Published in Nature on April 12, 2001
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol (2003) 3.60
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
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Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest (2010) 2.32
Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc Natl Acad Sci U S A (2004) 2.23
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Natl Acad Sci U S A (2003) 2.21
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med (2013) 2.19
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci (2011) 2.17
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol (2001) 2.07
A covering method for detecting genetic associations between rare variants and common phenotypes. PLoS Comput Biol (2010) 1.98
Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A (2006) 1.95
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Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. Am J Physiol Heart Circ Physiol (2004) 1.88
Endocannabinoid signaling is critical for habit formation. Front Integr Neurosci (2007) 1.81
Supply and demand for endocannabinoids. Trends Neurosci (2011) 1.78
The endocannabinoid system in brain reward processes. Br J Pharmacol (2008) 1.71
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology (Berl) (2003) 1.61
Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron (2005) 1.58
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The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J (2005) 1.50
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One (2008) 1.49
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J (2005) 1.48
Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. Br J Pharmacol (2010) 1.45
Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. Obesity (Silver Spring) (2012) 1.41
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes (2008) 1.39
CB1 cannabinoid receptor-mediated modulation of food intake in mice. Br J Pharmacol (2005) 1.38
Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. J Neurosci (2008) 1.37
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol (2003) 1.33
Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users. Psychopharmacology (Berl) (2007) 1.32
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol Sci (2008) 1.30
Endocannabinoid signalling in the blood of patients with schizophrenia. Lipids Health Dis (2003) 1.29
CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice. Diabetes (2010) 1.29
Endocannabinoids in liver disease. Hepatology (2011) 1.27
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes (2011) 1.26
Disruption of CB(1) receptor signaling impairs extinction of spatial memory in mice. Psychopharmacology (Berl) (2004) 1.23
Endocannabinoids and the control of energy homeostasis. J Biol Chem (2008) 1.22
The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications. Br J Pharmacol (2011) 1.21
Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. J Neurosci (2010) 1.19
Identification of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry (2007) 1.17
Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells. Br J Pharmacol (2007) 1.15
Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc Natl Acad Sci U S A (2008) 1.15
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. Acta Physiol (Oxf) (2011) 1.14
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats. Psychopharmacology (Berl) (2005) 1.13
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol (2007) 1.13
Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior. Psychopharmacology (Berl) (2007) 1.11
Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex. Neuron (2009) 1.10
2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab (2012) 1.09
Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids. PLoS One (2012) 1.09
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. Lipids Health Dis (2010) 1.09
Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function. Ann Surg (2008) 1.09
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. Br J Pharmacol (2009) 1.08
The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends Neurosci (2012) 1.08
The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food. Psychopharmacology (Berl) (2004) 1.07
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications. Hypertens Res (2011) 1.06
Obesity and appetite control. Exp Diabetes Res (2012) 1.05
Endocannabinoid signalling: has it got rhythm? Br J Pharmacol (2010) 1.04
Endocannabinoid signalling in reward and addiction. Nat Rev Neurosci (2015) 1.04
The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats. Psychopharmacology (Berl) (2005) 1.04
Endocannabinoid signalling and the deteriorating brain. Nat Rev Neurosci (2015) 1.03
Appetite and energy balance signals from adipocytes. Philos Trans R Soc Lond B Biol Sci (2006) 1.03
Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice. Nutr Metab (Lond) (2011) 1.03
Potential role of the endocannabinoid receptor antagonist rimonabant in the management of cardiometabolic risk: a narrative review of available data. Vasc Health Risk Manag (2007) 1.02
Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects. Nutr Metab (Lond) (2011) 1.02
Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons? Physiol Behav (2007) 1.02
Endocannabinoid overload. Mol Pharmacol (2010) 1.01
Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol Pharmacol (2006) 1.01
Endocannabinoids and their implications for epilepsy. Epilepsy Curr (2005) 1.00
The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific. Psychopharmacology (Berl) (2007) 1.00
New insights on the role of the endocannabinoid system in the regulation of energy balance. Int J Obes (Lond) (2015) 1.00
Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis. Diabetes (2011) 1.00
Sex differences in the cannabinoid modulation of appetite, body temperature and neurotransmission at POMC synapses. Neuroendocrinology (2009) 1.00
Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc Natl Acad Sci U S A (2005) 0.99
Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. Proc Natl Acad Sci U S A (2013) 0.99
Estradiol signaling in the regulation of reproduction and energy balance. Front Neuroendocrinol (2012) 0.99
A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology (2010) 0.99
Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis. J Biol Chem (2012) 0.98
Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. PLoS One (2012) 0.98
Hepatitis C virus induces the cannabinoid receptor 1. PLoS One (2010) 0.98
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation. Sci Signal (2012) 0.97
Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice. Br J Pharmacol (2006) 0.97
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Brain regulation of energy balance and body weight. Rev Endocr Metab Disord (2013) 0.96
Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade. Proc Natl Acad Sci U S A (2013) 0.96
Endocannabinoids and the regulation of body fat: the smoke is clearing. J Clin Invest (2003) 0.95
Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain. J Agric Food Chem (2010) 0.95
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going? Neuropsychopharmacology (2017) 0.95
Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Neuron (2011) 0.94
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