Published in Science on March 16, 2001
A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26
Mitochondrial quality control: a matter of life and death for neurons. EMBO J (2012) 1.83
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
Signaling the mitochondrial unfolded protein response. Biochim Biophys Acta (2012) 1.61
Mitohormesis. Cell Metab (2014) 1.57
Quality control of mitochondrial proteostasis. Cold Spring Harb Perspect Biol (2011) 1.55
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proc Natl Acad Sci U S A (2013) 1.54
Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ (2010) 1.53
Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol (2013) 1.42
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci (2010) 1.29
Phylogenetic analysis of fungal ABC transporters. BMC Genomics (2010) 1.22
Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion (2013) 1.17
Cardioprotective role of the mitochondrial ATP-binding cassette protein 1. Circ Res (2005) 1.17
Mitochondrial protein synthesis, import, and assembly. Genetics (2012) 1.17
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Biochim Biophys Acta (2014) 1.12
Gimap3 regulates tissue-specific mitochondrial DNA segregation. PLoS Genet (2010) 1.08
Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc Natl Acad Sci U S A (2012) 1.05
Erythropoiesis and iron sulfur cluster biogenesis. Adv Hematol (2010) 0.99
The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ (2012) 0.99
Intracellular peptide transporters in human--compartmentalization of the "peptidome". Pflugers Arch (2006) 0.98
Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria. EMBO J (2011) 0.94
Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases? Cell Signal (2011) 0.92
Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Proc Natl Acad Sci U S A (2013) 0.90
Estrogen, mitochondria, and growth of cancer and non-cancer cells. J Carcinog (2005) 0.90
Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Dev Dyn (2010) 0.90
UPR(mt)-mediated cytoprotection and organismal aging. Biochim Biophys Acta (2015) 0.88
Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta (2012) 0.84
The inner-mitochondrial distribution of Oxa1 depends on the growth conditions and on the availability of substrates. Mol Biol Cell (2012) 0.81
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS. J Biol Chem (2015) 0.81
Gimap3: A foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics. Small GTPases (2011) 0.80
Dual targeting and retrograde translocation: regulators of plant nuclear gene expression can be sequestered by plastids. Int J Mol Sci (2012) 0.80
Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like. Mol Biol Cell (2009) 0.80
Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae. PLoS One (2013) 0.78
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxid Med Cell Longev (2016) 0.77
How do yeast sense mitochondrial dysfunction? Microb Cell (2016) 0.75
Diversity and evolution of ABC proteins in mycorrhiza-forming fungi. BMC Evol Biol (2015) 0.75
Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence. Biochem J (2016) 0.75
Genetic variation and expression changes associated with molybdate resistance from a glutathione producing wine strain of Saccharomyces cerevisiae. PLoS One (2017) 0.75
Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate. Nature (1991) 6.20
A novel cysteine-rich sequence motif. Cell (1991) 4.39
DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage. EMBO J (1993) 4.32
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem Sci (1994) 3.65
The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. Nucleic Acids Res (1992) 3.57
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J Cell Sci (2000) 3.50
The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. J Clin Invest (1972) 3.43
The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE. Proc Natl Acad Sci U S A (1994) 3.33
Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22
Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A (2000) 3.09
Genetic analysis of a class of polymyxin resistant partial revertants of stage O sporulation mutants of Bacillus subtilis: map of the chromosome region near the origin of replication. Mol Gen Genet (1979) 3.03
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc Natl Acad Sci U S A (2001) 2.86
A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature (1991) 2.84
DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J Mol Biol (1992) 2.82
The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell (1996) 2.80
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells. Nature (1989) 2.61
Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U S A (1993) 2.55
cDNA clones coding for the heavy chain of human HLA-DR antigen. Proc Natl Acad Sci U S A (1982) 2.51
Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem Sci (1994) 2.44
DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J Immunol (2000) 2.38
Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Mol Cell Biol (1999) 2.34
Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc Natl Acad Sci U S A (1989) 2.34
Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles. Rheumatology (Oxford) (2006) 2.31
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding. Nature (1993) 2.30
Second proteasome-related gene in the human MHC class II region. Nature (1991) 2.29
Dynamics of proteasome distribution in living cells. EMBO J (1997) 2.18
Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene. Nature (1982) 2.18
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. Science (1997) 2.18
The MHC haplotype project: a resource for HLA-linked association studies. Tissue Antigens (2002) 2.16
Structure, sequence and polymorphism in the HLA-D region. Immunol Rev (1985) 2.16
The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens (2004) 2.13
Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis. Proc Natl Acad Sci U S A (1987) 2.13
Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature (1992) 2.12
Folate-binding protein is a marker for ovarian cancer. Cancer Res (1991) 2.12
Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science (1994) 2.08
The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37. Ann Hum Genet (1987) 2.00
Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH. J Biol Chem (1999) 1.97
Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci U S A (1990) 1.93
A new human HLA class II-related locus, DM. Nature (1991) 1.91
Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types. Proc Natl Acad Sci U S A (1984) 1.90
A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq (1992) 1.85
Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes. Proc Natl Acad Sci U S A (1983) 1.85
Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Mol Microbiol (1999) 1.80
Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. EMBO J (1994) 1.80
Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes. Nucleic Acids Res (1985) 1.76
The complete nucleotide sequence of the I-E alpha d immune response gene. Nucleic Acids Res (1983) 1.75
Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface. Mol Cell (2000) 1.73
Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides. Proc Natl Acad Sci U S A (1993) 1.72
Map of the human MHC. Immunol Today (1993) 1.72
Genetics and molecular genetics of the MHC. Rev Immunogenet (1999) 1.69
Characterization of recombination in the HLA class II region. Am J Hum Genet (1997) 1.69
Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli. Mol Microbiol (1998) 1.68
Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease. Nature (1999) 1.62
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Tissue Antigens (2003) 1.60
Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J Pathol (2001) 1.58
Nomenclature for factors of the HLA system, 2004. Tissue Antigens (2005) 1.57
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading. Curr Biol (1997) 1.57
The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. EMBO J (1998) 1.56
Why drugs fail--a study on side effects in new chemical entities. Curr Pharm Des (2005) 1.54
Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules. J Immunol (1990) 1.53
Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi. Nature (1992) 1.50
Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma. Br J Cancer (1993) 1.49
The cluster of BTN genes in the extended major histocompatibility complex. Genomics (2001) 1.48
Kidney instant monitoring (K.IN.G): a new analyzer to monitor kidney function. Minerva Anestesiol (2010) 1.47
Yta10p is required for the ATP-dependent degradation of polypeptides in the inner membrane of mitochondria. FEBS Lett (1994) 1.46
Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J Exp Med (1995) 1.46
Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer. Br J Cancer (1993) 1.44
Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System. Clin Endocrinol (Oxf) (2007) 1.42
New cluster of ribosomal genes in Bacillus subtilis with regulatory role in sporulation. Nature (1978) 1.42
AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis. Biochem Soc Trans (2001) 1.42
Linkage map of two HLA-SB beta and two HLA-SB alpha-related genes: an intron in one of the SB beta genes contains a processed pseudogene. Cell (1984) 1.41
Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. J Immunol (2001) 1.41
An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains. Cancer Res (1992) 1.40
Acute muscular syndrome associated with administration of clofibrate. N Engl J Med (1968) 1.40
Hsp78, a Clp homologue within mitochondria, can substitute for chaperone functions of mt-hsp70. EMBO J (1995) 1.36
TAP deficiency syndrome. Clin Exp Immunol (2000) 1.35
Association between HLA-DM and HLA-DR in vivo. Immunity (1996) 1.34
Introduction of a human X-6 translocation chromosome into a mouse teratocarcinoma: investigation of control of HLA-A, B, C expression. Proc Natl Acad Sci U S A (1982) 1.33
A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. Nucleic Acids Res (1985) 1.30
Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1992) 1.30
The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. EMBO J (1987) 1.30
Isolation, characterization, and mapping of Bacillus subtilis 168 germination mutants. J Bacteriol (1975) 1.28
Divergent and convergent evolution of NK-cell receptors. Trends Immunol (2001) 1.28
Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics (1993) 1.27
Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC. J Mol Biol (1998) 1.27
The transporters associated with antigen presentation. Semin Cell Biol (1993) 1.27
Afferents to the flocculus of the cerebellum in the rhesus macaque as revealed by retrograde transport of horseradish peroxidase. J Comp Neurol (1985) 1.26
MHC-linked olfactory receptor loci exhibit polymorphism and contribute to extended HLA/OR-haplotypes. Genome Res (2000) 1.25
Mitochondrial Hsp78, a member of the Clp/Hsp100 family in Saccharomyces cerevisiae, cooperates with Hsp70 in protein refolding. FEBS Lett (2001) 1.23
SpoVM, a small protein essential to development in Bacillus subtilis, interacts with the ATP-dependent protease FtsH. J Bacteriol (1997) 1.22
Allele loss on chromosome 17q in sporadic ovarian cancer. Lancet (1991) 1.21
GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene (2007) 1.21
Evidence for the Translocation of a Chromosome Sement in Bacillus subtilis Strains Carrying the trpE26 Mutation. J Bacteriol (1975) 1.20
The human major histocompatability complex: lessons from the DNA sequence. Annu Rev Genomics Hum Genet (2000) 1.20
Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial function. FEBS Lett (1994) 1.20
Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr Biol (1994) 1.18
Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients. J Exp Med (1988) 1.18
Sequence organisation of the class II region of the human MHC. Immunol Rev (1999) 1.18