Published in Science on January 12, 2001
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol (2008) 3.60
Independent optical excitation of distinct neural populations. Nat Methods (2014) 3.53
Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci (2014) 3.18
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell (2011) 2.69
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods (2014) 2.41
Optogenetic tools for analyzing the neural circuits of behavior. Trends Cogn Sci (2011) 2.15
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron (2012) 2.13
Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Regulation of G protein-coupled receptor export trafficking. Biochim Biophys Acta (2006) 1.99
Intracellular trafficking of the UL11 tegument protein of herpes simplex virus type 1. J Virol (2001) 1.90
Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A (2011) 1.76
Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure. Cell (2011) 1.71
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. J Cell Biol (2004) 1.70
N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. EMBO J (2003) 1.68
A history of optogenetics: the development of tools for controlling brain circuits with light. F1000 Biol Rep (2011) 1.59
The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis. J Biol Chem (2010) 1.55
Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane. Plant Cell (2006) 1.43
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol (2004) 1.42
Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with Sar1. Mol Biol Cell (2003) 1.41
An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export. EMBO J (2001) 1.36
Membrane receptor trafficking: evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals. Proc Natl Acad Sci U S A (2003) 1.33
An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca2+-activated K+ channel splice variant. Proc Natl Acad Sci U S A (2004) 1.31
Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol (2003) 1.30
Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels. J Gen Physiol (2002) 1.27
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci (2010) 1.25
Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol (2008) 1.25
The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER. EMBO J (2002) 1.24
Concentrative sorting of secretory cargo proteins into COPII-coated vesicles. J Cell Biol (2002) 1.23
KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia. Proc Natl Acad Sci U S A (2013) 1.21
Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J Biol Chem (2012) 1.21
Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1. J Gen Physiol (2006) 1.20
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK). Proc Natl Acad Sci U S A (2005) 1.15
Diacidic motifs influence the export of transmembrane proteins from the endoplasmic reticulum in plant cells. Plant Cell (2005) 1.14
Selective heteromeric assembly of cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (2003) 1.13
Mechanisms of cardiac potassium channel trafficking. J Physiol (2007) 1.09
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron (2012) 1.09
Targeting of a Nicotiana plumbaginifolia H+ -ATPase to the plasma membrane is not by default and requires cytosolic structural determinants. Plant Cell (2004) 1.07
Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization. Proc Natl Acad Sci U S A (2004) 1.07
Cell-surface targeting of alpha2-adrenergic receptors -- inhibition by a transport deficient mutant through dimerization. Cell Signal (2005) 1.07
The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. J Clin Invest (2002) 1.06
Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. J Biol Chem (2011) 1.05
C-terminal interaction of KCNQ2 and KCNQ3 K+ channels. J Physiol (2003) 1.05
A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2. J Biol Chem (2009) 1.04
Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels. J Physiol (2011) 1.02
Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface. J Biol Chem (2011) 1.02
MaxiK channel and cell signalling. Pflugers Arch (2014) 1.02
A specific role of AGS3 in the surface expression of plasma membrane proteins. Proc Natl Acad Sci U S A (2007) 1.02
Domain analysis of Kv6.3, an electrically silent channel. J Physiol (2005) 1.01
The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast. Mol Biol Cell (2009) 1.00
Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells. Mol Cell Biol (2008) 0.99
New putative chloroplast vesicle transport components and cargo proteins revealed using a bioinformatics approach: an Arabidopsis model. PLoS One (2013) 0.97
Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels. J Biol Chem (2011) 0.96
A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export. Traffic (2012) 0.95
Regulation of Kir2.1 channels by the Rho-GTPase, Rac1. J Cell Physiol (2009) 0.93
Diacidic motif is required for efficient transport of the K+ channel KAT1 to the plasma membrane. Plant Physiol (2006) 0.93
A new LxxxA motif in the transmembrane Helix3 of maize aquaporins belonging to the plasma membrane intrinsic protein PIP2 group is required for their trafficking to the plasma membrane. Plant Physiol (2014) 0.92
In vivo application of optogenetics for neural circuit analysis. ACS Chem Neurosci (2012) 0.92
Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic (2010) 0.92
Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochem Pharmacol (2006) 0.91
The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1. J Membr Biol (2010) 0.89
Concerted gating mechanism underlying KATP channel inhibition by ATP. Biophys J (2004) 0.89
AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling. PLoS One (2012) 0.88
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis. J Endocrinol (2009) 0.88
A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch (2013) 0.87
Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol (2011) 0.87
Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem (2010) 0.87
Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function. Biochem J (2002) 0.86
Synthetic physiology strategies for adapting tools from nature for genetically targeted control of fast biological processes. Methods Enzymol (2011) 0.85
Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation. J Physiol (2002) 0.85
N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta. BMC Cell Biol (2008) 0.85
Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron (2013) 0.84
An ER export signal accelerates the surface expression of shal potassium channels in pyloric neurons of the lobster stomatogastric ganglion. Pflugers Arch (2003) 0.83
Optogenetic techniques for the study of native potassium channels. Front Mol Neurosci (2013) 0.83
KATP Channels in the Cardiovascular System. Physiol Rev (2016) 0.82
Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2. J Biol Chem (2012) 0.82
Distinct amino acids in the C-linker domain of the Arabidopsis K+ channel KAT2 determine its subcellular localization and activity at the plasma membrane. Plant Physiol (2014) 0.82
A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C. J Biol Chem (2013) 0.81
The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflugers Arch (2015) 0.81
Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2. Am J Physiol Cell Physiol (2013) 0.81
Unparalleled control of neural activity using orthogonal pharmacogenetics. ACS Chem Neurosci (2012) 0.80
C-terminal region regulates the functional expression of human noradrenaline transporter splice variants. Biochem J (2007) 0.80
ESCRT regulates surface expression of the Kir2.1 potassium channel. Mol Biol Cell (2013) 0.80
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Mol Pain (2015) 0.79
Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine. Pflugers Arch (2012) 0.79
The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. PLoS One (2013) 0.79
Route to genetically targeted optical electrophysiology: development and applications of voltage-sensitive fluorescent proteins. Neurophotonics (2015) 0.79
Identification of endoplasmic reticulum export motifs for G protein-coupled receptors. Methods Enzymol (2013) 0.79
Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker. PLoS One (2012) 0.78
A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER. EMBO J (2014) 0.78
The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport. Biochem J (2004) 0.78
Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain. J Biol Chem (2014) 0.78
Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a. BMC Biochem (2015) 0.78
Cdo Regulates Surface Expression of Kir2.1 K+ Channel in Myoblast Differentiation. PLoS One (2016) 0.77
C-terminal determinants of Kir4.2 channel expression. J Membr Biol (2007) 0.77
Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. Br J Pharmacol (2014) 0.77
RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1. J Biol Chem (2014) 0.77
Regulation of post-Golgi traffic of G protein-coupled receptors. Subcell Biochem (2012) 0.77
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell (1989) 14.24
Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature (1993) 8.20
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron (1999) 6.13
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev (1994) 5.71
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature (1995) 5.54
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell (1994) 5.37
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) (1997) 5.03
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature (1994) 4.92
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature (1993) 4.81
Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 4.69
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature (1991) 4.60
Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science (1987) 4.48
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature (1988) 4.18
Properties of the larval neuromuscular junction in Drosophila melanogaster. J Physiol (1976) 4.18
A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron (2000) 3.98
daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell (1988) 3.94
Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature (1990) 3.88
A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell (1988) 3.87
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
dunce, a mutant of Drosophila deficient in learning. Proc Natl Acad Sci U S A (1976) 3.74
Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A (1982) 3.73
Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature (1991) 3.72
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. Neuron (1995) 3.70
Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature (1988) 3.69
Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science (1992) 3.53
G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron (1997) 3.52
Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science (1996) 3.35
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science (1987) 3.33
Reproductive cessation in female mammals. Nature (1998) 3.31
atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell (1993) 3.24
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron (1999) 3.15
Cloned potassium channels from eukaryotes and prokaryotes. Annu Rev Neurosci (1997) 3.11
Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis (2009) 3.11
Atonal is the proneural gene for Drosophila photoreceptors. Nature (1994) 3.11
L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J Physiol (1976) 3.01
Delta-aminolevulinic acid synthetase. II. Induction in rat liver. J Biol Chem (1966) 2.98
Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron (1992) 2.98
HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell (1993) 2.93
A peptide as a possible transmitter in sympathetic ganglia of the frog. Proc Natl Acad Sci U S A (1979) 2.89
Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88
Asymmetric segregation of Numb and Prospero during cell division. Nature (1995) 2.87
Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature (1996) 2.87
Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron (1996) 2.84
The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc Natl Acad Sci U S A (2002) 2.80
Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell (1989) 2.72
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell (1996) 2.69
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol (2001) 2.69
frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell (1996) 2.69
The problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory Angina. Eur Heart J (2002) 2.68
Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila. Development (1993) 2.66
Structural elements involved in specific K+ channel functions. Annu Rev Physiol (1992) 2.62
Two mutations of synaptic transmission in Drosophila. Proc R Soc Lond B Biol Sci (1977) 2.60
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci (2000) 2.57
Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev (1999) 2.56
Comparison of the autoSCAN-W/A rapid bacterial identification system and the Vitek AutoMicrobic system for identification of gram-negative bacilli. J Clin Microbiol (1991) 2.51
Cloning of a probable potassium channel gene from mouse brain. Nature (1988) 2.49
A superfamily of ion channels. Nature (1990) 2.49
Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature (1988) 2.47
Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates. J Biol Chem (1966) 2.45