Published in J Biol Chem on March 29, 2001
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase. Proc Natl Acad Sci U S A (2002) 1.78
Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence. Nucleic Acids Res (2007) 1.60
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis (2006) 1.42
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO J (2004) 1.34
Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI-DNA complexes. Nucleic Acids Res (2005) 1.17
Control of catalytic cycle by a pair of analogous tRNA modification enzymes. J Mol Biol (2010) 1.06
DNA bending by M.EcoKI methyltransferase is coupled to nucleotide flipping. Nucleic Acids Res (2005) 1.05
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. RNA (2010) 0.99
Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo. Methods Enzymol (2007) 0.99
Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferase. Nucleic Acids Res (2005) 0.93
Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor. Adv Protein Chem Struct Biol (2012) 0.91
Mutational analysis of conserved residues in HhaI DNA methyltransferase. Nucleic Acids Res (2002) 0.90
Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase. Nucleic Acids Res (2011) 0.90
Hyperthermophilic DNA methyltransferase M.PabI from the archaeon Pyrococcus abyssi. Appl Environ Microbiol (2006) 0.88
New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer. Aging Dis (2013) 0.85
DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc (2014) 0.83
DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism. Biochemistry (2013) 0.83
A directed evolution design of a GCG-specific DNA hemimethylase. Nucleic Acids Res (2009) 0.83
Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer. Aging Dis (2015) 0.82
Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS? Biology (Basel) (2014) 0.81
Transducing methyltransferase activity into electrical signals in a carbon nanotube-DNA device(). Chem Sci (2011) 0.81
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies. J Mol Model (2011) 0.79
Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor. Nucleic Acids Res (2014) 0.76
Metadynamics simulation study on the conformational transformation of HhaI methyltransferase: an induced-fit base-flipping hypothesis. Biomed Res Int (2014) 0.75
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Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog. Nat Struct Biol (2001) 3.04
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Investigation of restriction-modification enzymes from M. varians RFL19 with a new type of specificity toward modification of substrate. Nucleic Acids Res (1985) 1.93
Purification and properties of the Eco57I restriction endonuclease and methylase--prototypes of a new class (type IV). Nucleic Acids Res (1992) 1.69
Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J Mol Biol (1996) 1.68
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases. Nucleic Acids Res (1998) 1.60
Restriction endonucleases of a new type. Gene (1988) 1.57
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI. J Mol Biol (1997) 1.55
Interaction of AluI, Cfr6I and PvuII restriction-modification enzymes with substrates containing either N4-methylcytosine or 5-methylcytosine. Biochim Biophys Acta (1987) 1.54
Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution. EMBO J (1998) 1.33
Cloning and sequence analysis of the genes coding for Eco57I type IV restriction-modification enzymes. Nucleic Acids Res (1992) 1.31
Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J Biol Chem (2000) 1.18
Functional roles of the conserved aromatic amino acid residues at position 108 (motif IV) and position 196 (motif VIII) in base flipping and catalysis by the N6-adenine DNA methyltransferase from Thermus aquaticus. Biochemistry (1999) 1.12
Chemical display of thymine residues flipped out by DNA methyltransferases. Nucleic Acids Res (1998) 1.00
Crystal structure of the HhaI DNA methyltransferase. Cold Spring Harb Symp Quant Biol (1993) 0.98
Alw26I, Eco31I and Esp3I--type IIs methyltransferases modifying cytosine and adenine in complementary strands of the target DNA. Nucleic Acids Res (1992) 0.94
Identification of the binding site for the extrahelical target base in N6-adenine DNA methyltransferases by photo-cross-linking with duplex oligodeoxyribonucleotides containing 5-iodouracil at the target position. J Biol Chem (1999) 0.91
A DNA-binding peptide from a phage display library. Nucleosides Nucleotides Nucleic Acids (2001) 0.88
Synthesis and physical characterization of DNA fragments containing N4-methylcytosine and 5-methylcytosine. Nucleic Acids Res (1987) 0.88
Bisulfite sequencing protocol displays both 5-methylcytosine and N4-methylcytosine. Anal Biochem (1999) 0.86
Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. Biochemistry (2000) 0.86
Sequence similarity among type-II restriction endonucleases, related by their recognized 6-bp target and tetranucleotide-overhang cleavage. Gene (1995) 0.83
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Mechanistic and active-site studies on D(--)-mandelate dehydrogenase from Rhodotorula graminis. Biochem J (1992) 0.83
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Construction of a deletion library using a mixture of 5'-truncated primers for inverse PCR (IPCR). Nucleic Acids Res (1997) 0.80
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A pair of single-strand and double-strand DNA cytosine-N4 methyltransferases from Bacillus centrosporus. Biol Chem (1998) 0.76
[Fluorescent-serological detection of the rabies virus strain Flury-LEP in the brain. I. Studies in guinea pigs]. Berl Munch Tierarztl Wochenschr (1969) 0.75
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[Retransmission, to cattle, of a tumor of NMRI mice, presumably induced by bovine leukosis tissue]. Zentralbl Veterinarmed B (1970) 0.75
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[Adsorption of lymphocytes in cattle leukocyte cultures in leukosis]. Zentralbl Bakteriol Orig (1966) 0.75
[Electrophoretic description of protein extracts from leukocytes and lymph node cells of normal cattle and those suffering leukosis]. Zentralbl Veterinarmed B (1966) 0.75
[The pathology of the Maedi disease of sheep]. Berl Munch Tierarztl Wochenschr (1976) 0.75
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[Rabies in dogs experimentally infected with street virus and immunized with Flury LEP virus thereafter (author's transl)]. Zentralbl Bakteriol Orig A (1973) 0.75
Transmission of bovine leukosis by serum, blood, bone-marrow and leukocytes. Bibl Haematol (1968) 0.75
[The importance of eosinophilic leucocytes in bovine leukosis]. Zentralbl Veterinarmed B (1971) 0.75
[Preparation of white blood cells from cattle for cell culture]. Berl Munch Tierarztl Wochenschr (1965) 0.75
[Transmission of bovine leukosis by colostrum and milk]. Dtsch Tierarztl Wochenschr (1971) 0.75
[Experimental studies of the transmission of rabies virus infection among mice under natural conditions]. Zentralbl Bakteriol Orig A (1972) 0.75
Experiments on the transmission of bovine leukosis by colostrum and milk. Bibl Haematol (1968) 0.75
[Studies of the giant cell formation, cell phagocytosis and lymphocyte adsorption in the culture of white blood cells of the cattle]. Berl Munch Tierarztl Wochenschr (1968) 0.75
[Visna in the goat]. Zentralbl Veterinarmed B (1978) 0.75
[Visna virus-like particles in cultures of choroid plexus cells of a goat with symptoms of Visna infection]. Zentralbl Veterinarmed B (1974) 0.75
[Studies on chromosome anomalies in bovine leukosis]. Berl Munch Tierarztl Wochenschr (1971) 0.75
[Studies on Newcastle disease virus to determine a testing system for virulicidal chemical disinfectants]. Berl Munch Tierarztl Wochenschr (1972) 0.75
[Epidemiology of rabies in rats and mice]. Berl Munch Tierarztl Wochenschr (1969) 0.75
Affinity photo-crosslinking study of the DNA base flipping pathway by HhaI methyltransferase. Nucleic Acids Symp Ser (2000) 0.75