Multistep assembly of the protein import channel of the mitochondrial outer membrane.

PubWeight™: 2.46‹?› | Rank: Top 2%

🔗 View Article (PMID 11276259)

Published in Nat Struct Biol on April 01, 2001

Authors

K Model1, C Meisinger, T Prinz, N Wiedemann, K N Truscott, N Pfanner, M T Ryan

Author Affiliations

1: Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Strasse 7, D-79104 Freiburg Germany.

Articles citing this

Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46

The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. J Cell Biol (2003) 3.11

Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep (2008) 2.19

Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins. EMBO Rep (2003) 1.97

Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet (2009) 1.90

Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I. Mol Cell Biol (2007) 1.82

Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. Mol Biol Cell (2002) 1.76

Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J Cell Biol (2004) 1.66

Biogenesis of beta-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence. Cell Mol Life Sci (2009) 1.62

Characterization of the translocon of the outer envelope of chloroplasts. J Cell Biol (2003) 1.62

The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J (2007) 1.58

Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell (2005) 1.55

Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. EMBO Rep (2004) 1.41

Signals in bacterial beta-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria. Proc Natl Acad Sci U S A (2009) 1.40

The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins. J Cell Biol (2006) 1.35

Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol (2007) 1.22

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell (2007) 1.22

The peripheral membrane subunits of the SAM complex function codependently in mitochondrial outer membrane biogenesis. Mol Biol Cell (2007) 1.20

Mitochondrial protein synthesis, import, and assembly. Genetics (2012) 1.17

Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss). BMC Genomics (2007) 1.11

VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways. EMBO J (2002) 1.06

Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40. EMBO Rep (2010) 1.03

Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep (2005) 1.01

Mitochondrial protein import and the genesis of steroidogenic mitochondria. Mol Cell Endocrinol (2010) 1.00

Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa. Mol Biol Cell (2010) 0.97

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell (2012) 0.96

Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell (2008) 0.95

Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40. J Biol Chem (2010) 0.92

Functions of the small proteins in the TOM complex of Neurospora crasssa. Mol Biol Cell (2005) 0.91

Mechanisms of protein sorting in mitochondria. Cold Spring Harb Perspect Biol (2012) 0.91

Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nat Commun (2015) 0.86

Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol Biol Cell (2011) 0.86

Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Mol Cell Biol (2009) 0.86

Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex. Mol Biol Cell (2010) 0.84

Mitochondria can recognize and assemble fragments of a beta-barrel structure. Mol Biol Cell (2011) 0.84

Alternative splicing gives rise to different isoforms of the Neurospora crassa Tob55 protein that vary in their ability to insert beta-barrel proteins into the outer mitochondrial membrane. Genetics (2007) 0.84

Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo. Curr Genet (2003) 0.84

The Neurospora crassa TOB complex: analysis of the topology and function of Tob38 and Tob37. PLoS One (2011) 0.84

A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways. Proc Natl Acad Sci U S A (2012) 0.83

Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import. Mol Biol Cell (2012) 0.83

Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport. Sci Rep (2013) 0.83

Dynamics of the preprotein translocation channel of the outer membrane of mitochondria. Biophys J (2008) 0.82

Barreling through the outer membrane. Nat Struct Biol (2001) 0.82

From evolution to pathogenesis: the link between β-barrel assembly machineries in the outer membrane of mitochondria and gram-negative bacteria. Int J Mol Sci (2012) 0.81

Evolutionary conservation in biogenesis of β-barrel proteins allows mitochondria to assemble a functional bacterial trimeric autotransporter protein. J Biol Chem (2014) 0.80

Role of phosphatidylethanolamine in the biogenesis of mitochondrial outer membrane proteins. J Biol Chem (2013) 0.80

Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to β-barrel protein assembly and maintenance of mitochondrial morphology. PLoS One (2013) 0.80

Characterization of the targeting signal in mitochondrial β-barrel proteins. Nat Commun (2016) 0.78

Assembly of the β-Barrel Outer Membrane Proteins in Gram-Negative Bacteria, Mitochondria, and Chloroplasts. ISRN Mol Biol (2012) 0.77

The Tom40 assembly process probed using the attachment of different intramitochondrial sorting signals. Mol Biol Cell (2012) 0.76

Evidence supporting the 19 β-strand model for Tom40 from cysteine scanning and protease site accessibility studies. J Biol Chem (2014) 0.76

Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40. J Biol Chem (2015) 0.75

Bacterial tail anchors can target to the mitochondrial outer membrane. Biol Direct (2017) 0.75

Articles by these authors

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81

Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature (1998) 3.77

Mitochondrial protein import. Biochim Biophys Acta (1989) 3.66

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol (2001) 3.06

Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature (1997) 2.88

High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia (2003) 2.73

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61

Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell (1987) 2.61

Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms. J Biol Chem (1988) 2.43

Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ (2010) 2.34

Transport of F1-ATPase subunit beta into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett (1986) 2.33

The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J (1997) 2.28

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28

Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem (2000) 2.26

Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J (1985) 2.19

MOM19, an import receptor for mitochondrial precursor proteins. Cell (1989) 2.18

Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences. J Biol Chem (1991) 2.17

Assaying protein import into mitochondria. Methods Cell Biol (2001) 2.04

Distinct steps in the import of ADP/ATP carrier into mitochondria. J Biol Chem (1987) 2.02

A mitochondrial import receptor for the ADP/ATP carrier. Cell (1990) 1.95

How do polypeptides cross the mitochondrial membranes? Cell (1990) 1.91

The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell (1999) 1.91

Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (1990) 1.90

Incidence of Type 2 diabetes in the elderly German population and the effect of clinical and lifestyle risk factors: KORA S4/F4 cohort study. Diabet Med (2009) 1.82

Analysis of mitochondrial protein import using translocation intermediates and specific antibodies. Methods Cell Biol (1991) 1.81

The MONICA Augsburg surveys--basis for prospective cohort studies. Gesundheitswesen (2005) 1.76

Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol (1993) 1.73

Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol (1990) 1.72

Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J (2007) 1.68

The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell (1993) 1.67

Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem (1997) 1.66

Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J Cell Biol (2001) 1.65

Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep (2000) 1.64

[Quality of care and extent of complications in a population-based sample of patients with type 2 diabetes mellitus. The KORA Survey 2000]. Dtsch Med Wochenschr (2006) 1.64

Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett (1990) 1.60

The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J (2001) 1.60

Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature (1992) 1.56

Regional differences in the prevalence of known Type 2 diabetes mellitus in 45-74 years old individuals: results from six population-based studies in Germany (DIAB-CORE Consortium). Diabet Med (2012) 1.56

Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature (1999) 1.56

Partner proteins determine multiple functions of Hsp70. Trends Cell Biol (1995) 1.55

What is the real hospital mortality from acute myocardial infarction? Epidemiological vs clinical view. Eur Heart J (2002) 1.54

Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53

Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem (1999) 1.52

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site. J Cell Biol (1988) 1.52

Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J (1996) 1.51

Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem (1999) 1.50

Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations. Anal Biochem (2000) 1.48

Targeting of the master receptor MOM19 to mitochondria. Science (1991) 1.48

Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002. Diabetologia (2007) 1.45

The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol Cell Biol (1993) 1.43

Is primary aldosteronism associated with diabetes mellitus? Results of the German Conn's Registry. Horm Metab Res (2010) 1.42

Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. J Biol Chem (1994) 1.42

Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies. Horm Metab Res (2008) 1.41

The population-based acute myocardial infarction (AMI) registry of the MONICA/KORA study region of Augsburg. Gesundheitswesen (2005) 1.39

Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol Biol Cell (2000) 1.39

Mitochondrial protein import. Bypass of proteinaceous surface receptors can occur with low specificity and efficiency. J Biol Chem (1989) 1.36

Mutations of the mitochondrial ND1 gene as a cause of MELAS. J Med Genet (2004) 1.35

Insertion of MOM22 into the mitochondrial outer membrane strictly depends on surface receptors. FEBS Lett (1993) 1.35

Mechanisms of protein translocation into mitochondria. Biochim Biophys Acta (1999) 1.33

The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences. Mol Cell Biol (1997) 1.33

[Epidemiology of hypertension in Germany. Selected results of population-representative cross-sectional studies]. Dtsch Med Wochenschr (2006) 1.32

Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix. FEBS Lett (1990) 1.31

Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space. FEBS Lett (1991) 1.30

Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60. Mol Cell Biol (1995) 1.29

Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J (1996) 1.28

Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002. Diabetologia (2006) 1.28

Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes. Mol Cell Biol (1994) 1.27

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo. J Cell Biol (1991) 1.26

Sex differences in the associations of socioeconomic status with undiagnosed diabetes mellitus and impaired glucose tolerance in the elderly population: the KORA Survey 2000. Eur J Public Health (2005) 1.26

Mitochondrial porin of Neurospora crassa: cDNA cloning, in vitro expression and import into mitochondria. EMBO J (1987) 1.25

Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell (1999) 1.25

Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis. Biol Chem (1997) 1.23

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett (1993) 1.22

Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia (2013) 1.22

Genetic and biochemical dissection of the mitochondrial protein-import machinery. Curr Genet (1995) 1.22

The impact of regional deprivation and individual socio-economic status on the prevalence of Type 2 diabetes in Germany. A pooled analysis of five population-based studies. Diabet Med (2013) 1.21

Molecular characterization of LbpB, the second lactoferrin-binding protein of Neisseria meningitidis. Mol Microbiol (1998) 1.21

The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation. EMBO J (2001) 1.20

The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import. J Biol Chem (1992) 1.19

Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. J Biol Chem (1994) 1.19

Mitochondrial import of subunit Va of cytochrome c oxidase characterized with yeast mutants. J Biol Chem (1995) 1.18

Mitochondrial receptor complex from Neurospora crassa and Saccharomyces cerevisiae. Methods Enzymol (1995) 1.16

The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins. Mol Cell Biol (1995) 1.15

The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases. Biochim Biophys Acta (2011) 1.15

The bacterial N-end rule pathway: expect the unexpected. Mol Microbiol (2010) 1.15

Mitochondrial protein import: specific recognition and membrane translocation of preproteins. J Membr Biol (1993) 1.12

Biogenesis of the mitochondrial receptor complex. Two receptors are required for binding of MOM38 to the outer membrane surface. J Biol Chem (1993) 1.12

Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae. FEBS Lett (1992) 1.11