Published in Proc Natl Acad Sci U S A on October 14, 2004
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med (2013) 8.89
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta (2006) 7.33
BAX activation is initiated at a novel interaction site. Nature (2008) 6.07
Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol (2005) 5.16
BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell (2010) 2.89
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis (2007) 2.82
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. J Exp Med (2005) 1.67
Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem (2006) 1.65
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol (2008) 1.63
A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci U S A (2005) 1.60
The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol (2008) 1.44
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood (2009) 1.37
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. J Clin Invest (2009) 1.22
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
Evading apoptosis in cancer. Trends Cell Biol (2013) 1.17
Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. Cancer Epidemiol Biomarkers Prev (2009) 1.17
Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci U S A (2007) 1.12
Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells. Cell Death Differ (2010) 1.12
MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood (2007) 1.10
Noxa/Mcl-1 balance regulates susceptibility of cells to camptothecin-induced apoptosis. Neoplasia (2007) 1.09
BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2. Cell Death Differ (2007) 1.07
RACK1 and CIS mediate the degradation of BimEL in cancer cells. J Biol Chem (2008) 1.05
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825. Blood (2007) 1.05
MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM. Leukemia (2009) 1.05
NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Blood (2008) 1.04
Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim. Cell Cycle (2009) 1.04
Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. Cell Death Differ (2009) 1.03
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. Adv Enzyme Regul (2007) 1.01
Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim. Infect Immun (2008) 0.99
The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons. BMC Neurosci (2011) 0.97
Leptin protects hippocampal CA1 neurons against ischemic injury. J Neurochem (2008) 0.96
Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells. Exp Hematol (2008) 0.96
Regulation of Bim in Health and Disease. Oncotarget (2015) 0.95
Pin1 in neuronal apoptosis. Cell Cycle (2007) 0.94
Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget (2014) 0.94
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis (2008) 0.93
Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem (2011) 0.93
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Mol Cell Biol (2009) 0.92
Targeting cancer by binding iron: Dissecting cellular signaling pathways. Oncotarget (2015) 0.91
Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types. Br J Cancer (2010) 0.91
Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration. Cell Death Differ (2014) 0.91
Inhibition of MEK/ERK1/2 sensitizes lymphoma cells to sorafenib-induced apoptosis. Leuk Res (2010) 0.89
The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. J Virol (2009) 0.89
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Adv Enzyme Regul (2008) 0.89
Characterization of ERK docking domain inhibitors that induce apoptosis by targeting Rsk-1 and caspase-9. BMC Cancer (2011) 0.88
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Differ (2012) 0.88
Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J Bioenerg Biomembr (2005) 0.87
Direct Activation of Bax Protein for Cancer Therapy. Med Res Rev (2015) 0.86
Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry. PLoS Pathog (2012) 0.86
MicroRNA and signaling pathways in gastric cancer. Cancer Gene Ther (2014) 0.86
Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? Front Oncol (2013) 0.86
A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res (2014) 0.85
Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers. Genes Cancer (2013) 0.85
Targeting the regulatory machinery of BIM for cancer therapy. Crit Rev Eukaryot Gene Expr (2012) 0.84
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. J Biol Chem (2011) 0.84
Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer (2011) 0.84
Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells. J Biol Chem (2014) 0.82
PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes. Immunol Lett (2010) 0.82
PINCH: More than just an adaptor protein in cellular response. J Cell Physiol (2011) 0.81
Apoptosis in leukemias: regulation and therapeutic targeting. Cancer Treat Res (2010) 0.81
Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway. J Virol (2011) 0.81
Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation. Respir Res (2011) 0.81
Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo. Am J Blood Res (2012) 0.80
Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM. FEBS Open Bio (2014) 0.79
Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML. Physiol Genomics (2014) 0.79
SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory. J Immunol (2012) 0.78
ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients. Clin Epigenetics (2011) 0.78
mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection. PLoS One (2014) 0.78
JAK2V617F drives Mcl-1 expression and sensitizes hematologic cell lines to dual inhibition of JAK2 and Bcl-xL. PLoS One (2015) 0.77
Role of T cell death in maintaining immune tolerance during persistent viral hepatitis. World J Gastroenterol (2013) 0.76
Down-Regulation of Ribosomal S6 kinase RPS6KA6 in Acute Myeloid Leukemia Patients. Cell J (2016) 0.76
FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators. J Clin Invest (2012) 0.76
Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt. Exp Eye Res (2016) 0.76
Bone marrow microenvironment-derived signals induce Mcl-1 dependence in multiple myeloma. Blood (2017) 0.75
Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer. EPMA J (2012) 0.75
Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. Oncotarget (2015) 0.75
Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget (2016) 0.75
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science (1999) 11.96
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol (1997) 9.18
Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J (1998) 7.17
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell (1999) 5.92
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J (1998) 5.78
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem (2003) 4.55
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol (2003) 4.25
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene (2003) 3.96
Control of T cell viability. Annu Rev Immunol (2004) 3.89
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron (2001) 3.47
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron (2001) 3.07
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol (2003) 2.63
Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem (2003) 2.31
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
Signaling life and death in the thymus: timing is everything. Science (2003) 2.20
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol (2002) 2.10
Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol (2001) 2.03
Lymphocide: cytokines and the control of lymphoid homeostasis. Nat Rev Immunol (2002) 1.70
Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. J Biol Chem (2002) 1.51
Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene (2004) 1.43
Apoptosis during lymphoid development. Curr Opin Immunol (2003) 1.02
Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis. Mol Immunol (2003) 1.01
Cell death: critical control points. Cell (2004) 22.56
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (2003) 9.55
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (2003) 4.92
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science (2005) 4.75
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A (2005) 4.63
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
A stapled BID BH3 helix directly binds and activates BAX. Mol Cell (2006) 3.86
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell (2003) 3.75
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell (2003) 3.35
Apoptosis in the development and maintenance of the immune system. Nat Immunol (2003) 3.02
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell (2002) 2.96
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc (2007) 2.71
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol (2003) 2.66
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun (2003) 2.65
Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A (2003) 2.54
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A (2005) 2.43
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood (2003) 2.35
A role for proapoptotic BID in the DNA-damage response. Cell (2005) 2.30
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev (2006) 2.20
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol (2004) 2.10
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell (2002) 2.09
Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell (2004) 2.09
Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell (2004) 1.92
FLT3 mutations in childhood acute lymphoblastic leukemia. Blood (2003) 1.91
BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol (2002) 1.84
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J (2005) 1.79
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res (2011) 1.74
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood (2007) 1.64
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J Biol Chem (2002) 1.62
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell (2004) 1.62
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell (2005) 1.55
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol (2006) 1.51
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol (2002) 1.42
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem (2005) 1.37
Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab (2006) 1.34
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res (2003) 1.32
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol (2003) 1.30
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood (2002) 1.30
A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem (2006) 1.26
p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells. FEBS Lett (2006) 1.26
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem (2004) 1.20
Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod (2002) 1.18
MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol (2003) 1.16
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem (2006) 1.13
Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep (2005) 1.13
Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology (2002) 1.12
Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response. J Biol Chem (2002) 1.10
p600, a unique protein required for membrane morphogenesis and cell survival. Proc Natl Acad Sci U S A (2005) 1.09
The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal (2009) 1.08
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res (2002) 1.05
Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci (2003) 1.04
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology (2003) 1.04
Community consultation and public disclosure: preliminary results from a new model. Acad Emerg Med (2011) 0.99
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC. Am J Physiol Cell Physiol (2003) 0.97
BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem (2004) 0.94
Cell death induced by granzyme C. Blood (2002) 0.93
Untangling the web: mitochondrial fission and apoptosis. Dev Cell (2004) 0.85
Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias. Curr Opin Hematol (2002) 0.83
Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9. FEBS Lett (2007) 0.83
Caspase regulation of genotoxin-induced neural precursor cell death. J Neurosci Res (2003) 0.83
Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain. Eur Surg Res (2002) 0.83
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PLoS One (2012) 0.80
Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets. Cell Cycle (2003) 0.75