Published in J Mol Biol on March 23, 2001
Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR. Structure (2010) 1.40
Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. Am J Hum Genet (2006) 1.24
Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages. Genome Biol (2007) 1.20
Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. J Biol Chem (2009) 1.17
Confidence intervals for fitting of atomic models into low-resolution densities. Acta Crystallogr D Biol Crystallogr (2009) 1.13
Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochem J (2002) 1.08
Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children. Am J Clin Nutr (2009) 1.03
The structure and allosteric regulation of mammalian glutamate dehydrogenase. Arch Biochem Biophys (2011) 1.03
Structure-based predictive models for allosteric hot spots. PLoS Comput Biol (2009) 0.98
Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site. J Biol Chem (2011) 0.98
Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). J Biol Chem (2009) 0.96
Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum). J Biol Chem (2010) 0.91
High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors. Biochemistry (2007) 0.90
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Mol Biol Cell (2012) 0.87
The structure and allosteric regulation of glutamate dehydrogenase. Neurochem Int (2010) 0.85
Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase. J Biol Chem (2011) 0.85
Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases. FEBS J (2013) 0.84
Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity? Neurochem Int (2011) 0.81
Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression. Neurochem Int (2011) 0.81
Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. Mol Pharmacol (2016) 0.79
Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation. Protein Sci (2010) 0.78
A computational analysis of the three isoforms of glutamate dehydrogenase reveals structural features of the isoform EC 1.4.1.4 supporting a key role in ammonium assimilation by plants. Biol Direct (2006) 0.78
The D-Lactate Dehydrogenase from Sporolactobacillus inulinus Also Possessing Reversible Deamination Activity. PLoS One (2015) 0.77
Measuring the effect of ligand binding on the interface stability of multimeric proteins using dynamic light scattering. Anal Biochem (2010) 0.77
Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases. Sci Rep (2015) 0.76
Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications. Biology (Basel) (2016) 0.75
A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J (2011) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of NADP-dependent glutamate dehydrogenase from Aspergillus niger. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Computational design of glutamate dehydrogenase in Bacillus subtilis natto. J Mol Model (2013) 0.75
Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion. Cell (1981) 8.69
Single-molecule microscopy on model membranes reveals anomalous diffusion. Biophys J (1997) 5.04
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J Exp Med (1998) 3.32
Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med (1998) 2.57
Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol (1998) 2.52
Evidence for high affinity binding-protein dependent transport systems in gram-positive bacteria and in Mycoplasma. EMBO J (1988) 2.47
Protein-RNA interactions in an icosahedral virus at 3.0 A resolution. Science (1989) 2.45
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A (2000) 2.43
The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer. Clin Pharmacol Ther (2013) 2.40
Autofluorescent proteins in single-molecule research: applications to live cell imaging microscopy. Biophys J (2001) 2.35
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene (1999) 2.34
Familial hyperinsulinism with apparent autosomal dominant inheritance: clinical and genetic differences from the autosomal recessive variant. J Pediatr (1998) 2.33
Structure of an insect virus at 3.0 A resolution. Proteins (1987) 2.23
The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther (2009) 2.19
A syndrome of congenital hyperinsulinism and hyperammonemia. J Pediatr (1997) 2.15
Free Brownian motion of individual lipid molecules in biomembranes. Biophys J (1999) 2.06
De novo rearrangements found in 2% of index patients with spinal muscular atrophy: mutational mechanisms, parental origin, mutation rate, and implications for genetic counseling. Am J Hum Genet (1997) 2.05
Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci U S A (2000) 2.03
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease. Neurology (1998) 1.96
Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatr Res (1983) 1.91
A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism. Diabetes (1997) 1.86
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene (2000) 1.82
The initiator tRNA genes of Drosophila melanogaster: evidence for a tRNA pseudogene. Nucleic Acids Res (1981) 1.82
A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells. EMBO J (1988) 1.80
The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci (2001) 1.80
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews. Hum Mol Genet (1996) 1.76
Genetic deficiency of medium-chain acyl coenzyme A dehydrogenase: studies in cultured skin fibroblasts and peripheral mononuclear leukocytes. Pediatr Res (1985) 1.75
Single-molecule imaging of l-type Ca(2+) channels in live cells. Biophys J (2001) 1.72
Direct observation of ligand colocalization on individual receptor molecules. Biophys J (1998) 1.71
The causes of neonatal hypoglycemia. N Engl J Med (1999) 1.68
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J (2000) 1.67
High-resolution soft X-ray beamline ADRESS at the Swiss Light Source for resonant inelastic X-ray scattering and angle-resolved photoelectron spectroscopies. J Synchrotron Radiat (2010) 1.66
Acute fatty liver of pregnancy, hemolysis, elevated liver enzymes, and low platelets syndrome, and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Am J Gastroenterol (1996) 1.66
Short- and long-term use of octreotide in the treatment of congenital hyperinsulinism. J Pediatr (1993) 1.65
Analysis of a repetitive DNA family from Arabidopsis arenosa and relationships between Arabidopsis species. Plant Mol Biol (1995) 1.61
Dyspepsia and irritable bowel syndrome in China: a population-based endoscopy study of prevalence and impact. Aliment Pharmacol Ther (2010) 1.59
Insulin-like growth factor binding protein-1 levels in the diagnosis of hypoglycemia caused by hyperinsulinism. J Pediatr (1997) 1.58
Variability of motor potentials evoked by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol (1993) 1.58
Long-chain acyl coenzyme A dehydrogenase deficiency: an inherited cause of nonketotic hypoglycemia. Pediatr Res (1985) 1.56
Gastrointestinal bleeding after acute ischemic stroke. Neurology (2008) 1.56
Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother (1995) 1.52
Linkage-disequilibrium mapping without genotyping. Nat Genet (1998) 1.52
Eosinophilic oesophagitis in patients presenting with dysphagia--a prospective analysis. Aliment Pharmacol Ther (2008) 1.49
Genotype and phenotype correlations in 417 children with congenital hyperinsulinism. J Clin Endocrinol Metab (2012) 1.49
Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N Engl J Med (1988) 1.49
Dual regulation of insulin-like growth factor binding protein-1 levels by insulin and cortisol during fasting. J Clin Endocrinol Metab (1998) 1.48
Measurement of the depth of maximum of extensive air showers above 10{18} eV. Phys Rev Lett (2010) 1.48
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain. AJNR Am J Neuroradiol (2011) 1.47
The refined crystal structure of cowpea mosaic virus at 2.8 A resolution. Virology (1999) 1.46
Accuracy of anorectal manometry in patients with fecal incontinence. Digestion (2012) 1.46
OpenStructure: an integrated software framework for computational structural biology. Acta Crystallogr D Biol Crystallogr (2013) 1.46
Decreased oxygenation and hyperlipemia during intravenous fat infusions in premature infants. Pediatrics (1980) 1.45
Sudden neonatal death in carnitine transporter deficiency. J Pediatr (1997) 1.43
Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. J Pediatr (2001) 1.42
Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase. J Clin Endocrinol Metab (2001) 1.42
spFRET using alternating excitation and FCS reveals progressive DNA unwrapping in nucleosomes. Biophys J (2009) 1.42
Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9. Biochem Biophys Res Commun (1994) 1.42
Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A. J Thromb Haemost (2007) 1.41
Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol (1999) 1.41
Acute fatty liver of pregnancy and long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Hepatology (1994) 1.41
Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab Invest (1998) 1.40
Meta-analysis of standard, restrictive and supplemental fluid administration in colorectal surgery. Br J Surg (2009) 1.39
The extracellular remodeling of free-soft-tissue autografts and allografts for reconstruction of the anterior cruciate ligament: a comparison study in a sheep model. Knee Surg Sports Traumatol Arthrosc (2008) 1.39
In vivo plasma membrane organization: results of biophysical approaches. Biochim Biophys Acta (2004) 1.39
Massive hepatomegaly, steatosis, and secondary plasma carnitine deficiency in an infant with cystic fibrosis. Pediatrics (1989) 1.39
Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2. Oncogene (1996) 1.39
Single-molecule anisotropy imaging. Biophys J (1999) 1.37
Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron. Mol Cell Biol (1995) 1.37
Hyperinsulinism in infancy: diagnosis by demonstration of abnormal response to fasting hypoglycemia. Pediatrics (1976) 1.35
Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism. J Pediatr (1980) 1.34
Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. Am J Physiol Endocrinol Metab (2006) 1.33
Mitochondrial carnitine-acylcarnitine translocase deficiency presenting as sudden neonatal death. J Pediatr (1997) 1.32
Differential gene expression between normal and tumor-derived ovarian epithelial cells. Cancer Res (2000) 1.32
Familial and sporadic hyperinsulinism: histopathologic findings and segregation analysis support a single autosomal recessive disorder. J Pediatr (1991) 1.30
Effects of bisphenol A on energy balance and accumulation in brown adipose tissue in rats. Chemosphere (2001) 1.30
Single-pair FRET microscopy reveals mononucleosome dynamics. J Fluoresc (2007) 1.29
Particle image correlation spectroscopy (PICS): retrieving nanometer-scale correlations from high-density single-molecule position data. Biophys J (2006) 1.26
The chromosomal distributions of Ty1-copia group retrotransposable elements in higher plants and their implications for genome evolution. Genetica (1997) 1.26
European Cytogeneticists Association Register of Unbalanced Chromosome Aberrations (ECARUCA); an online database for rare chromosome abnormalities. Eur J Med Genet (2005) 1.26
Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour. Br J Cancer (2003) 1.26
Upper gastrointestinal bleeding: predictors of outcome. Surgery (1986) 1.25
Soybean genomic survey: BAC-end sequences near RFLP and SSR markers. Genome (2001) 1.24
Prediction uncertainty of environmental change effects on temperate European biodiversity. Ecol Lett (2007) 1.23
The large-scale organization of the centromeric region in Beta species. Genome Res (2001) 1.21
Use of complementary and alternative medicine in patients suffering from primary headache disorders. Cephalalgia (2009) 1.21
Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts. N Engl J Med (1988) 1.19
Nuclear factor-kappaB inhibitor peptide inhibits spontaneous and interleukin-1beta-induced sleep. Am J Physiol Regul Integr Comp Physiol (2000) 1.19
Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase. Biochem J (2001) 1.19
Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus-contaminating recombinant adenovirus stocks. J Virol Methods (1996) 1.19
Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. Nat Genet (1994) 1.18
Spatiotemporal stability of a femtosecond hard-x-ray undulator source studied by control of coherent optical phonons. Phys Rev Lett (2007) 1.16
Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome. J Clin Invest (1988) 1.16
Determination of the equilibrium constants of associating protein systems. 3. Evaluation of the weight fraction of monomer from the weight-average partition coefficient (application to bovine liver glutamate dehydrogenase). Biochemistry (1969) 1.15
Disorders of glutamate metabolism. Ment Retard Dev Disabil Res Rev (2001) 1.15