red fibers. Muscle Nerve (1998) 0.80
Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing. Mutat Res (1992) 0.78
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J (2001) 2.05
The host range of chronic wasting disease is altered on passage in ferrets. Virology (1998) 1.95
Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy. J Virol (2000) 1.66
Molecular and cellular biology of interleukin-6 and its receptor. Front Biosci (1996) 1.30
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
The effects of a sensory extinction procedure on stereotypic sounds of two autistic children. J Autism Dev Disord (1984) 1.19
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
Sequence homologies in the protamine gene family of rainbow trout. Nucleic Acids Res (1983) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Transmissible mink encephalopathy species barrier effect between ferret and mink: PrP gene and protein analysis. J Gen Virol (1994) 1.04
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Nucleotide sequence of a protamine component CII gene of Salmo gairdnerii. Nucleic Acids Res (1982) 0.95
Persistence and expression of Microplitis demolitor polydnavirus in Pseudoplusia includens. J Gen Virol (1992) 0.94
In situ detection of the Clostridium botulinum type C1 toxin gene in wetland sediments with a nested PCR assay. Appl Environ Microbiol (1999) 0.87
Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice. Ann N Y Acad Sci (1998) 0.85
Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res (1998) 0.85
Different lots of bovine serum albumin inhibit or stimulate in vitro development of hamster embryos. In Vitro Cell Dev Biol (1992) 0.84
Ecdysteroid induction of embryonic morphogenesis in a parasitic wasp. Dev Biol (1993) 0.83
Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys. Mech Ageing Dev (1994) 0.82
Heat stress induced enhancement of heat shock protein gene activity in the honey bee (Apis mellifera). Experientia (1990) 0.81
Tandem repeats of a specific alternating purine-pyrimidine DNA sequence adjacent to protamine genes in the rainbow trout that can exist in the Z form. Biochemistry (1985) 0.79
Effect of antibiotics on development in vitro of hamster pronucleate ova. Theriogenology (2000) 0.77
Golden hamster embryonic genome activation occurs at the two-cell stage: correlation with major developmental changes. Mol Reprod Dev (1992) 0.76
Parental presence not necessary during induction of anesthesia. Anesthesiology (1996) 0.75
Qualitative comparison of protein production at different stages of hamster preimplantation embryo development. Cell Differ Dev (1990) 0.75
Nucleotide sequence of a middle repetitive DNA from honey bees. Gene (1991) 0.75