Published in Biochim Biophys Acta on April 07, 2006
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Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria. J Biol Chem (2010) 0.82
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FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba. PLoS One (2010) 0.79
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Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell (1999) 4.51
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell (1998) 4.51
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell (1998) 4.01
FYVE fingers bind PtdIns(3)P. Nature (1998) 3.91
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Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol (2000) 2.97
Hrs recruits clathrin to early endosomes. EMBO J (2001) 2.82
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell (1999) 2.76
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Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2000) 2.59
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A functional PtdIns(3)P-binding motif. Nature (1998) 2.38
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr Biol (1996) 2.36
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol (2002) 2.34
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol (2001) 2.33
The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J Biol Chem (2000) 2.28
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev (1999) 2.26
Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol (1999) 2.15
Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol (1998) 2.15
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem (1997) 2.03
Multivalent endosome targeting by homodimeric EEA1. Mol Cell (2001) 2.03
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Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell (1999) 1.92
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PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem (1999) 1.79
Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell (1999) 1.76
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Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell (2000) 1.59
Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues. J Biol Chem (2000) 1.58
Structural mechanism of endosome docking by the FYVE domain. Science (2001) 1.56
The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Genes Cells (2002) 1.53
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci (2001) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
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The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells. J Biol Chem (2004) 1.39
Multivalent mechanism of membrane insertion by the FYVE domain. J Biol Chem (2003) 1.38
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol (2000) 1.37
A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci U S A (2001) 1.35
Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate. Semin Cell Dev Biol (2001) 1.34
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Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry (2001) 1.24
The molecular basis of the differential subcellular localization of FYVE domains. J Biol Chem (2004) 1.23
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. Mol Cell Biol (2004) 1.20
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. J Cell Sci (2005) 1.19
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Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. J Biol Chem (2002) 1.13
Computer modeling of the membrane interaction of FYVE domains. J Mol Biol (2003) 1.12
Endofin, an endosomal FYVE domain protein. J Biol Chem (2001) 1.11
Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem J (2001) 1.09
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A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor. Exp Cell Res (2004) 1.07
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Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J Biol Chem (1999) 0.98
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Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1. J Biol Chem (1998) 0.91
FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes. J Biol Chem (2001) 0.91
Investigation of the binding geometry of a peripheral membrane protein. Biochemistry (2005) 0.90
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