Published in Nat Cell Biol on May 01, 2001
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A (2003) 11.53
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell (2006) 7.35
The relationship between force and focal complex development. J Cell Biol (2002) 6.26
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Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A (2005) 5.08
Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J (2007) 4.59
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
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High resolution traction force microscopy based on experimental and computational advances. Biophys J (2007) 3.89
Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophys J (2006) 3.83
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Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A (2010) 3.44
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J Cell Biol (2008) 3.44
Is the mechanical activity of epithelial cells controlled by deformations or forces? Biophys J (2005) 3.43
Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A (2001) 3.41
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nat Methods (2010) 3.35
Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. J Cell Biol (2001) 3.28
Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization. Biophys J (2002) 3.21
Integrins in cell migration--the actin connection. J Cell Sci (2009) 2.88
Force transduction by Triton cytoskeletons. J Cell Biol (2002) 2.83
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Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin. Mol Biol Cell (2004) 2.59
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell (2005) 2.51
Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A (2007) 2.47
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Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43
Cell organization in soft media due to active mechanosensing. Proc Natl Acad Sci U S A (2003) 2.41
Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol (2010) 2.36
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol (2009) 2.33
Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns. Biophys J (2005) 2.33
Force probing surfaces of living cells to molecular resolution. Nat Chem Biol (2009) 2.28
Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol (2008) 2.24
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol (2003) 2.18
Optimal matrix rigidity for stress fiber polarization in stem cells. Nat Phys (2010) 2.16
Fluctuations of intracellular forces during cell protrusion. Nat Cell Biol (2008) 2.13
Cytoskeletal coherence requires myosin-IIA contractility. J Cell Sci (2010) 2.13
Single-cell response to stiffness exhibits muscle-like behavior. Proc Natl Acad Sci U S A (2009) 2.11
Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension. Curr Biol (2010) 2.11
Magnetic microposts as an approach to apply forces to living cells. Proc Natl Acad Sci U S A (2007) 2.10
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol (2006) 2.08
FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proc Natl Acad Sci U S A (2005) 2.07
Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation. PLoS One (2009) 2.06
A quantitative analysis of contractility in active cytoskeletal protein networks. Biophys J (2008) 2.05
Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J (2003) 2.03
The initial steps of myofibril assembly: integrins pave the way. Nat Rev Mol Cell Biol (2009) 2.02
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol (2005) 2.02
The shape of motile cells. Curr Biol (2009) 2.00
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell (2004) 1.98
Quantifying cellular traction forces in three dimensions. Proc Natl Acad Sci U S A (2009) 1.98
Influence of type I collagen surface density on fibroblast spreading, motility, and contractility. Biophys J (2003) 1.97
Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun (2012) 1.96
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94
Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness. Proc Natl Acad Sci U S A (2012) 1.94
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Mechano-coupling and regulation of contractility by the vinculin tail domain. Biophys J (2007) 1.92
An adhesion-dependent switch between mechanisms that determine motile cell shape. PLoS Biol (2011) 1.90
Strength dependence of cadherin-mediated adhesions. Biophys J (2010) 1.86
Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol (2009) 1.86
Cell mechanosensitivity controls the anisotropy of focal adhesions. Proc Natl Acad Sci U S A (2004) 1.85
Live Cells Exert 3-Dimensional Traction Forces on Their Substrata. Cell Mol Bioeng (2009) 1.80
Spatial distribution and functional significance of activated vinculin in living cells. J Cell Biol (2005) 1.77
Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites. Proc Natl Acad Sci U S A (2009) 1.77
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
The regulation of traction force in relation to cell shape and focal adhesions. Biomaterials (2010) 1.72
A hitchhiker's guide to mechanobiology. Dev Cell (2011) 1.72
Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton (2008) 1.71
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell (2003) 1.70
Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol (2009) 1.69
Spatiotemporal constraints on the force-dependent growth of focal adhesions. Biophys J (2011) 1.69
Mechanosensation through integrins: cells act locally but think globally. Proc Natl Acad Sci U S A (2003) 1.67
Direct comparison of the spread area, contractility, and migration of balb/c 3T3 fibroblasts adhered to fibronectin- and RGD-modified substrata. Biophys J (2004) 1.65
Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods (2013) 1.64
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech Chem Biosyst (2005) 1.63
United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J Cell Sci (2012) 1.63
Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells. Int J Cell Biol (2012) 1.63
Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol (2013) 1.63
The hard life of soft cells. Cell Motil Cytoskeleton (2009) 1.61
Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc (2011) 1.60
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proc Natl Acad Sci U S A (2012) 1.59
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