Published in Proc Natl Acad Sci U S A on February 02, 1999
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Nuclear organization of DNA replication in primary mammalian cells. Genes Dev (2000) 2.48
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17
RB-dependent S-phase response to DNA damage. Mol Cell Biol (2000) 2.08
MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol (2004) 1.89
Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol (2001) 1.78
p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol Biol Cell (2007) 1.54
p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol (2001) 1.53
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J (2007) 1.52
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J (2007) 1.36
p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A (2008) 1.31
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A (2010) 1.26
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. Elife (2014) 1.26
Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol Cell Biol (2000) 1.19
Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1. J Biol Chem (2009) 1.18
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol (2006) 1.16
Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes. BMC Bioinformatics (2007) 1.14
p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol (2007) 1.11
Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region. Biochem J (2006) 1.08
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A (2007) 1.07
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem (2010) 1.06
A systems biology dynamical model of mammalian G1 cell cycle progression. Mol Syst Biol (2007) 1.05
CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage. Cell Cycle (2013) 1.04
Anti-angiogenic and antitumor activities of Huaier aqueous extract. Oncol Rep (2012) 1.03
DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol (2011) 1.03
Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier. Int J Cancer (2010) 0.98
Nucleophosmin blocks mitochondrial localization of p53 and apoptosis. J Biol Chem (2009) 0.97
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer (2013) 0.96
Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury. Am J Physiol Gastrointest Liver Physiol (2008) 0.95
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. DNA Repair (Amst) (2011) 0.94
Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo. Stem Cells (2012) 0.94
MicroRNA-17~92 is required for nephrogenesis and renal function. J Am Soc Nephrol (2014) 0.93
E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol Cell Biol (2000) 0.93
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res (2008) 0.91
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. Mol Biol Cell (2009) 0.91
p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell. BMC Cancer (2010) 0.91
The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes. Oncogene (2005) 0.91
The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway. PLoS One (2012) 0.88
c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation. Cancer Res (2008) 0.87
Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. Radiat Oncol (2007) 0.87
Combining mTOR inhibition with radiation improves antitumor activity in bladder cancer cells in vitro and in vivo: a novel strategy for treatment. PLoS One (2013) 0.86
Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. J Virol (2001) 0.85
Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep (2016) 0.83
Galectin-3 regulates p21 stability in human prostate cancer cells. Oncogene (2012) 0.83
Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol (2010) 0.82
Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response. PLoS One (2012) 0.82
Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development. J Mol Histol (2012) 0.81
Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells. Cancer Cell Int (2010) 0.81
A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS One (2011) 0.81
Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment. J Cancer Res Clin Oncol (2009) 0.81
Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest. J Clin Biochem Nutr (2009) 0.80
Skin Tumors Rb(eing) Uncovered. Front Oncol (2013) 0.80
The Silencing Effect of microRNA miR-17 on p21 Maintains the Neural Progenitor Pool in the Developing Cerebral Cortex. Front Neurol (2014) 0.79
A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases. J Biol Chem (2013) 0.78
Effect of methotrexate on cerebellar development in infant rats. J Vet Med Sci (2015) 0.78
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia. Oncogene (2013) 0.78
Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol Cell Biol (2001) 0.78
TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. Oncogene (2017) 0.77
hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism. Oncotarget (2016) 0.77
Distinct and site-specific phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells. PLoS One (2014) 0.76
PTTG1 regulated by miR-146-3p promotes bladder cancer migration, invasion, metastasis and growth. Oncotarget (2016) 0.75
The expanding role of the Ehmt2/G9a complex in neurodevelopment. Neurogenesis (Austin) (2017) 0.75
UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol (2015) 0.75
Ki-67 contributes to normal cell cycle progression and inactive X heterochromatin in p21 checkpoint-proficient human cells. Mol Cell Biol (2017) 0.75
Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo. J Immunol (2017) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61
D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol (1994) 7.35
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell (1994) 7.05
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41
Retinoblastoma protein switches the E2F site from positive to negative element. Nature (1992) 5.47
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature (1993) 5.31
Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol (1994) 5.18
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (1995) 4.78
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol (1998) 4.54
When checkpoints fail. Cell (1997) 4.21
Mechanism of active transcriptional repression by the retinoblastoma protein. Nature (1995) 4.05
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem (1997) 3.18
Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol (1995) 3.16
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev (1997) 2.83
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell (1997) 2.67
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev (1997) 2.65
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A (1998) 2.49
Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science (1995) 2.42
Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv (1992) 2.29
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A (1995) 2.27
Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A (1997) 1.67
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation. Nature (1995) 1.55
Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem (1996) 1.44
Role of the Rb/E2F pathway in cell growth control. J Cell Physiol (1997) 1.44
The retinoblastoma gene and gene product. Cancer Surv (1992) 1.42
UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints. Oncogene (1996) 1.07
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst (2000) 16.92
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell (1992) 7.06
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev (2000) 6.54
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J (1992) 4.69
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell (1994) 4.22
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev (1993) 4.14
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc Natl Acad Sci U S A (1987) 3.84
Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83
p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69
ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet (1998) 3.66
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev (1994) 3.47
Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol (1996) 3.40
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell (1990) 3.37
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene (2001) 3.36
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
E2f3 is critical for normal cellular proliferation. Genes Dev (2000) 3.26
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15
Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol (2000) 3.12
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet (1996) 3.08
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol (2000) 3.07
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell (1998) 3.05
The retinoblastoma gene family in differentiation and development. Oncogene (1999) 2.95
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol (1999) 2.79
Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet (1994) 2.73
Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol (1996) 2.71
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev (1998) 2.66
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci U S A (2001) 2.65
Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J (1996) 2.63
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
The retinoblastoma gene family: cousins with overlapping interests. Trends Genet (1998) 2.59
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
Structural organization and expression of the mouse estrogen receptor. Mol Endocrinol (1987) 2.54
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet (1998) 2.53
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J (1999) 2.50
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell (2001) 2.47
Hypoglycemia in hospitalized patients. Causes and outcomes. N Engl J Med (1986) 2.44
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J (2000) 2.38
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33
E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol (1997) 2.33
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am J Pathol (2000) 2.27
Stenosis of the afferent antireflux valve in the Kock pouch continent urinary diversion: diagnosis and management. J Urol (1994) 2.24
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell (2000) 2.21
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol (2001) 2.19
E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev (2001) 2.16
The role of radical cystectomy in the management of high grade superficial bladder cancer (PA, P1, PIS and P2) J Urol (1990) 2.07
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol (2000) 2.05
Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells. Nucleic Acids Res (1982) 2.01
In vivo association of E2F and DP family proteins. Mol Cell Biol (1995) 1.99
E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci U S A (1998) 1.99
Modeling human lung cancer in mice: similarities and shortcomings. Oncogene (1999) 1.98
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol (2003) 1.86
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res (1999) 1.85
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev (1993) 1.84
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. J Exp Med (1998) 1.82
The role of adjuvant chemotherapy following cystectomy for invasive bladder cancer: a prospective comparative trial. J Urol (1991) 1.81
A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res (2000) 1.74
The cell cycle and cancer. Proc Natl Acad Sci U S A (1997) 1.72
Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J (1982) 1.71
Vena caval involvement by renal cell carcinoma. Surgical resection provides meaningful long-term survival. Ann Surg (1989) 1.71