Published in Cell on May 28, 1999
Structural basis of interdomain communication in the Hsc70 chaperone. Mol Cell (2005) 3.34
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci U S A (2009) 2.77
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol (2003) 2.47
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep (2000) 1.64
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling. Proc Natl Acad Sci U S A (2006) 1.45
Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J Cell Biol (2009) 1.42
Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol Biol Cell (2000) 1.39
Emission of membrane vesicles: roles in complement resistance, immunity and cancer. Springer Semin Immunopathol (2005) 1.39
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol (2005) 1.34
Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane. Proc Natl Acad Sci U S A (2005) 1.32
The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393-507) in complex with the peptide NRLLLTG. Protein Sci (2003) 1.24
The movement protein NSm of tomato spotted wilt tospovirus (TSWV): RNA binding, interaction with the TSWV N protein, and identification of interacting plant proteins. Proc Natl Acad Sci U S A (2000) 1.22
The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Infect Immun (2004) 1.21
The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation. EMBO J (2001) 1.20
Virus-host interactions during movement processes. Plant Physiol (2005) 1.14
Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J (2005) 1.13
Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol (2010) 1.11
Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro. J Cereb Blood Flow Metab (2007) 1.06
The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J (2002) 1.06
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem (2012) 1.06
Keep the traffic moving: mechanism of the Hsp70 motor. Traffic (2006) 1.04
Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements. Proc Natl Acad Sci U S A (2005) 1.04
A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import. Mol Cell Biol (2006) 1.03
Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role. Mol Cell Biol (2000) 1.01
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00
Residues of Tim44 involved in both association with the translocon of the inner mitochondrial membrane and regulation of mitochondrial Hsp70 tethering. Mol Cell Biol (2008) 1.00
Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins. Mol Cell Biol (2001) 0.98
Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet (2010) 0.96
Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. J Biol Chem (2005) 0.95
Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol (2005) 0.95
Models of post-translational protein translocation. Biophys J (2000) 0.95
Crystallization of a functionally intact Hsc70 chaperone. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.94
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med (2009) 0.94
Understanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components. J Biol Chem (2010) 0.93
The contribution of mitochondrial function to reproductive aging. J Assist Reprod Genet (2011) 0.91
Chaperoning erythropoiesis. Blood (2008) 0.91
The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria. EMBO J (2002) 0.88
Primary sequence that determines the functional overlap between mitochondrial heat shock protein 70 Ssc1 and Ssc3 of Saccharomyces cerevisiae. J Biol Chem (2011) 0.87
Role of membrane contact sites in protein import into mitochondria. Protein Sci (2015) 0.84
Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation. Nat Struct Mol Biol (2016) 0.84
Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis. PLoS One (2015) 0.83
Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix. Int J Biochem Cell Biol (2009) 0.83
Protein folding taking shape. Workshop on molecular chaperones. EMBO Rep (2001) 0.83
Evidence for non-circadian light/dark-regulated expression of Hsp70s in spinach leaves. Plant Physiol (2001) 0.80
Engineering protocells: prospects for self-assembly and nanoscale production-lines. Life (Basel) (2015) 0.80
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth. Int J Mol Sci (2013) 0.78
The functional interaction of mitochondrial Hsp70s with the escort protein Zim17 is critical for Fe/S biogenesis and substrate interaction at the inner membrane preprotein translocase. J Biol Chem (2013) 0.78
Ancient gene duplication provided a key molecular step for anaerobic growth of Baker's yeast. Mol Biol Evol (2011) 0.76
Role of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocation. Mol Biol Cell (2014) 0.75
Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. J Biol Chem (2016) 0.75
Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J Cell Biol (2016) 0.75
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
The heat-shock proteins. Annu Rev Genet (1988) 22.28
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature (1988) 11.00
Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci U S A (1984) 7.20
The heat shock response. CRC Crit Rev Biochem (1985) 6.82
Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions. Cell (1980) 6.17
Consensus sequence for Escherichia coli heat shock gene promoters. Proc Natl Acad Sci U S A (1985) 6.04
Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin. Proc Natl Acad Sci U S A (1982) 5.39
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12
The translation machinery and 70 kd heat shock protein cooperate in protein synthesis. Cell (1992) 4.39
Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila. Mol Cell Biol (1982) 4.26
Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth. Cell (1984) 3.83
Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature (1998) 3.77
Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae. Mol Cell Biol (1987) 3.75
Mitochondrial preprotein translocase. Annu Rev Cell Dev Biol (1997) 3.68
Mitochondrial protein import. Biochim Biophys Acta (1989) 3.66
Heat-shock proteins as molecular chaperones. Eur J Biochem (1994) 3.26
Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock. Proc Natl Acad Sci U S A (1982) 3.23
Sequence organization of two recombinant plasmids containing genes for the major heat shock-induced protein of D. melanogaster. Cell (1979) 3.21
Primary sequence of the 5' flanking regions of the Drosophila heat shock genes in chromosome subdivision 67B. Nucleic Acids Res (1981) 3.21
A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol (2001) 3.06
Molecular evolution of the HSP70 multigene family. J Mol Evol (1994) 3.00
Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature (1997) 2.88
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell (1987) 2.61
Effect of cycloheximide on RNA metabolism early in productive infection with adenovirus 2. J Virol (1974) 2.56
Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Mol Cell Biol (1996) 2.53
Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.52
Yeast Hsp70 RNA levels vary in response to the physiological status of the cell. J Bacteriol (1989) 2.51
Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol (2001) 2.46
Differential regulation of the 70K heat shock gene and related genes in Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.45
Getting newly synthesized proteins into shape. Cell (2000) 2.45
Functional specificity among Hsp70 molecular chaperones. Science (1997) 2.45
Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms. J Biol Chem (1988) 2.43
Expression of Drosophila heat-shock cognate genes during heat shock and development. Dev Biol (1983) 2.40
Primer extension analysis of RNA. Methods Enzymol (1989) 2.38
Transport of F1-ATPase subunit beta into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett (1986) 2.33
Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutation. J Bacteriol (1990) 2.30
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process. J Cell Biol (2001) 2.29
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J (1997) 2.28
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28
The role of Sis1 in the maintenance of the [RNQ+] prion. EMBO J (2001) 2.26
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem (2000) 2.26
Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.25
Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures. Mol Cell Biol (1985) 2.24
Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J (1985) 2.19
MOM19, an import receptor for mitochondrial precursor proteins. Cell (1989) 2.18
Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences. J Biol Chem (1991) 2.17
The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex. EMBO J (1998) 2.17
Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.14
SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth. Proc Natl Acad Sci U S A (1987) 2.10
Assaying protein import into mitochondria. Methods Cell Biol (2001) 2.04
Distinct steps in the import of ADP/ATP carrier into mitochondria. J Biol Chem (1987) 2.02
Ancient heat shock gene is dispensable. J Bacteriol (1988) 2.01
A mitochondrial import receptor for the ADP/ATP carrier. Cell (1990) 1.95
How do polypeptides cross the mitochondrial membranes? Cell (1990) 1.91
Protein folding in vivo: unraveling complex pathways. Cell (1997) 1.90
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (1990) 1.90
Multiple actin-related sequences in the Drosophila melanogaster genome. Cell (1980) 1.86
Zuotin, a ribosome-associated DnaJ molecular chaperone. EMBO J (1998) 1.84
Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.82
Analysis of mitochondrial protein import using translocation intermediates and specific antibodies. Methods Cell Biol (1991) 1.81
Analysis of early adenovirus 2 RNA using Eco R-R1 viral DNA fragments. J Virol (1975) 1.80
Transcriptional regulation of SSA3, an HSP70 gene from Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.77
Four Drosophila heat shock genes at 67B: characterization of recombinant plasmids. Nucleic Acids Res (1980) 1.76
Two clusters of genes for major chorion proteins of Drosophila melanogaster. Cell (1980) 1.75
Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol (1993) 1.73
Expression and localization of Drosophila melanogaster hsp70 cognate proteins. Mol Cell Biol (1986) 1.72
Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol (1990) 1.72
Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71
Mitochondrial molecular chaperones: their role in protein translocation. Trends Biochem Sci (1994) 1.70
Putative promoter elements for the ribosomal RNA genes of the thermoacidophilic archaebacterium Sulfolobus sp. strain B12. Nucleic Acids Res (1987) 1.68
Positive and negative regulation of basal expression of a yeast HSP70 gene. Mol Cell Biol (1989) 1.68
Genetic evidence for a functional relationship between Hsp104 and Hsp70. J Bacteriol (1993) 1.68
The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell (1993) 1.67
Regulation of a yeast HSP70 gene by a cAMP responsive transcriptional control element. EMBO J (1990) 1.67
Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem (1997) 1.66
The glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1. Mol Cell Biol (1999) 1.65
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J Cell Biol (2001) 1.65
Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep (2000) 1.64
Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett (1990) 1.60
The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J (2001) 1.60
Genes for three Drosophila heat-shock-induced proteins at a single locus. Proc Natl Acad Sci U S A (1980) 1.59
Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature (1992) 1.56
Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature (1999) 1.56
Partner proteins determine multiple functions of Hsp70. Trends Cell Biol (1995) 1.55
Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53
Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem (1999) 1.52
Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site. J Cell Biol (1988) 1.52
A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation. Proc Natl Acad Sci U S A (1994) 1.51
Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J (1996) 1.51