Published in Science on March 02, 2001
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc Natl Acad Sci U S A (2006) 4.14
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p. EMBO J (2006) 2.52
Translation of the phosphoinositide code by PI effectors. Nat Chem Biol (2010) 1.86
Pleckstrin homology (PH) domains and phosphoinositides. Biochem Soc Symp (2007) 1.74
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol (2008) 1.57
Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch. Proc Natl Acad Sci U S A (2005) 1.47
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J (2004) 1.43
The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. Proc Natl Acad Sci U S A (2006) 1.39
Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta (2006) 1.37
The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J (2001) 1.31
Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting. J Mol Biol (2008) 1.31
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2006) 1.30
The role of hydrophobic interactions in positioning of peripheral proteins in membranes. BMC Struct Biol (2007) 1.20
Molecular mechanism of membrane docking by the Vam7p PX domain. J Biol Chem (2006) 1.12
A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. PLoS Genet (2013) 1.12
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis. Elife (2014) 1.11
Structural insight into histone recognition by the ING PHD fingers. Curr Drug Targets (2009) 1.11
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07
Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. J Am Chem Soc (2006) 1.05
Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res (2007) 1.02
Membrane insertion of the FYVE domain is modulated by pH. Proteins (2009) 1.01
Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. Biochem J (2005) 0.98
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. J Clin Invest (2014) 0.96
Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation. Mol Cell Biol (2006) 0.94
Investigation of the binding geometry of a peripheral membrane protein. Biochemistry (2005) 0.90
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
FYVE zinc-finger proteins in the plant model Arabidopsis thaliana: identification of PtdIns3P-binding residues by comparison of classic and variant FYVE domains. Biochem J (2001) 0.88
PtdIns5P: news and views of its appearance, disappearance and deeds. Arch Biochem Biophys (2013) 0.86
Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi. Mol Microbiol (2010) 0.86
Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate. Org Lett (2006) 0.86
Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation. Oncotarget (2016) 0.86
Lipid interaction networks of peripheral membrane proteins revealed by data-driven micelle docking. Biophys J (2007) 0.85
PIN-G--a novel reporter for imaging and defining the effects of trafficking signals in membrane proteins. BMC Biotechnol (2006) 0.83
Phosphoinositides differentially regulate protrudin localization through the FYVE domain. J Biol Chem (2012) 0.82
Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy. PLoS One (2014) 0.81
NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer. J Biol Chem (2012) 0.81
A high-resolution solution structure of a trypanosomatid FYVE domain. Protein Sci (2007) 0.81
Molecular analysis of protein-phosphoinositide interactions. Curr Top Microbiol Immunol (2012) 0.80
The phospholipid code: a key component of dying cell recognition, tumor progression and host-microbe interactions. Cell Death Differ (2015) 0.80
Identification and structural characterization of FYVE domain-containing proteins of Arabidopsis thaliana. BMC Plant Biol (2010) 0.78
Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure (2014) 0.78
Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics. Structure (2016) 0.78
Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature (1996) 4.49
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol (2001) 3.14
Location, location, location: membrane targeting directed by PX domains. Science (2001) 2.09
Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell (1999) 1.76
Molecular mechanism of NPF recognition by EH domains. Nat Struct Biol (2000) 1.66
Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. Science (1998) 1.64
Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem (2001) 1.13
The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct. Structure (1995) 1.04
Cloning, expression, and characterization of a DNA binding domain of gpNu1, a phage lambda DNA packaging protein. Biochemistry (1999) 1.02
Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites. Biochemistry (2000) 0.83
The plot thickens: how thrombin modulates blood clotting. Nat Struct Biol (2000) 0.78
Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain. J Biomol NMR (2000) 0.76
Sequence-specific 1H, 15N and 13C resonance assignments for the third EH domain of Eps15. J Biomol NMR (2000) 0.75
Assignment of the 1H, 13C, and 15N resonances of the DNA binding domain of gpNu1, a genome packaging protein from bacteriophage lambda. J Biomol NMR (2000) 0.75
Purification and spectroscopic characterization of a recombinant amino-terminal polypeptide fragment of mouse epithelial cadherin. FEBS Lett (1994) 0.75