p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMC 99573)

Published in Mol Cell Biol on February 01, 2001

Authors

S L Green1, R A Freiberg, A J Giaccia

Author Affiliations

1: Center for Clinical Sciences Research, Department of Radiation Oncology, Stanford University, Stanford, California 94303-5152, USA.

Articles citing this

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J (2004) 4.26

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol (2003) 3.10

Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol (2002) 2.03

ATM activation and signaling under hypoxic conditions. Mol Cell Biol (2008) 1.84

Oxygen deprivation causes suspended animation in the zebrafish embryo. Proc Natl Acad Sci U S A (2001) 1.56

Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem (2008) 1.51

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47

Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res (2005) 1.35

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res (2010) 1.35

Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition. Cancer Res (2009) 1.15

Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res (2007) 1.15

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13

MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol (2015) 0.98

Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS One (2011) 0.94

Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis. J Biol Chem (2009) 0.92

Conditional hypoxia inducible factor-1α induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol (2011) 0.92

Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Cell Biol (2003) 0.90

Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89

Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter. Proc Natl Acad Sci U S A (2014) 0.89

NPP-16/Nup50 function and CDK-1 inactivation are associated with anoxia-induced prophase arrest in Caenorhabditis elegans. Mol Biol Cell (2010) 0.85

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation. Oncogene (2011) 0.84

Angiogenesis: escape from hypoxia. Nat Med (2009) 0.82

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer (2015) 0.78

Significance of p27 as potential biomarker for intracellular oxidative status. Nutr Res Pract (2010) 0.76

Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles. PLoS One (2016) 0.75

Switching off malignant mesothelioma: exploiting the hypoxic microenvironment. Genes Cancer (2016) 0.75

Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem (2017) 0.75

Articles cited by this

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature (1998) 11.61

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A (1997) 5.95

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J (1992) 4.21

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res (1991) 4.12

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science (1996) 3.74

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev (1996) 3.61

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol (1994) 3.30

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol (1999) 2.25

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell (1995) 2.18

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc Natl Acad Sci U S A (1993) 2.12

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc Natl Acad Sci U S A (1999) 2.10

A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr Biol (1999) 1.70

Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem (1997) 1.42

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: possible regulation mechanism. Biochem Biophys Res Commun (1983) 1.27

Tumor tissue oxygenation as evaluated by computerized-pO2-histography. Int J Radiat Oncol Biol Phys (1990) 1.26

Transforming growth factor-beta1 up-regulates p15, p21 and p27 and blocks cell cycling in G1 in human prostate epithelium. J Endocrinol (1999) 1.17

Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. Cancer J Sci Am (1998) 1.16

Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities. Oncogene (1998) 1.12

Oxygen modulates growth of human cells at physiologic partial pressures. J Exp Med (1984) 1.03

Induction of p21WAF/CIP1 during hyperoxia. Am J Respir Cell Mol Biol (1998) 1.03

Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells. Br J Cancer (1999) 1.01

Association of G1/S-phase and late S-phase checkpoints with regulation of cyclin-dependent kinases in Chinese hamster ovary cells. Radiat Res (1997) 0.98

Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression. Oncogene (1993) 0.98

Fast control of DNA replication in response to hypoxia and to inhibited protein synthesis in CCRF-CEM and HeLa cells. Biol Chem (1999) 0.96

Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo. Cancer Res (1988) 0.96

Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected. Cancer Res (1996) 0.96

The retinoblastoma gene product is reversibly dephosphorylated and bound in the nucleus in S and G2 phases during hypoxic stress. Exp Cell Res (1996) 0.94

The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein. Br J Cancer (1998) 0.93

Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia. Br J Cancer (1990) 0.91

Selective and synchronous activation of early-S-phase replicons of Ehrlich ascites cells. Mol Cell Biol (1993) 0.91

Oxygen dependent regulation of mammalian ribonucleotide reductase in vivo and possible significance for replicon initiation. Biochem Biophys Res Commun (1989) 0.89

Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension. Exp Cell Res (1987) 0.87

Reversible shutdown of replicon initiation by transient hypoxia in Ehrlich ascites cells. Dependence of initiation on short-lived protein. Eur J Biochem (1992) 0.86

A cytokinetic approach to determine the range of O2-dependence of pyrimidine(deoxy)nucleotide biosynthesis relevant for cell proliferation. Cell Prolif (1992) 0.85

Characterization of the deoxynucleoside-dependent reversal of hypoxia-induced inhibition of cell cycle progression in Ehrlich ascites tumor cells. Eur J Cell Biol (1985) 0.83

p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Exp Cell Res (2000) 0.83

Articles by these authors

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res (1998) 5.86

The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ (2008) 4.31

Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev (2000) 4.24

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A (1991) 3.69

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol (1994) 3.30

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (1999) 2.96

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood (1997) 2.37

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proc Natl Acad Sci U S A (1994) 2.15

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res (1994) 2.02

Candidate genes for the hypoxic tumor phenotype. Cancer Res (2000) 1.94

Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis. Cancer Res (2001) 1.80

Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther (2000) 1.75

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther (1997) 1.71

Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Gene Ther (1996) 1.66

Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res (2001) 1.60

Heat shock protein 72 modulates pathways of stress-induced apoptosis. J Biol Chem (1998) 1.55

Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res (2001) 1.45

Extensive localized bone resorption in the femur following total hip replacement. J Bone Joint Surg Am (1976) 1.45

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A (1996) 1.44

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock. Infect Immun (1993) 1.42

Tumour hypoxia: the picture has changed in the 1990s. Int J Radiat Biol (1994) 1.38

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res (1996) 1.38

Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther (2002) 1.37

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem (1999) 1.34

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A (1998) 1.24

Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int J Radiat Oncol Biol Phys (1994) 1.23

Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res (1999) 1.23

Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res (1997) 1.19

Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells. Cancer Res (1995) 1.18

Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. Cancer J Sci Am (1998) 1.16

NF-kappaB determines localization and features of cell death in epidermis. J Clin Invest (2000) 1.15

Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res (2000) 1.12

Modulation of c-Myc activity and apoptosis in vivo. Cancer Res (1996) 1.07

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proc Natl Acad Sci U S A (1993) 1.07

Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology (1999) 1.05

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Oncogene (1999) 1.04

p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts. Cell Death Differ (1998) 1.03

PHD2 in tumour angiogenesis. Br J Cancer (2010) 1.02

Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J Clin Endocrinol Metab (1999) 1.00

The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Clin Cancer Res (2004) 0.99

The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Radiat Res (1994) 0.96

Highly conserved RNA sequences that are sensors of environmental stress. Mol Cell Biol (1998) 0.95

Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab (2001) 0.95

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res (1997) 0.93

Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents. Cancer Res (1995) 0.92

Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res (1998) 0.92

Secondhand smoke, hypofibrinolysis, and Legg-Perthes disease. Clin Orthop Relat Res (1998) 0.92

The scallop sign and spontaneous rupture of finger extensor tendons in rheumatoid arthritics. Clin Orthop Relat Res (1972) 0.91

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res (1994) 0.91

Chromosomal radiosensitivity at intrachromosomal telomeric sites. Genes Chromosomes Cancer (1993) 0.89

p53 promotes selection for Fas-mediated apoptotic resistance. Cancer Res (2000) 0.87

Bilateral carpal tunnel syndrome secondary to gouty tenosynovitis: a case report. Clin Orthop Relat Res (1976) 0.86

Core decompression as a novel treatment for early Freiberg's infraction of the second metatarsal head. Orthopedics (1995) 0.85

Multiple intraosseous lipomas with type-IV hyperlipoproteinemia. A case report. J Bone Joint Surg Am (1974) 0.85

The use of aspirin to prevent heterotopic ossification after total hip arthroplasty. A preliminary report. Clin Orthop Relat Res (1991) 0.84

Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. Br J Cancer (1992) 0.83

p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Exp Cell Res (2000) 0.83

The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage. Br J Cancer (1991) 0.82

Genetic determinants that influence hypoxia-induced apoptosis. Novartis Found Symp (2001) 0.82

Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. J Clin Endocrinol Metab (2000) 0.81

Acidosis reduces neuronal apoptosis. Neuroreport (1998) 0.81

Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. Int J Hyperthermia (1994) 0.79

Molecular cloning of the breakpoint region on chromosome 6 in cutaneous malignant melanoma: evidence for deletion in the c-myb locus and translocation of a segment of chromosome 12. Oncogene (1989) 0.79

The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury. Brain Res (1998) 0.79

Analysis of restriction enzyme-induced chromosomal aberrations by fluorescence in situ hybridization. Environ Mol Mutagen (1993) 0.79

Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. J Clin Endocrinol Metab (2000) 0.78

Anticoagulant therapy for osteonecrosis associated with heritable hypofibrinolysis and thrombophilia. Expert Opin Investig Drugs (2001) 0.78

New directions for radiation biology research in cancer of the uterine cervix. J Natl Cancer Inst Monogr (1996) 0.78

Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation. Neurol Res (1996) 0.77

Genetically modified clostridium for gene therapy of tumors. Methods Mol Med (2000) 0.77

Modulation of potassium channels by protein tyrosine kinase inhibitors. J Cell Physiol (1994) 0.77

Measurement of the relative proportion of symmetrical and asymmetrical chromosome-type interchanges induced by gamma radiation in human-hamster hybrid cells. Radiat Res (1990) 0.76

Loss of the intrinsic heat resistance of human cells and changes in Mr 70,000 heat shock protein expression in human x hamster hybrids. Cancer Res (1991) 0.76

Cancer therapy and tumor physiology. Science (1998) 0.75

Rapidly progressing hip disease. Am J Orthop (Belle Mead NJ) (2001) 0.75

Evaluation of McKeever tibial plateau arthroplasty of the rheumatoid knee. Ohio State Med J (1974) 0.75

Heat sensitivity of bleomycin-sensitive CHO derivatives is not due to improper initialization of heat shock response. Int J Hyperthermia (1993) 0.75

What role do glutathione S-transferases play in the cellular response to ionizing radiation? Int J Radiat Oncol Biol Phys (1992) 0.75

The hip lifter. An aid to total hip-replacement arthroplasty performed in the supine position. J Bone Joint Surg Am (1975) 0.75

Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. J Cell Physiol (1993) 0.75

Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells. Int J Radiat Oncol Biol Phys (1994) 0.75