Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

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Published in J Exp Med on February 05, 2001

Authors

A D Kelleher1, C Long, E C Holmes, R L Allen, J Wilson, C Conlon, C Workman, S Shaunak, K Olson, P Goulder, C Brander, G Ogg, J S Sullivan, W Dyer, I Jones, A J McMichael, S Rowland-Jones, R E Phillips

Author Affiliations

1: Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom. kelleher@worf.molbiol.ox.ac.uk

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Bias due to misclassification in the estimation of relative risk. Am J Epidemiol (1977) 7.28

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Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol (1997) 3.24

European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis (2009) 3.22

Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science (2000) 3.20

Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J Virol (2000) 3.18

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A human lymphocyte-associated antigen involved in cell-mediated lympholysis. Eur J Immunol (1983) 3.08

Defying death after DNA damage. Nature (2000) 3.03

Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection. AIDS Res Hum Retroviruses (1996) 3.01

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat Med (1996) 2.96

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Infection of the surgical site after arthroplasty of the hip. J Bone Joint Surg Br (2005) 2.94

Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci U S A (1991) 2.90

HLA restriction of cell-mediated lysis of influenza virus-infected human cells. Nature (1977) 2.88

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Cytotoxic T-cell recognition of HIV proteins and peptides. AIDS (1991) 2.83

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Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med (1994) 2.81

Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis (1997) 2.78

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Growth in the use of antibiotics in the community in England and Scotland in 1980-93. BMJ (1996) 2.74

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals. Int Immunol (1990) 2.71

Early effects of climate change: do they include changes in vector-borne disease? Philos Trans R Soc Lond B Biol Sci (2001) 2.71

HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J Immunol (2000) 2.69

Clearing the cataract backlog. Br J Ophthalmol (1987) 2.66

Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci. Proc Natl Acad Sci U S A (1992) 2.65

Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology (1999) 2.62