Published in Proc Natl Acad Sci U S A on September 25, 2001
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol (2009) 7.77
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene (2009) 3.17
Substrate rigidity regulates the formation and maintenance of tissues. Biophys J (2005) 3.08
Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell (2012) 2.87
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron (2003) 2.86
Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med (2008) 2.68
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48
Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A (2007) 2.47
Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength. Biophys J (2009) 2.34
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol (2003) 2.18
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. Biophys J (2008) 1.99
Influence of type I collagen surface density on fibroblast spreading, motility, and contractility. Biophys J (2003) 1.97
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J Cell Sci (2011) 1.90
Stiffness gradients mimicking in vivo tissue variation regulate mesenchymal stem cell fate. PLoS One (2011) 1.86
Topography, cell response, and nerve regeneration. Annu Rev Biomed Eng (2010) 1.70
Direct comparison of the spread area, contractility, and migration of balb/c 3T3 fibroblasts adhered to fibronectin- and RGD-modified substrata. Biophys J (2004) 1.65
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech Chem Biosyst (2005) 1.63
Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. Biophys J (2008) 1.61
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation. Mol Biol Cell (2009) 1.60
Cellular responses to substrate topography: role of myosin II and focal adhesion kinase. Biophys J (2006) 1.58
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55
Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices. Mol Biol Cell (2008) 1.54
Neutrophil morphology and migration are affected by substrate elasticity. Blood (2009) 1.53
The emerging role of forces in axonal elongation. Prog Neurobiol (2011) 1.50
Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol Biol Cell (2007) 1.45
Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol (2007) 1.43
Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J Biol Chem (2008) 1.42
Focal adhesion size uniquely predicts cell migration. FASEB J (2012) 1.40
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO J (2010) 1.36
Biomechanical regulation of cell orientation and fate. Oncogene (2008) 1.31
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions. J Cell Physiol (2010) 1.29
Cellular and multicellular form and function. Adv Drug Deliv Rev (2007) 1.24
Stretch-induced stress fiber remodeling and the activations of JNK and ERK depend on mechanical strain rate, but not FAK. PLoS One (2010) 1.23
α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction. J Cell Sci (2014) 1.17
A new technique for calculating individual dermal fibroblast contractile forces generated within collagen-GAG scaffolds. Biophys J (2007) 1.17
Internet-based image analysis quantifies contractile behavior of individual fibroblasts inside model tissue. Biophys J (2003) 1.15
Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase. J Mol Cell Cardiol (2007) 1.14
Guiding cell migration by tugging. Curr Opin Cell Biol (2013) 1.14
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Sci Rep (2013) 1.13
The interplay between cell signalling and mechanics in developmental processes. Nat Rev Genet (2013) 1.13
Cellular scale anisotropic topography guides Schwann cell motility. PLoS One (2011) 1.12
Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions. Biol Cell (2010) 1.11
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci (2012) 1.07
Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry. Anal Chem (2009) 1.07
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol (2005) 1.07
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation (2013) 1.04
Focal adhesion kinase stabilizes the cytoskeleton. Biophys J (2011) 1.04
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol (2010) 1.02
FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration. J Cell Biol (2003) 1.00
Regulation of Epithelial-Mesenchymal Transition by Transmission of Mechanical Stress through Epithelial Tissues. Cancer Microenviron (2011) 0.95
Syndecan-2 regulates the migratory potential of melanoma cells. J Biol Chem (2009) 0.95
A predictive model of cell traction forces based on cell geometry. Biophys J (2010) 0.95
How matrix properties control the self-assembly and maintenance of tissues. Ann Biomed Eng (2011) 0.95
Netrin-1 attracts axons through FAK-dependent mechanotransduction. J Neurosci (2012) 0.94
Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology. Nat Protoc (2010) 0.94
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proc Natl Acad Sci U S A (2014) 0.94
Modelling cell migration strategies in the extracellular matrix. J Math Biol (2008) 0.93
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Exp Cell Res (2009) 0.93
Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing. Biopolymers (2011) 0.92
LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence. J Biol Chem (2013) 0.92
Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med (2013) 0.92
Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry (2010) 0.92
Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A. J Biol Chem (2014) 0.92
Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness. J Neurotrauma (2009) 0.90
Gradient biomaterials and their influences on cell migration. Interface Focus (2012) 0.89
Biomechanical regulation of mesenchymal cell function. Curr Opin Rheumatol (2013) 0.89
Intercellular stress reconstitution from traction force data. Biophys J (2014) 0.89
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil Cytoskeleton (2008) 0.87
Combining mechanical and optical approaches to dissect cellular mechanobiology. J Biomech (2009) 0.86
The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin. Mol Biol Cell (2016) 0.86
Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks. Acta Biomater (2014) 0.85
The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction. Soft Matter (2013) 0.85
Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater (2014) 0.84
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. PLoS One (2014) 0.83
Role of surface chemistry in protein remodeling at the cell-material interface. PLoS One (2011) 0.83
Contact guidance in human dermal fibroblasts is modulated by population pressure. J Anat (2005) 0.83
Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis (2015) 0.83
Localized application of mechanical and biochemical stimuli in 3-D culture. Dev Dyn (2008) 0.82
Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One (2012) 0.82
Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions. J Neurosci (2016) 0.81
Mechano-sensing by actin filaments and focal adhesion proteins. Commun Integr Biol (2012) 0.81
The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron (2011) 0.81
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol (2016) 0.81
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. Dev Biol (2014) 0.81
Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol (2001) 14.08
Mechanotransduction across the cell surface and through the cytoskeleton. Science (1993) 14.01
Cell movement is guided by the rigidity of the substrate. Biophys J (2000) 13.84
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys J (1999) 10.71
Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell (1997) 10.22
Flow-mediated endothelial mechanotransduction. Physiol Rev (1995) 10.13
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol (2001) 6.32
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A (1990) 5.25
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A (1992) 5.06
Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Methods Enzymol (1998) 4.03
Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophys J (2001) 4.01
Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. Am J Physiol Cell Physiol (2000) 3.97
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci (1999) 3.93
Cell migration: regulation of force on extracellular-matrix-integrin complexes. Trends Cell Biol (1998) 3.69
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci (1996) 3.52
High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate. Mol Biol Cell (1999) 3.46
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci (2000) 3.31
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol (1996) 3.21
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol (1998) 2.97
Characterising a kinesis response: time averaged measures of cell speed and directional persistence. Agents Actions Suppl (1983) 2.89
Interaction of focal adhesion kinase with cytoskeletal protein talin. J Biol Chem (1995) 2.68
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol (1999) 2.61
Cell adhesion: old and new questions. Trends Cell Biol (1999) 2.44
Regulation of the cell cycle by focal adhesion kinase. J Cell Biol (1998) 2.32
Zyxin: zinc fingers at sites of cell adhesion. Bioessays (1997) 2.21
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue. Exp Cell Res (1999) 1.86
Role of focal adhesion kinase in integrin signaling. Int J Biochem Cell Biol (1998) 1.83
Stress relaxation of contracted collagen gels: disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis. Exp Cell Res (1991) 1.59
Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals. Biochem Cell Biol (1996) 1.51
Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J Biol Chem (1998) 1.47
Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A (1999) 1.46
Pp125FAK is required for stretch dependent morphological response of endothelial cells. Oncogene (1998) 1.32
Pyk2 and FAK differentially regulate progression of the cell cycle. J Cell Sci (2000) 1.25
Impairment of mobility in endodermal cells by FAK deficiency. Exp Cell Res (1996) 1.22
Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content. Mol Biol Cell (1996) 1.07
Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants. J Biol Chem (1997) 1.04
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J (1982) 17.98
Cell movement is guided by the rigidity of the substrate. Biophys J (2000) 13.84
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol (1991) 9.39
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20
Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes. Appl Environ Microbiol (1997) 7.09
A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol (2001) 6.32
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell (1992) 6.08
Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med (1997) 5.93
Cell adhesion. Competition between nonspecific repulsion and specific bonding. Biophys J (1984) 5.72
Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus. Virology (1992) 5.64
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46
Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol (1995) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol (2000) 5.29
Racial differences in the use of cardiac catheterization after acute myocardial infarction. N Engl J Med (2001) 5.29
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science (2000) 5.27
Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A (1998) 4.59
POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45
Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med (1999) 4.30
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08
Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophys J (2001) 4.01
Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. Am J Physiol Cell Physiol (2000) 3.97
Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc Natl Acad Sci U S A (1994) 3.85
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Signal timing across the macaque visual system. J Neurophysiol (1998) 3.66
Traction forces in locomoting cells. Cell Motil Cytoskeleton (1995) 3.58
The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A (1999) 3.53
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin. Infect Immun (1998) 3.44
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. Proc Natl Acad Sci U S A (1987) 3.42
Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell (1994) 3.41
A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature (1999) 3.40
HIV requires multiple gp120 molecules for CD4-mediated infection. Nature (1990) 3.37
Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells. J Cell Biol (1996) 3.36
Criteria and recommendations for vitamin C intake. JAMA (1999) 3.32
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril (1979) 3.19
Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem (1987) 3.19
The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation (1978) 3.19
Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro (2014) 3.10
Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int (2007) 3.06
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A (1998) 3.05
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Changes in reliability of synaptic function as a mechanism for plasticity. Nature (1994) 2.97
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol (1998) 2.97
Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat Med (1996) 2.96
Facilitation and depression at single central synapses. Neuron (1995) 2.95
Vam3p structure reveals conserved and divergent properties of syntaxins. Nat Struct Biol (2001) 2.92
Effectiveness of laser therapy and topical desensitising agents in treating dentine hypersensitivity: a systematic review. J Oral Rehabil (2011) 2.91
Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr (2010) 2.91
A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (1997) 2.90
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem (2000) 2.89
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release (2001) 2.84
Coronectomy vs. total removal for third molar extraction: a systematic review. J Dent Res (2012) 2.84
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci (2001) 2.76
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Distinct types of rRNA operons exist in the genome of the actinomycete Thermomonospora chromogena and evidence for horizontal transfer of an entire rRNA operon. J Bacteriol (1999) 2.72
Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J (2000) 2.71
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res (1999) 2.69
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med (1998) 2.69
Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med (2001) 2.69
A high-affinity iron permease essential for Candida albicans virulence. Science (2000) 2.68
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell (1999) 2.68
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc Natl Acad Sci U S A (1998) 2.68
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A (1995) 2.67
Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest (1995) 2.65
Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev (2008) 2.62
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res (2001) 2.62
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol (1999) 2.61
Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes. Mol Genet Genomics (2004) 2.56
Biology and action of colony--stimulating factor-1. Mol Reprod Dev (1997) 2.52
The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Res (2001) 2.51
Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res (2001) 2.50
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50