Published in Science on August 30, 2012
A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A (2014) 4.22
Reprogramming of the circadian clock by nutritional challenge. Cell (2013) 2.47
Molecular architecture of the mammalian circadian clock. Trends Cell Biol (2013) 2.26
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol (2012) 2.12
T cell metabolism drives immunity. J Exp Med (2015) 2.06
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A (2013) 1.94
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell (2016) 1.91
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. Elife (2012) 1.82
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science (2015) 1.82
Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. Cell Metab (2012) 1.77
Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology (2015) 1.63
Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation. Nat Biotechnol (2015) 1.62
Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proc Natl Acad Sci U S A (2013) 1.55
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol (2015) 1.55
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev (2014) 1.54
In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet (2014) 1.54
High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast. Nat Struct Mol Biol (2014) 1.53
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol (2014) 1.52
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab (2016) 1.48
Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol (2013) 1.47
Circadian Control of Global Transcription. Biomed Res Int (2015) 1.42
Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice. Proc Natl Acad Sci U S A (2014) 1.41
TH17 cell differentiation is regulated by the circadian clock. Science (2013) 1.37
Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression. Genes Dev (2012) 1.33
Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci U S A (2014) 1.30
Circadian timekeeping and output mechanisms in animals. Curr Opin Neurobiol (2013) 1.30
Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab (2014) 1.29
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
Emerging roles for post-transcriptional regulation in circadian clocks. Nat Neurosci (2013) 1.28
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep (2015) 1.19
Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver. Cell Metab (2016) 1.17
Circadian control of global gene expression by the cyanobacterial master regulator RpaA. Cell (2013) 1.14
Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell (2014) 1.14
CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev (2014) 1.13
Histone methyltransferase MLL3 contributes to genome-scale circadian transcription. Proc Natl Acad Sci U S A (2013) 1.11
Mechanism of the circadian clock in physiology. Am J Physiol Regul Integr Comp Physiol (2013) 1.09
MYC and metabolism on the path to cancer. Semin Cell Dev Biol (2015) 1.09
Circadian clocks and neurodegenerative diseases: time to aggregate? Curr Opin Neurobiol (2013) 1.07
Nascent-Seq analysis of Drosophila cycling gene expression. Proc Natl Acad Sci U S A (2013) 1.06
Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse. Proc Natl Acad Sci U S A (2013) 1.06
A genome-scale resource for the functional characterization of Arabidopsis transcription factors. Cell Rep (2014) 1.05
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol (2014) 1.05
SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep (2014) 1.05
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes Dev (2014) 1.03
Small molecule modifiers of circadian clocks. Cell Mol Life Sci (2012) 1.03
The circadian clock gates the intestinal stem cell regenerative state. Cell Rep (2013) 1.02
Chronopharmacology: new insights and therapeutic implications. Annu Rev Pharmacol Toxicol (2013) 1.02
Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus. J Neuroendocrinol (2014) 1.02
High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One (2014) 1.01
Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus. Nat Struct Mol Biol (2015) 1.00
Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential. Proc Natl Acad Sci U S A (2014) 1.00
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression. BMC Med (2013) 0.99
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver. Proc Natl Acad Sci U S A (2015) 0.99
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun (2016) 0.98
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice. Elife (2013) 0.98
The circadian epigenome: how metabolism talks to chromatin remodeling. Curr Opin Cell Biol (2013) 0.98
Emerging models for the molecular basis of mammalian circadian timing. Biochemistry (2014) 0.98
Local renal circadian clocks control fluid-electrolyte homeostasis and BP. J Am Soc Nephrol (2014) 0.97
Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis. Proc Natl Acad Sci U S A (2015) 0.97
Circadian clocks in the cnidaria: environmental entrainment, molecular regulation, and organismal outputs. Integr Comp Biol (2013) 0.97
CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus. EMBO Rep (2013) 0.96
Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol (2013) 0.96
A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia (2015) 0.95
Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J Neurosci (2013) 0.95
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab (2016) 0.95
Nutrients, Clock Genes, and Chrononutrition. Curr Nutr Rep (2014) 0.95
A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A (2013) 0.95
MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale. Elife (2014) 0.94
CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes. Mol Cell Biol (2014) 0.94
Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab (2015) 0.94
Ordered changes in histone modifications at the core of the Arabidopsis circadian clock. Proc Natl Acad Sci U S A (2012) 0.93
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes. Mol Cell (2016) 0.93
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med (2016) 0.92
Transcriptional interference by antisense RNA is required for circadian clock function. Nature (2014) 0.92
Long Noncoding RNAs: A New Regulatory Code in Metabolic Control. Trends Biochem Sci (2015) 0.92
Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metab (2015) 0.92
Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc Natl Acad Sci U S A (2013) 0.91
Metabolic and nontranscriptional circadian clocks: eukaryotes. Annu Rev Biochem (2014) 0.91
Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J (2013) 0.91
Tracking circadian rhythms of bone mineral deposition in murine calvarial organ cultures. J Bone Miner Res (2013) 0.90
Aging signaling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab (2013) 0.90
Intrinsic muscle clock is necessary for musculoskeletal health. J Physiol (2015) 0.90
24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. PLoS Genet (2014) 0.90
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney. Am J Physiol Regul Integr Comp Physiol (2013) 0.90
Circadian clocks, epigenetics, and cancer. Curr Opin Oncol (2015) 0.89
Nuclear receptors rock around the clock. EMBO Rep (2014) 0.89
Circadian regulation of adipose function. Adipocyte (2013) 0.89
Circadian clock disruption in neurodegenerative diseases: cause and effect? Front Pharmacol (2015) 0.88
Molecular components of the circadian clock in mammals. Diabetes Obes Metab (2015) 0.88
Characteristic bimodal profiles of RNA polymerase II at thousands of active mammalian promoters. Genome Biol (2014) 0.88
Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet (2014) 0.88
Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome. Proc Natl Acad Sci U S A (2015) 0.88
Circadian regulation of cellular physiology. Methods Enzymol (2015) 0.87
Circadian rhythms and addiction: mechanistic insights and future directions. Behav Neurosci (2014) 0.87
LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator. Plant Cell (2014) 0.87
Circadian rhythms, the molecular clock, and skeletal muscle. J Biol Rhythms (2014) 0.87
Timing of circadian genes in mammalian tissues. Sci Rep (2014) 0.87
Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab (2016) 0.87
The day/night proteome in the murine heart. Am J Physiol Regul Integr Comp Physiol (2014) 0.87
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39
The human genome browser at UCSC. Genome Res (2002) 168.23
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
The role of chromatin during transcription. Cell (2007) 26.48
A high-resolution map of active promoters in the human genome. Nature (2005) 24.35
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science (2008) 16.48
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02
WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res (2005) 12.88
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A (2004) 12.43
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Role of the CLOCK protein in the mammalian circadian mechanism. Science (1998) 10.03
Extensive and divergent circadian gene expression in liver and heart. Nature (2002) 9.64
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
Mop3 is an essential component of the master circadian pacemaker in mammals. Cell (2000) 8.72
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell (1999) 8.38
Posttranslational mechanisms regulate the mammalian circadian clock. Cell (2001) 7.93
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Circadian integration of metabolism and energetics. Science (2010) 6.86
A transcription factor response element for gene expression during circadian night. Nature (2002) 6.55
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
Harmonics of circadian gene transcription in mammals. PLoS Genet (2009) 4.97
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science (1999) 4.43
Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature (2009) 4.31
Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature (2002) 4.13
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99
NPAS2: an analog of clock operative in the mammalian forebrain. Science (2001) 3.88
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms (2010) 3.42
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27
Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation. Biotechniques (2005) 3.11
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol (2011) 2.94
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev (2012) 2.83
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain. Nat Struct Mol Biol (2011) 2.73
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem (2005) 2.68
PeakAnalyzer: genome-wide annotation of chromatin binding and modification loci. BMC Bioinformatics (2010) 2.65
In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques (2006) 2.46
C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats. J Biol Chem (2004) 2.42
The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev (2010) 2.42
Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol (1996) 2.40
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
Clocks, metabolism, and the epigenome. Mol Cell (2012) 1.84
Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell (2009) 1.79
The role of the transcriptional activator protein DBP in circadian liver gene expression. J Cell Sci Suppl (1992) 1.76
Post-transcriptional control of circadian rhythms. J Cell Sci (2011) 1.72
Role for antisense RNA in regulating circadian clock function in Neurospora crassa. Nature (2003) 1.70
Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics. J Biol Rhythms (2007) 1.64
A molecular mechanism for circadian clock negative feedback. Science (2011) 1.64
Analyzing circadian expression data by harmonic regression based on autoregressive spectral estimation. Bioinformatics (2010) 1.63
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev (2010) 1.57
Understanding systems-level properties: timely stories from the study of clocks. Nat Rev Genet (2011) 1.51
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol (2004) 1.49
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol (2010) 1.35
Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1. Genes Dev (2010) 1.28
Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem (2011) 1.27
Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock. J Cell Sci (2010) 1.12
Spotlight on post-transcriptional control in the circadian system. Cell Mol Life Sci (2010) 1.06
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription. Mol Brain (2009) 0.95
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A (2004) 12.43
Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72
Molecular components of the mammalian circadian clock. Hum Mol Genet (2006) 7.51
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet (2004) 7.50
Circadian integration of metabolism and energetics. Science (2010) 6.86
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97
The meter of metabolism. Cell (2008) 5.71
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell (2007) 4.87
Temperature as a universal resetting cue for mammalian circadian oscillators. Science (2010) 4.85
Central and peripheral circadian clocks in mammals. Annu Rev Neurosci (2012) 4.73
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (2006) 4.68
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr Biol (2004) 4.49
Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol (2010) 4.38
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature (2002) 4.13
Activity-dependent regulation of inhibitory synapse development by Npas4. Nature (2008) 4.10
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science (2008) 4.02
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron (2008) 3.65
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc Natl Acad Sci U S A (2005) 2.67
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature (2012) 2.67
Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J (2009) 2.65
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science (2006) 2.41
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci U S A (2006) 2.36
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
Systematic evaluation of factors influencing ChIP-seq fidelity. Nat Methods (2012) 2.31
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res (2006) 2.26
Falciparum malaria presenting as subdural hematoma. J Assoc Physicians India (2011) 2.24
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 2.20
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science (2012) 2.20
Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy. Curr Biol (2004) 2.17
Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics (2007) 2.06
Genomewide association analysis in diverse inbred mice: power and population structure. Genetics (2007) 2.01
BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci (2006) 2.01
Sex- and lineage-specific inheritance of depression-like behavior in the rat. Mamm Genome (2004) 1.99
Real-time luminescence reporting of circadian gene expression in mammals. Methods Enzymol (2005) 1.98
Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo. Proc Natl Acad Sci U S A (2001) 1.96
Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol (2010) 1.94
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A (2005) 1.91
Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell (2009) 1.79
CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock. Proc Natl Acad Sci U S A (2009) 1.73
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
Anastomosis during robot-assisted radical prostatectomy: randomized controlled trial comparing barbed and standard monofilament suture. Urology (2011) 1.61
Circadian rhythm generation and entrainment in astrocytes. J Neurosci (2005) 1.59
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell (2013) 1.56
Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves. Am J Physiol Heart Circ Physiol (2004) 1.55
The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker. J Mol Endocrinol (2004) 1.50
Circadian clock genes contribute to the regulation of hair follicle cycling. PLoS Genet (2009) 1.49
Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol (2013) 1.47
Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol (2003) 1.44
Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle (2006) 1.43
Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci U S A (2009) 1.40
TH17 cell differentiation is regulated by the circadian clock. Science (2013) 1.37
Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J Neurochem (2008) 1.36
Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators. Trends Neurosci (2011) 1.36
Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Brain Res Mol Brain Res (2004) 1.36
Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle (2008) 1.35
C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science (2013) 1.31
Implementing large-scale ENU mutagenesis screens in North America. Genetica (2004) 1.31
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS Genet (2012) 1.27
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse. Vis Neurosci (2007) 1.27
Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile. J Biol Chem (2009) 1.25
The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A (2011) 1.24
Aging alters circadian and light-induced expression of clock genes in golden hamsters. J Biol Rhythms (2003) 1.23
Methods to record circadian rhythm wheel running activity in mice. Methods Enzymol (2005) 1.20
Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle (2005) 1.20
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A (2012) 1.19
Circadian transcriptional output in the SCN and liver of the mouse. Novartis Found Symp (2003) 1.15
Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior. PLoS Genet (2007) 1.15
Future of genetics of mood disorders research. Biol Psychiatry (2002) 1.11
Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron (2012) 1.11
Vasopressin regulation of the proestrous luteinizing hormone surge in wild-type and Clock mutant mice. Biol Reprod (2006) 1.11