Published in Cell on December 22, 2000
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet (2004) 7.50
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol (2004) 6.72
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97
Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A (2008) 5.94
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Sleep state switching. Neuron (2010) 4.94
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev (2006) 4.90
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science (2012) 4.77
microRNA modulation of circadian-clock period and entrainment. Neuron (2007) 4.49
The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol (2008) 4.43
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Natl Acad Sci U S A (2005) 3.12
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol (2011) 2.94
Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell (2007) 2.94
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis. Plant Cell (2003) 2.86
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci (2007) 2.84
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry (2010) 2.77
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc Natl Acad Sci U S A (2005) 2.67
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res (2010) 2.49
The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev (2010) 2.42
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science (2006) 2.41
The circadian molecular clock creates epidermal stem cell heterogeneity. Nature (2011) 2.34
The circadian clock coordinates ribosome biogenesis. PLoS Biol (2013) 2.31
Expression of Period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker. J Neurosci (2001) 2.30
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci U S A (2007) 2.22
Differential rescue of light- and food-entrainable circadian rhythms. Science (2008) 2.20
Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy. Curr Biol (2004) 2.17
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13
Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene. EMBO J (2001) 2.11
Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science (2012) 1.97
Circadian clock proteins control adaptation to novel environment and memory formation. Aging (Albany NY) (2010) 1.95
Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol (2010) 1.94
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell (2016) 1.91
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A (2005) 1.91
The circadian clock and pathology of the ageing brain. Nat Rev Neurosci (2012) 1.90
Circadian control of the immune system. Nat Rev Immunol (2013) 1.90
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol (2004) 1.89
Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle (2011) 1.87
Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock. Proc Natl Acad Sci U S A (2009) 1.86
Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A (2007) 1.84
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83
Vascular disease in mice with a dysfunctional circadian clock. Circulation (2009) 1.82
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. Elife (2012) 1.82
A role for cryptochromes in sleep regulation. BMC Neurosci (2002) 1.81
Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell (2009) 1.79
In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes. Crit Care Med (2010) 1.76
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes Dev (2009) 1.75
BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol Cell Biol (2006) 1.74
Circadian disruption leads to insulin resistance and obesity. Curr Biol (2013) 1.66
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
Attenuated circadian rhythms in mice lacking the prokineticin 2 gene. J Neurosci (2006) 1.63
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY) (2011) 1.61
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev (2002) 1.56
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52
Finding new clock components: past and future. J Biol Rhythms (2004) 1.50
Clock genes control cortical critical period timing. Neuron (2015) 1.50
Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture. Curr Biol (2014) 1.50
Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet (2009) 1.49
BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) (2014) 1.48
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Modeling feedback loops of the Mammalian circadian oscillator. Biophys J (2004) 1.45
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One (2010) 1.45
Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One (2010) 1.44
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology (2009) 1.43
Robust food anticipatory activity in BMAL1-deficient mice. PLoS One (2009) 1.43
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock. PLoS Biol (2015) 1.42
Circadian regulation of ATP release in astrocytes. J Neurosci (2011) 1.41
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype. Bone (2016) 1.41
The BMAL1 C terminus regulates the circadian transcription feedback loop. Proc Natl Acad Sci U S A (2006) 1.41
Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice. Proc Natl Acad Sci U S A (2014) 1.41
Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock. Mol Biol Cell (2005) 1.41
When clocks go bad: neurobehavioural consequences of disrupted circadian timing. PLoS Genet (2008) 1.41
Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity (2017) 1.38
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. J Biol Chem (2010) 1.36
Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol (2010) 1.35
Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Curr Biol (2010) 1.34
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun (2015) 1.31
Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci (2003) 1.30
The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythms (2008) 1.30
Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. Breast Cancer Res Treat (2007) 1.30
Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. PLoS One (2010) 1.29
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One (2009) 1.29
Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1. Genes Dev (2010) 1.28
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol (2010) 1.28
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation. Cell Cycle (2009) 1.27
The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. Mol Cancer Res (2008) 1.27
Genetic differences in human circadian clock genes among worldwide populations. J Biol Rhythms (2008) 1.27
Efficient characterization of high-dimensional parameter spaces for systems biology. BMC Syst Biol (2011) 1.26
Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol (2008) 1.23
Real time quantitative PCR. Genome Res (1996) 35.79
Molecular bases for circadian clocks. Cell (1999) 13.96
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
Resetting central and peripheral circadian oscillators in transgenic rats. Science (2000) 8.63
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell (1999) 8.38
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature (1999) 7.86
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science (1994) 7.83
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
Transplanted suprachiasmatic nucleus determines circadian period. Science (1990) 5.55
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell (1997) 5.51
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell (1998) 5.10
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science (2000) 4.94
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell (1998) 4.81
The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol (2000) 4.79
The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (1999) 4.74
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell (1998) 4.59
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science (1999) 4.43
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell (1998) 4.22
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A (1998) 4.20
Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science (1999) 4.09
A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell (1999) 4.08
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem (1997) 3.67
Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock. Science (1999) 3.42
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science (1994) 3.24
Molecular genetics of circadian rhythms in mammals. Annu Rev Neurosci (2000) 2.96
A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature (1996) 2.92
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev (2000) 2.84
Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol (2000) 2.69
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol (1999) 2.29
The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J (1997) 2.17
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A (1997) 2.15
Impaired cued and contextual memory in NPAS2-deficient mice. Science (2000) 2.14
A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol Cell Biol (1997) 2.11
Circadian rhythms: basic neurobiology and clinical applications. Annu Rev Med (1997) 1.97
Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol Cell Biol (1998) 1.96
A clockwork explosion! Neuron (1998) 1.66
Circadian rhythm genetics: from flies to mice to humans. Nat Genet (2000) 1.66
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun (1997) 1.61
A time-less function for mouse timeless. Nat Neurosci (2000) 1.53
Masking of locomotor activity in hamsters. J Comp Physiol A (1999) 1.47
Differential elimination of circadian and ultradian rhythmicity by hypothalamic lesions in the common vole, Microtus arvalis. J Biol Rhythms (1990) 1.39
Phase control of ultradian feeding rhythms in the common vole (Microtus arvalis): the roles of light and the circadian system. J Biol Rhythms (1993) 1.38
Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus. Biochem Biophys Res Commun (1998) 1.36
Circadian rhythms: molecular basis of the clock. Curr Opin Genet Dev (1998) 1.35
PAS, present, and future: clues to the origins of circadian clocks. Science (1997) 1.28
The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. J Neurosci (2000) 1.27
Masking by light in hamsters with SCN lesions. J Comp Physiol A (1999) 1.21
Lesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse. Physiol Behav (1991) 1.17
Light and glutamate-induced degradation of the circadian oscillating protein BMAL1 during the mammalian clock resetting. J Neurosci (2000) 1.14
Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem Biophys Res Commun (1998) 1.10
Stochastic principles in the temporal control of activity behaviour. Int J Chronobiol (1977) 1.08
cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization. Biochem Biophys Res Commun (2000) 1.00
Characterization of three splice variants and genomic organization of the mouse BMAL1 gene. Biochem Biophys Res Commun (1999) 0.99
Molecular control of circadian rhythms. Curr Opin Genet Dev (1995) 0.99
Suprachiasmatic nuclei lesions do not eliminate homeostatic thermoregulatory responses in rats. J Biol Rhythms (1997) 0.90
Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science (2000) 12.35
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell (1996) 10.44
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science (2005) 9.25
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science (1994) 7.83
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science (1994) 7.60
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell (1997) 5.51
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A (1992) 5.28
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science (2000) 4.94
The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol (2000) 4.79
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A (1996) 4.66
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature (1997) 4.36
A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes. Cell (2001) 4.36
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A (1998) 4.20
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol (1993) 4.13
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature (1998) 4.03
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem (1997) 3.67
Ah receptor signaling pathways. Annu Rev Cell Dev Biol (1996) 3.60
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev (1997) 3.33
Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res (2001) 3.04
Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev (1998) 3.04
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science (1993) 3.03
Molecular genetics of circadian rhythms in mammals. Annu Rev Neurosci (2000) 2.96
DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J Biol Chem (1995) 2.91
Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat Neurosci (1998) 2.89
Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A (2001) 2.87
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr (1998) 2.82
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Proc Natl Acad Sci U S A (1993) 2.80
Development of hematopoietic cells lacking transcription factor GATA-1. Development (1995) 2.78
Course of acute renal failure studied by a model of creatinine kinetics. Kidney Int (1985) 2.69
Sequence interpretation. Functional annotation of mouse genome sequences. Science (2001) 2.54
Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A (1994) 2.44
Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci (2001) 2.44
Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron (1998) 2.42
The AH-receptor: genetics, structure and function. Pharmacogenetics (1993) 2.41
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science (1998) 2.38
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev (2000) 2.32
A CLOCK polymorphism associated with human diurnal preference. Sleep (1998) 2.24
Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A (2000) 2.22
A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol Cell Biol (1997) 2.20
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development (1995) 2.19
The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci (2000) 2.17
Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron (1999) 2.15
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene (2009) 2.14
Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ (2008) 2.08
Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus). J Physiol (1991) 2.06
Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J Biol Chem (1997) 2.04
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A (1991) 2.03
Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms. Nature (1984) 1.94
Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet (2000) 1.92
Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev (1999) 1.92
Multiple sequence elements in the c-fos promoter mediate induction by cAMP. Genes Dev (1989) 1.76
Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus. Neuron (1990) 1.76
The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. Genetics (1997) 1.75
Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J (1997) 1.73
Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am J Physiol (1997) 1.73
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity (1995) 1.72
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol (1994) 1.70
Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes (1996) 1.65
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature (1996) 1.65
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity (1997) 1.64
Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior. Cell (2001) 1.62
Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins. Mol Cell Biol (1995) 1.60
Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. J Biol Chem (1994) 1.59
Cloning and expression of a human Ah receptor cDNA. Mol Pharmacol (1993) 1.57
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet (2000) 1.56
Identification of toxicologically predictive gene sets using cDNA microarrays. Mol Pharmacol (2001) 1.52
The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation. J Virol (1989) 1.50
A common pathway for dendritic cell and early B cell development. J Immunol (2001) 1.50
Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture. Neuron (1993) 1.47
High-resolution time course analysis of gene expression from pituitary. Cold Spring Harb Symp Quant Biol (2007) 1.45
PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity (1999) 1.40
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A (2001) 1.39
The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis. Recent Prog Horm Res (1989) 1.37
Circadian rhythms: molecular basis of the clock. Curr Opin Genet Dev (1998) 1.35
Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. J Biol Chem (1999) 1.35
Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. Proc Natl Acad Sci U S A (1998) 1.32
Gotta have GATA. Nat Genet (1995) 1.31
The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med (1996) 1.30
The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system. J Biol Chem (1994) 1.30
Ahr null alleles: distinctive or different? Biochem Pharmacol (1998) 1.29
The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. J Neurosci (2000) 1.27
Genetic determinants of neoplastic diseases induced by a subgroup F avian leukosis virus. J Virol (1987) 1.26