Impact of local versus global ligand density on cellular adhesion.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMC 3806292)

Published in Nano Lett on March 22, 2011

Authors

Janosch A Deeg1, Ilia Louban, Daniel Aydin, Christine Selhuber-Unkel, Horst Kessler, Joachim P Spatz

Author Affiliations

1: Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstrasse 3, 70569 Stuttgart, Germany.

Articles citing this

Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions. Biophys J (2012) 1.30

Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front. Biophys J (2012) 1.03

Cell instructive microporous scaffolds through interface engineering. J Am Chem Soc (2012) 0.88

T cell activation is determined by the number of presented antigens. Nano Lett (2013) 0.86

RGD-conjugated rod-like viral nanoparticles on 2D scaffold improve bone differentiation of mesenchymal stem cells. Front Chem (2014) 0.83

Spatial organization of cell-adhesive ligands for advanced cell culture. Biotechnol J (2013) 0.80

Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration. Adv Healthc Mater (2015) 0.79

Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings. Int J Nanomedicine (2014) 0.76

Automated Defect and Correlation Length Analysis of Block Copolymer Thin Film Nanopatterns. PLoS One (2015) 0.76

Nanoscale titanium surface treatments for marrow progenitor culture. Nanomedicine (Lond) (2012) 0.76

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches. Cell Adh Migr (2016) 0.75

Capturing extracellular matrix properties in vitro: Microengineering materials to decipher cell and tissue level processes. Exp Biol Med (Maywood) (2016) 0.75

Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses. Front Bioeng Biotechnol (2015) 0.75

Manufacturing Cell Therapies Using Engineered Biomaterials. Trends Biotechnol (2017) 0.75

Can single molecule localization microscopy be used to map closely spaced RGD nanodomains? PLoS One (2017) 0.75

Articles cited by this

Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00

Integrins: versatility, modulation, and signaling in cell adhesion. Cell (1992) 34.06

Models for the specific adhesion of cells to cells. Science (1978) 28.03

Geometric control of cell life and death. Science (1997) 18.13

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol (2001) 14.08

Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol (2006) 11.29

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev Mol Cell Biol (2001) 10.74

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton (2005) 10.20

Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56

Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89

Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85

Activation of integrin function by nanopatterned adhesive interfaces. Chemphyschem (2004) 4.66

Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57

An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J Cell Biol (1991) 2.53

Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs. Biophys J (2004) 2.46

Single-cell force spectroscopy. J Cell Sci (2008) 2.29

Fibrillar structure and mechanical properties of collagen. J Struct Biol (1998) 2.24

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins. J Biol Chem (1994) 2.22

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. Eur J Cell Biol (2005) 1.93

Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Lett (2009) 1.75

Stability of adhesion clusters under constant force. Phys Rev Lett (2004) 1.55

Focal adhesions as mechanosensors: the two-spring model. Biosystems (2005) 1.47

Analyzing focal adhesion structure by atomic force microscopy. J Cell Sci (2005) 1.43

Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors. Biophys J (2010) 1.37

Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions. Acta Anat (Basel) (1995) 1.25

Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation. Chembiochem (2000) 1.22

Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol (2008) 1.08

Pattern stability under cell culture conditions--a comparative study of patterning methods based on PLL-g-PEG background passivation. Biomaterials (2005) 0.97

Human cornea and sclera studied by atomic force microscopy. Cell Tissue Res (1997) 0.96

Micro-nanostructured protein arrays: a tool for geometrically controlled ligand presentation. Small (2009) 0.91

Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.85

Physical interpretation of the maximum receptor-ligand bond spacing to ensure cell adhesion in ligand-coated substrates. Langmuir (2008) 0.80

Articles by these authors

Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials (2003) 5.34

Activation of integrin function by nanopatterned adhesive interfaces. Chemphyschem (2004) 4.66

Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94

Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57

Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD. PLoS Med (2005) 3.12

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33

[18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjug Chem (2004) 2.20

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity (2010) 2.18

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17

Adaptive force transmission in amoeboid cell migration. Nat Cell Biol (2009) 2.17

Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs. J Nucl Med (2004) 2.14

N-methylation of peptides: a new perspective in medicinal chemistry. Acc Chem Res (2008) 2.02

Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites. Cell Host Microbe (2009) 2.01

Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res (2006) 1.96

Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J Biol Chem (2006) 1.94

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. Eur J Cell Biol (2005) 1.93

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90

Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem (2010) 1.87

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81

Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Lett (2009) 1.75

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation. Chemistry (2003) 1.69

Asymmetric activation of the hsp90 dimer by its cochaperone aha1. Mol Cell (2010) 1.65

A conserved spider silk domain acts as a molecular switch that controls fibre assembly. Nature (2010) 1.65

The N-terminal domain of p53 is natively unfolded. J Mol Biol (2003) 1.62

Ligands for mapping alphavbeta3-integrin expression in vivo. Acc Chem Res (2009) 1.60

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew Chem Int Ed Engl (2008) 1.48

Carbohydrate-based mimetics in drug design: sugar amino acids and carbohydrate scaffolds. Chem Rev (2002) 1.46

In vivo anomalous diffusion and weak ergodicity breaking of lipid granules. Phys Rev Lett (2011) 1.45

Two characteristic regimes in frequency-dependent dynamic reorientation of fibroblasts on cyclically stretched substrates. Biophys J (2008) 1.44

Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces. Biomaterials (2007) 1.44

Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43

Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett (2008) 1.43

PET Imaging of Integrin αVβ3 Expression. Theranostics (2011) 1.41

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J (2012) 1.36

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. J Med Chem (2002) 1.31

PET imaging of CXCR4 receptors in cancer by a new optimized ligand. ChemMedChem (2011) 1.28

Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro Oncol (2009) 1.27

Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment. Biophys J (2007) 1.25

Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep (2009) 1.24

Quantitative analysis of single particle trajectories: mean maximal excursion method. Biophys J (2010) 1.24

Different sensitivity of human endothelial cells, smooth muscle cells and fibroblasts to topography in the nano-micro range. Acta Biomater (2009) 1.22

Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J Cell Sci (2009) 1.21

Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovasc Res (2008) 1.21

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. J Am Chem Soc (2010) 1.20

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol. Chembiochem (2003) 1.20

Serial section scanning electron microscopy (S3EM) on silicon wafers for ultra-structural volume imaging of cells and tissues. PLoS One (2012) 1.18

Cooperativity in adhesion cluster formation during initial cell adhesion. Biophys J (2008) 1.18

Optimized selective N-methylation of peptides on solid support. J Pept Sci (2006) 1.18

The structures of integrins and integrin-ligand complexes: implications for drug design and signal transduction. Angew Chem Int Ed Engl (2002) 1.17

First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clin Cancer Res (2004) 1.15

Tumor Targeting via Integrin Ligands. Front Oncol (2013) 1.15

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy. Proc Natl Acad Sci U S A (2009) 1.14

Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function. Mol Cell (2010) 1.14

PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. J Nucl Med (2011) 1.13

Intrinsic inhibition of the Hsp90 ATPase activity. J Biol Chem (2006) 1.13

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. J Biol Chem (2009) 1.12

Nanopatterning by block copolymer micelle nanolithography and bioinspired applications. Biointerphases (2011) 1.11

The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides. Mol Pharm (2011) 1.10

Transmembrane signal transduction of the alpha(IIb)beta(3) integrin. Protein Sci (2002) 1.10

In support of the BMRB. Nat Struct Mol Biol (2012) 1.09

p53--a natural cancer killer: structural insights and therapeutic concepts. Angew Chem Int Ed Engl (2006) 1.08

Cellular unbinding forces of initial adhesion processes on nanopatterned surfaces probed with magnetic tweezers. Nano Lett (2006) 1.08

A computational model of transmembrane integrin clustering. Structure (2004) 1.08

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis. J Org Chem (2005) 1.07

Site-specific presentation of single recombinant proteins in defined nanoarrays. Biointerphases (2007) 1.06

Switchable adhesive substrates: revealing geometry dependence in collective cell behavior. Biomaterials (2011) 1.06

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nat Struct Mol Biol (2011) 1.05

Cell interactions with hierarchically structured nano-patterned adhesive surfaces. Soft Matter (2009) 1.05

Synthesis and stereochemical assignment of DNA spore photoproduct analogues. Chemistry (2006) 1.04

Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. Chemistry (2007) 1.03

Photoswitched cell adhesion on surfaces with RGD peptides. J Am Chem Soc (2005) 1.03

N-methylation of peptides and proteins: an important element for modulating biological functions. Angew Chem Int Ed Engl (2012) 1.03

Mimicking cellular environments by nanostructured soft interfaces. Nano Lett (2007) 1.02

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett (2005) 1.02

Actin fusion proteins alter the dynamics of mechanically induced cytoskeleton rearrangement. PLoS One (2011) 1.02

Molecular targeting with peptides or peptide-polymer conjugates: just a question of size? J Nucl Med (2005) 1.02

Characterization of human saposins by NMR spectroscopy. Biochemistry (2006) 1.02

TMV nanorods with programmed longitudinal domains of differently addressable coat proteins. Nanoscale (2013) 1.01

Membrane-grafted hyaluronan films: a well-defined model system of glycoconjugate cell coats. J Am Chem Soc (2007) 1.01

Mechanical response analysis and power generation by single-cell stretching. Chemphyschem (2005) 1.01

Ovarian cancer cell proliferation and motility is induced by engagement of integrin alpha(v)beta3/Vitronectin interaction. Biol Chem (2003) 1.01

N-methylated cyclic pentaalanine peptides as template structures. J Am Chem Soc (2006) 1.01