Mitohormesis.

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab (2015) 1.89

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature (2015) 1.52

Drug synergy drives conserved pathways to increase fission yeast lifespan. PLoS One (2015) 1.39

Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23

Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol (2015) 1.15

Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome. Cell Cycle (2015) 1.10

Mitochondrial division and fusion in metabolism. Curr Opin Cell Biol (2015) 1.03

Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol (2016) 1.01

Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Res (2014) 0.98

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Mol Cell (2015) 0.97

The role of mitochondrial DNA mutation on neurodegenerative diseases. Exp Mol Med (2015) 0.96

Mitochondrial quality control pathways as determinants of metabolic health. Bioessays (2015) 0.95

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Nat Cell Biol (2015) 0.90

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol (2016) 0.88

Mechanisms by which different functional states of mitochondria define yeast longevity. Int J Mol Sci (2015) 0.87

Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? Int J Mol Sci (2015) 0.87

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases. Front Pharmacol (2016) 0.86

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system. J Mol Cell Cardiol (2014) 0.86

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria. J Clin Biochem Nutr (2015) 0.84

Spatial reorganization of telomeres in long-lived quiescent cells. Genome Biol (2015) 0.84

The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious responses to oxidative stress in striated muscle. Front Physiol (2014) 0.84

Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms. Front Genet (2016) 0.84

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. Proc Natl Acad Sci U S A (2015) 0.83

Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury. J Bioenerg Biomembr (2014) 0.83

Mitochondria in lung disease. J Clin Invest (2016) 0.82

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun (2015) 0.82

Wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of Wolbachia-host interactions. Front Microbiol (2015) 0.82

Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies. Aging Dis (2016) 0.81

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One (2015) 0.81

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state. Oncotarget (2016) 0.81

From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase. Circ Res (2015) 0.81

Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget (2016) 0.80

The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases. Aging Dis (2016) 0.79

Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron (2017) 0.79

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis. Cell Death Differ (2015) 0.79

Mitochondrial Hormesis links nutrient restriction to improved metabolism in fat cell. Aging (Albany NY) (2015) 0.79

Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy. Cell Mol Life Sci (2014) 0.79

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy. Circ Res (2016) 0.79

Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions. Sci Rep (2017) 0.78

Role of Energy Metabolism in the Brown Fat Gene Program. Front Endocrinol (Lausanne) (2015) 0.78

Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria. J Biol Chem (2015) 0.78

The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment. Anal Cell Pathol (Amst) (2015) 0.78

The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase. Oxid Med Cell Longev (2016) 0.78

Formation of Mitochondrial Outer Membrane Derived Protrusions and Vesicles in Arabidopsis thaliana. PLoS One (2016) 0.78

The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neurons. Int J Mol Sci (2014) 0.77

Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers! Front Genet (2016) 0.77

L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis. Oxid Med Cell Longev (2015) 0.77

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med (2016) 0.77

Complex-I-ty in aging. J Bioenerg Biomembr (2014) 0.77

The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making. Chem Res Toxicol (2016) 0.77

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase. Redox Biol (2016) 0.77

Regulation of the H(+)-ATP synthase by IF1: a role in mitohormesis. Cell Mol Life Sci (2017) 0.77

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift. Mol Biol Cell (2015) 0.76

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Cell Rep (2016) 0.76

Hormetic effect of rotenone in primary human fibroblasts. Immun Ageing (2015) 0.76

Fragile lifespan expansion by dietary mitohormesis in C. elegans. Aging (Albany NY) (2016) 0.76

The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol (2016) 0.76

Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level. Front Physiol (2017) 0.75

Metabolic remodeling during the loss and acquisition of pluripotency. Development (2017) 0.75

The role of hydrogen sulfide in aging and age-related pathologies. Aging (Albany NY) (2016) 0.75

Resveratrol Inhibition of Cellular Respiration: New Paradigm for an Old Mechanism. Int J Mol Sci (2016) 0.75

Mitochondrial outer membrane forms bridge between two mitochondria in Arabidopsis thaliana. Plant Signal Behav (2016) 0.75

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep (2017) 0.75

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise. Curr Diab Rep (2017) 0.75

Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. PLoS One (2017) 0.75

Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light. Sci Rep (2016) 0.75

Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability. Islets (2016) 0.75

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J (2016) 0.75

Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep (2017) 0.75

Review: can diet influence the selective advantage of mitochondrial DNA haplotypes? Biosci Rep (2015) 0.75

Being right on Q: shaping eukaryotic evolution. Biochem J (2016) 0.75

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies. Sci Rep (2015) 0.75

Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell (2016) 0.75

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses. Mol Cell Biol (2016) 0.75

Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity. Curr Genet (2017) 0.75

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans. Redox Biol (2017) 0.75

The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system. Cell Death Dis (2017) 0.75

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance. Cell Rep (2017) 0.75

Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxid Med Cell Longev (2017) 0.75

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41

Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18

Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature (2006) 10.07

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J (2007) 9.65

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell (2005) 9.16

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J (2000) 7.77

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature (2011) 7.44

Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA (2005) 7.35

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature (2011) 6.48

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26

Defining hormesis. Hum Exp Toxicol (2002) 6.05

The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell (2011) 6.05

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell (2011) 5.91

Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21

Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med (2011) 4.81

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell (2001) 4.49

Lysosomal membrane permeabilization in cell death. Oncogene (2008) 4.40

Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16

A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95

Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science (2012) 3.86

Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol (2013) 3.73

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26

A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol (2010) 3.24

Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol (2012) 3.18

Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab (2011) 3.13

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol (2011) 3.05

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr (2008) 3.01

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One (2010) 2.81

The human mitochondrial transcriptome. Cell (2011) 2.70

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68

Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68

The mitochondrial genotype can influence nuclear gene expression in yeast. Science (1987) 2.62

Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J (1999) 2.62

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell (2007) 2.61

Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol (2010) 2.55

Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell (2001) 2.55

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics (1999) 2.50

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev (2005) 2.39

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A (2001) 2.39

Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab (2012) 2.34

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21

Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol (2009) 2.19

Bacterial social engagements. Trends Cell Biol (2004) 2.17

Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol (2000) 2.13

Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One (2013) 2.10

Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab (2013) 2.03

Coordinate induction of energy gene expression in tissues of mitochondrial disease patients. J Biol Chem (1999) 2.02

Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell (2000) 1.98

Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol (2003) 1.69

Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. PLoS Genet (2012) 1.67

Regulation of organismal proteostasis by transcellular chaperone signaling. Cell (2013) 1.66

Signal transduction by mitochondrial oxidants. J Biol Chem (2011) 1.65

Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription. Sci Signal (2012) 1.56

Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science (2001) 1.53

Xenohormesis: sensing the chemical cues of other species. Cell (2008) 1.50

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene (2010) 1.41

Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab (2012) 1.38

Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice. J Biol Chem (2009) 1.38

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet (2012) 1.28

RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J (2001) 1.27

Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem (1997) 1.25

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23

Rtg2 protein links metabolism and genome stability in yeast longevity. Genetics (2004) 1.22

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest (2004) 1.21

Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast. J Biol Chem (1995) 1.21

A systems approach for decoding mitochondrial retrograde signaling pathways. Sci Signal (2013) 1.16

Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab (2013) 1.13

Exploring the therapeutic space around NAD+. J Cell Biol (2012) 1.09

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell (2013) 1.04

NAD and ADP-ribose metabolism in mitochondria. FEBS J (2013) 1.01

Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol (2013) 1.01

A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr Biol (2013) 0.99

Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. Cell Metab (2012) 0.96

Resistance to type 2 diabetes mellitus: a matter of hormesis? Nat Rev Endocrinol (2011) 0.94

Why translation counts for mitochondria - retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation. J Cell Sci (2013) 0.81

The Mitochondrial Basis of Aging. Mol Cell (2016) 1.02