Published in Neuron on March 01, 2001
Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol (2005) 5.16
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology (2009) 2.78
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J (2004) 2.50
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J Cell Biol (2003) 2.42
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A (2004) 2.36
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol (2002) 2.10
Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res (2008) 1.92
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. Mol Cell Biol (2004) 1.74
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol (2002) 1.69
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol (2006) 1.60
Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J (2005) 1.49
miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev (2011) 1.48
Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol Cell Biol (2003) 1.41
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.41
Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J Neurosci (2010) 1.37
Cell cycle molecules define a pathway required for neuron death in development and disease. Biochim Biophys Acta (2006) 1.35
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest (2004) 1.34
Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate. EMBO J (2001) 1.32
The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway. J Cell Biol (2005) 1.32
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J Cell Biol (2002) 1.28
Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite. Mol Cell Biol (2005) 1.25
Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem (2006) 1.25
Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A (2006) 1.23
Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. J Clin Invest (2009) 1.22
Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering. Proc Natl Acad Sci U S A (2004) 1.20
The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiol Aging (2007) 1.19
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood (2007) 1.18
MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. J Immunol (2009) 1.17
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Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol (2005) 1.16
c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proc Natl Acad Sci U S A (2001) 1.14
JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol (2004) 1.13
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol (2003) 1.12
Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol Cell Biol (2005) 1.10
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci (2009) 1.10
MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood (2007) 1.10
p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J Biol Chem (2010) 1.09
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci (2007) 1.08
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Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. Cell Death Differ (2009) 1.03
Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death Dis (2013) 1.03
Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem (2010) 1.02
Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem (2010) 1.00
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol (2005) 1.00
The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons. BMC Neurosci (2011) 0.97
BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells. PLoS One (2011) 0.97
Regulation of Bim in Health and Disease. Oncotarget (2015) 0.95
A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons. Cell Death Differ (2013) 0.95
Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Res (2012) 0.95
Programmed cell death and new discoveries in the genetics of parkinsonism. J Neurochem (2007) 0.94
The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons. Nucleic Acids Res (2009) 0.94
Pin1 in neuronal apoptosis. Cell Cycle (2007) 0.94
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis (2008) 0.93
The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PLoS One (2012) 0.93
PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats. Neurobiol Dis (2012) 0.93
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1. Biochem J (2003) 0.92
A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells. J Cell Biol (2004) 0.92
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Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem (2005) 0.91
Role of Bim in diallyl trisulfide-induced cytotoxicity in human cancer cells. J Cell Biochem (2011) 0.91
Afferent deprivation elicits a transcriptional response associated with neuronal survival after a critical period in the mouse cochlear nucleus. J Neurosci (2008) 0.91
Programmed cell death during neuronal development: the sympathetic neuron model. Cell Death Differ (2014) 0.90
Neuronal apoptosis: BH3-only proteins the real killers? J Bioenerg Biomembr (2004) 0.90
Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase. J Virol (2007) 0.89
Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death. BMC Genomics (2011) 0.89
The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice. Sci Rep (2012) 0.89
BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. Oncogene (2008) 0.88
Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells. Mol Carcinog (2011) 0.87
Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Exp Eye Res (2010) 0.87
The role of the ubiquitin proteasome system in ischemia and ischemic tolerance. Neuroscientist (2009) 0.86
In vitro and in vivo assays for osteoclast apoptosis. Biol Proced Online (2005) 0.86
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1. Cell Death Differ (2013) 0.86
Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice. J Histochem Cytochem (2008) 0.85
Targeting the regulatory machinery of BIM for cancer therapy. Crit Rev Eukaryot Gene Expr (2012) 0.84
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Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. J Neurochem (2008) 0.82
Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells. J Biol Chem (2014) 0.82
Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. Cell Death Differ (2014) 0.81
BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis (2010) 0.81
N-cadherin mediates neuronal cell survival through Bim down-regulation. PLoS One (2012) 0.81
Epstein-Barr virus latent membrane protein 2A contributes to anoikis resistance through ERK activation. J Virol (2013) 0.81
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. Biochem J (2013) 0.80
Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo. Am J Blood Res (2012) 0.80
Multifunctional protein APPL2 contributes to survival of human glioma cells. Mol Oncol (2012) 0.80
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Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis. J Histochem Cytochem (2011) 0.79
BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin. Eur J Neurosci (2010) 0.79
Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Mol Cell Biol (2010) 0.79
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