Published in J Biol Chem on March 07, 2012
Intracellular BK(Ca) (iBK(Ca)) channels. J Physiol (2012) 1.05
BK channel activators and their therapeutic perspectives. Front Physiol (2014) 1.03
The physiology of protein S-acylation. Physiol Rev (2015) 1.03
Fat chance! Getting a grip on a slippery modification. ACS Chem Biol (2012) 0.98
ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Elife (2015) 0.96
Recurrent HERV-H-mediated 3q13.2-q13.31 deletions cause a syndrome of hypotonia and motor, language, and cognitive delays. Hum Mutat (2013) 0.94
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43. J Biol Chem (2013) 0.93
Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem (2013) 0.86
2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activities. PLoS One (2013) 0.84
Bisphenol A activates BK channels through effects on α and β1 subunits. Channels (Austin) (2014) 0.83
Regulation of large conductance calcium- and voltage-activated potassium (BK) channels by S-palmitoylation. Biochem Soc Trans (2013) 0.82
Ion channel regulation by protein S-acylation. J Gen Physiol (2014) 0.82
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2). J Biol Chem (2014) 0.81
Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics (2013) 0.79
A systematic analysis of protein palmitoylation in Caenorhabditis elegans. BMC Genomics (2014) 0.79
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii. J Biol Chem (2013) 0.79
Palmitoylation of plakophilin is required for desmosome assembly. J Cell Sci (2014) 0.78
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol (2016) 0.78
Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery (2014) 0.78
ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation. Mol Cell Biol (2016) 0.76
S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels. Front Physiol (2014) 0.76
Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizures. PLoS One (2015) 0.76
miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Blood (2015) 0.76
Fine-mapping and genetic analysis of the loci affecting hepatic iron overload in mice. PLoS One (2013) 0.76
S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment. Biochem J (2014) 0.76
Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease. Semin Liver Dis (2015) 0.75
A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery. Scand J Gastroenterol (2016) 0.75
PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females. Ethn Dis (2016) 0.75
Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. PLoS One (2016) 0.75
Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proc Natl Acad Sci U S A (2017) 0.75
Correlated duplications and losses in the evolution of palmitoylation writer and eraser families. BMC Evol Biol (2017) 0.75
Post-translational palmitoylation controls the voltage gating and lipid raft association of CALHM1 channel. J Physiol (2017) 0.75
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Global analysis of protein palmitoylation in yeast. Cell (2006) 4.43
Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
Role of ER export signals in controlling surface potassium channel numbers. Science (2001) 2.93
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
Protein palmitoylation in neuronal development and synaptic plasticity. Nat Rev Neurosci (2010) 2.66
Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta (2006) 2.49
Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res (2006) 2.45
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36
DHHC palmitoyl transferases: substrate interactions and (patho)physiology. Trends Biochem Sci (2011) 2.28
Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron (2005) 2.16
A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron (2009) 1.96
Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron (2009) 1.81
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Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. FASEB J (2009) 1.55
Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45
Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Proc Natl Acad Sci U S A (2008) 1.41
Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo. J Biol Chem (2002) 1.32
Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A. Structure (2000) 1.32
Mutational analysis of Saccharomyces cerevisiae Erf2 reveals a two-step reaction mechanism for protein palmitoylation by DHHC enzymes. J Biol Chem (2010) 1.31
Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. J Biol Chem (2010) 1.26
Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. Mol Cell Neurosci (2004) 1.25
Ion channel regulation by protein palmitoylation. J Biol Chem (2011) 1.25
Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One (2010) 1.18
Protein acyl thioesterases (Review). Mol Membr Biol (2008) 1.15
Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels. J Biol Chem (2010) 1.04
Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. J Biol Chem (2010) 0.98
Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. Biochim Biophys Acta (2009) 0.94
NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. J Biol Chem (2004) 0.89
Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem (2010) 0.87
Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. J Lipid Res (2011) 0.87
Altered gene expression of NIDD in dorsal root ganglia and spinal cord of rats with neuropathic or inflammatory pain. J Mol Histol (2007) 0.79
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A (2006) 3.13
Functional and spatial segregation of secretory vesicle pools according to vesicle age. Nature (2003) 2.55
Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity. Am J Physiol Cell Physiol (2007) 1.99
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation (2005) 1.80
Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem (2005) 1.78
Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A (2004) 1.67
Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells. Diabetes (2009) 1.58
Ca2+ -activated K+ channels of the BK-type in the mouse brain. Histochem Cell Biol (2005) 1.46
Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (2004) 1.45
Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Proc Natl Acad Sci U S A (2008) 1.41
Distal colonic K(+) secretion occurs via BK channels. J Am Soc Nephrol (2006) 1.35
A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J (2006) 1.31
Dual role of protein kinase C on BK channel regulation. Proc Natl Acad Sci U S A (2010) 1.29
Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion. J Physiol (2008) 1.24
Immunolocalization of BK channels in hippocampal pyramidal neurons. Eur J Neurosci (2006) 1.23
Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat. Eur J Neurosci (2006) 1.21
Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. Hum Mol Genet (2009) 1.21
A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc Natl Acad Sci U S A (2005) 1.15
The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Hum Mol Genet (2006) 1.14
Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice. Pflugers Arch (2010) 1.13
Interacting effects of N-terminal variation and strex exon splicing on slo potassium channel regulation by calcium, phosphorylation, and oxidation. J Biol Chem (2002) 1.12
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. J Neurosci (2008) 1.10
The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neurosci (2006) 1.10
Hierarchal type III secretion of translocators and effectors from Escherichia coli O157:H7 requires the carboxy terminus of SepL that binds to Tir. Mol Microbiol (2008) 1.10
Ionizing radiation, ion transports, and radioresistance of cancer cells. Front Physiol (2013) 1.09
Blunted IgE-mediated activation of mast cells in mice lacking the Ca2+-activated K+ channel KCa3.1. J Immunol (2008) 1.09
Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons. J Physiol (2003) 1.08
Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A (2010) 1.07
BK channels in innate immune functions of neutrophils and macrophages. Blood (2008) 1.07
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB J (2006) 1.07
Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS. BMC Dev Biol (2006) 1.07
Ca(v)1.3 and BK channels for timing and regulating cell firing. Mol Neurobiol (2010) 1.06
A novel isoform of SK2 assembles with other SK subunits in mouse brain. J Biol Chem (2005) 1.06
The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents. Exp Physiol (2007) 1.04
Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels. J Biol Chem (2010) 1.04
Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J (2008) 1.04
Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains. J Comp Neurol (2009) 1.02
M2 muscarinic receptors induce airway smooth muscle activation via a dual, Gbetagamma-mediated inhibition of large conductance Ca2+-activated K+ channel activity. J Biol Chem (2008) 1.01
Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channels. J Biol Chem (2002) 1.01
TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels. J Neurochem (2008) 1.00
Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels. Radiother Oncol (2011) 1.00
Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory. PLoS One (2013) 0.99
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med (2012) 0.99
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy. Brain Res (2008) 0.99
Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. J Biol Chem (2010) 0.98
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett (2002) 0.98
Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels. J Physiol (2010) 0.97
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci U S A (2004) 0.95
Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice. Am J Physiol Endocrinol Metab (2008) 0.95
Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. J Biol Chem (2011) 0.94
Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C. J Biol Chem (2012) 0.92
Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminals. J Neurochem (2010) 0.92
A high-capacity membrane potential FRET-based assay for NaV1.8 channels. Assay Drug Dev Technol (2006) 0.92
CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells. J Leukoc Biol (2007) 0.90
Neuronal Ca2+-activated K+ channels limit brain infarction and promote survival. PLoS One (2010) 0.90
Protease and pro-inflammatory cytokine concentrations are elevated in chronic compared to acute wounds and can be modulated by collagen type I in vitro. Arch Dermatol Res (2009) 0.90
Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Hum Mol Genet (2008) 0.90
An electrostatic switch controls palmitoylation of the large conductance voltage- and calcium-activated potassium (BK) channel. J Biol Chem (2011) 0.90
Surface expression, single-channel analysis and membrane topology of recombinant Chlamydia trachomatis Major Outer Membrane Protein. BMC Microbiol (2005) 0.89
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci (2013) 0.89
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med (2009) 0.89
The hemocyanin from a living fossil, the cephalopod Nautilus pompilius: protein structure, gene organization, and evolution. J Mol Evol (2006) 0.88
Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene. Mol Neurodegener (2007) 0.88
Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci (2009) 0.88
Association of phospholamban with a cGMP kinase signaling complex. Biochem Biophys Res Commun (2003) 0.87
Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem (2010) 0.87
Hypothalamic-pituitary-adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels. Endocrinology (2007) 0.87
BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo. PLoS One (2009) 0.86
Reversible tyrosine protein phosphorylation regulates large conductance voltage- and calcium-activated potassium channels via cortactin. J Biol Chem (2007) 0.86
Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem (2013) 0.86