Published in Nature on May 03, 2001
Regulatory networks define phenotypic classes of human stem cell lines. Nature (2008) 4.98
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nat Biotechnol (2011) 3.45
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One (2010) 2.34
Regulation of human neural precursor cells by laminin and integrins. J Neurosci Res (2006) 2.30
Passaging human neural stem cells. J Vis Exp (2007) 2.19
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene (2007) 1.92
Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol Syst Biol (2006) 1.90
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev (2006) 1.88
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci (2009) 1.72
Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs (2010) 1.67
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 1.62
Neural precursor cells and central nervous system radiation sensitivity. Semin Radiat Oncol (2009) 1.54
Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells (2009) 1.32
The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One (2012) 1.30
Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity. Nat Commun (2012) 1.24
Advances in stem cell therapy for spinal cord injury. J Clin Invest (2012) 1.24
Isolation and cultivation of neuronal precursor cells from the developing human enteric nervous system as a tool for cell therapy in dysganglionosis. Int J Colorectal Dis (2005) 1.23
Neural progenitor cells from postmortem adult human retina. Br J Ophthalmol (2005) 1.22
A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron (2014) 1.20
Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death Differ (2009) 1.19
Modeling the functional genomics of autism using human neurons. Mol Psychiatry (2011) 1.17
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A (2014) 1.11
Two factor reprogramming of human neural stem cells into pluripotency. PLoS One (2009) 1.11
The new stem cell biology: something for everyone. Mol Pathol (2003) 1.10
Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells. Int J Med Sci (2008) 1.10
Robust postmortem survival of murine vestibular and cochlear stem cells. J Assoc Res Otolaryngol (2007) 1.04
Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways. Sci Signal (2011) 1.03
Neurodegeneration and cell replacement. Philos Trans R Soc Lond B Biol Sci (2008) 1.01
Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells. Cell Mol Life Sci (2010) 1.01
Biophysical characteristics reveal neural stem cell differentiation potential. PLoS One (2011) 0.98
Applications of neural and mesenchymal stem cells in the treatment of gliomas. Expert Rev Anticancer Ther (2009) 0.97
CD133/prominin1 is prognostic for GBM patient's survival, but inversely correlated with cysteine cathepsins' expression in glioblastoma derived spheroids. Radiol Oncol (2011) 0.97
Nestin positive cells in adult human retina and in epiretinal membranes. Br J Ophthalmol (2003) 0.96
Human high intelligence is involved in spectral redshift of biophotonic activities in the brain. Proc Natl Acad Sci U S A (2016) 0.96
Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. J Comp Neurol (2009) 0.94
Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci (2008) 0.93
Expansion of multipotent stem cells from the adult human brain. PLoS One (2013) 0.93
Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease. Neurobiol Aging (2009) 0.92
Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation. PLoS One (2011) 0.92
Intra-operatively obtained human tissue: protocols and techniques for the study of neural stem cells. J Neurosci Methods (2009) 0.92
Proliferation zones in the axolotl brain and regeneration of the telencephalon. Neural Dev (2013) 0.91
Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. BMC Neurosci (2010) 0.91
Human cadaver multipotent stromal/stem cells isolated from arteries stored in liquid nitrogen for 5 years. Stem Cell Res Ther (2014) 0.90
Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Front Cell Neurosci (2014) 0.90
Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice. J Neurophysiol (2009) 0.89
Brain stem cells as the cell of origin in glioma. World J Stem Cells (2014) 0.88
Stem cells for brain repair in neonatal hypoxia-ischemia. Childs Nerv Syst (2013) 0.87
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons. PLoS One (2012) 0.87
Of mice and men: neurogenesis, cognition and Alzheimer's disease. Front Aging Neurosci (2013) 0.86
Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol Sci (2009) 0.85
Neural crest stem cells from dental tissues: a new hope for dental and neural regeneration. Stem Cells Int (2012) 0.85
Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Mol Vis (2009) 0.85
Neuronal Rac1 is required for learning-evoked neurogenesis. J Neurosci (2013) 0.84
Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. Stem Cells Dev (2010) 0.84
Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration? Clin Transl Med (2012) 0.82
Response of ependymal progenitors to spinal cord injury or enhanced physical activity in adult rat. Cell Mol Neurobiol (2009) 0.82
Neural stem cells: ready for therapeutic applications? Mol Cell Ther (2014) 0.80
Adult neural stem cells: The promise of the future. Neuropsychiatr Dis Treat (2007) 0.80
Overexpression of basic helix-loop-helix transcription factors enhances neuronal differentiation of fetal human neural progenitor cells in various ways. Stem Cells Dev (2011) 0.79
Neural progenitor cells from an adult patient with fragile X syndrome. BMC Med Genet (2005) 0.78
Adult human neural stem cell therapeutics: Current developmental status and prospect. World J Stem Cells (2015) 0.78
Healthy human CSF promotes glial differentiation of hESC-derived neural cells while retaining spontaneous activity in existing neuronal networks. Biol Open (2013) 0.78
Neural stem cell transplantation as a therapeutic approach for treating lysosomal storage diseases. Neurotherapeutics (2011) 0.77
Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming. PLoS One (2014) 0.76
Potential of adult neural stem cells for cellular therapy. Biologics (2007) 0.76
The human brain and its neural stem cells postmortem: from dead brains to live therapy. Int J Legal Med (2005) 0.76
Reflectin as a Material for Neural Stem Cell Growth. ACS Appl Mater Interfaces (2015) 0.75
Radiation-induced optic neuritis after pituitary adenoma radiosurgery in a patient with multiple sclerosis: case report. J Neurooncol (2008) 0.75
Potential of neural stem cells for the treatment of brain tumors. Clin Med Oncol (2008) 0.75
Adult neural stem cells: redefining the physio- and pathology of the CNS. Int J Biomed Sci (2008) 0.75
Glia-neuron interactions in neurological diseases: Testing non-cell autonomy in a dish. Brain Res (2016) 0.75
The dynamics of adult neurogenesis in human hippocampus. Neural Regen Res (2016) 0.75
A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater (2016) 0.75
Stem cell approaches in psychiatry--challenges and opportunities. Dialogues Clin Neurosci (2009) 0.75
Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders. J Comp Neurol (2014) 0.75
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Neurogenesis in the adult human hippocampus. Nat Med (1998) 17.53
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci (1999) 12.50
Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A (2000) 10.88
More hippocampal neurons in adult mice living in an enriched environment. Nature (1997) 10.06
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci (1996) 9.84
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A (1999) 8.83
Vascular niche for adult hippocampal neurogenesis. J Comp Neurol (2000) 7.19
Neural consequences of environmental enrichment. Nat Rev Neurosci (2000) 6.79
A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science (2009) 6.62
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci (1997) 4.92
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet (1997) 4.26
The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci (1997) 4.07
Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain (2005) 3.99
Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci (1998) 3.71
Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci (1999) 3.61
Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci (1997) 3.61
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci (2000) 3.40
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A (1997) 2.96
Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry (2000) 2.87
Regenerating the damaged central nervous system. Nature (2000) 2.85
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience (2004) 2.81
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci (1988) 2.73
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (1998) 2.72
Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc Natl Acad Sci U S A (2001) 2.48
FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci (1995) 2.45
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature (1987) 2.33
Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature (1996) 2.33
The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell (1996) 2.26
Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci (2000) 2.24
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci U S A (2010) 2.22
Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol (1999) 2.21
Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci (1998) 2.17
Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice. Hum Gene Ther (1997) 2.09
Can stem cells cross lineage boundaries? Nat Med (2001) 2.08
Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci (2000) 2.07
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci (1997) 2.07
Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci U S A (1993) 2.00
Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol (2001) 1.98
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol (1999) 1.79
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci U S A (1986) 1.77
The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer (2000) 1.74
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (1999) 1.73
Essential role of neocortical acetylcholine in spatial memory. Nature (1995) 1.68
Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci (2002) 1.67
Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol (1999) 1.64
Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci (1998) 1.62
Spatial learning and motor deficits in aged rats. Neurobiol Aging (1984) 1.60
An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron (1998) 1.58
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc Natl Acad Sci U S A (1999) 1.54
Hippocampal connections and spatial discrimination. Brain Res (1978) 1.54
Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol (1998) 1.51
FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron (2000) 1.50
Diagnostic value of ferritin and glycosylated ferritin in adult onset Still's disease. J Rheumatol (2001) 1.49
A packaging cell line for lentivirus vectors. J Virol (1999) 1.48
Sclerosteosis: neurogenetic and pathophysiologic analysis of an American kinship. Neurology (1983) 1.47
New nerve cells for the adult brain. Sci Am (1999) 1.47
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J Cell Biol (2001) 1.42
Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science (1988) 1.42
Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J Neurosci (1998) 1.42
Alzheimer's disease and spirochetes; a questionable relationship. Neuroreport (1993) 1.41
[Exercise alveolar hypoventilation in long-term survivors of bronchopulmonary dysplasia]. Rev Mal Respir (2008) 1.39
Lentiviral vectors: regulated gene expression. Mol Ther (2000) 1.39
Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn (2003) 1.38
[Epidemiology of end-stage kidney failure in the Ile-de-France: a prospective cooperative study in 1998]. Nephrologie (2000) 1.37
Vitamin D status during puberty in French healthy male adolescents. Osteoporos Int (1999) 1.36
Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev (2001) 1.35
Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proc Natl Acad Sci U S A (1996) 1.35
Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis (2010) 1.35
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci U S A (1994) 1.34
Activity-dependent regulation of neuronal plasticity and self repair. Prog Brain Res (2000) 1.29
Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol (1996) 1.26
Human cryptosporidiosis in the acquired immune deficiency syndrome. Arch Pathol Lab Med (1983) 1.26
FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. Exp Neurol (1997) 1.23
Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp Neurol (1999) 1.23
Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. Hippocampus (1999) 1.22
Neurogenesis in the adult hippocampus. Novartis Found Symp (2000) 1.18
Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci (1990) 1.17
Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol Aging (1992) 1.17
Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol (1994) 1.15
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A (1999) 1.14
Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry (2012) 1.14
Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior. Brain Res (1991) 1.11
An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther (2004) 1.10
Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats. J Neurosci (1984) 1.10
Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science (1987) 1.10
Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J Neurosci (1994) 1.09
Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience (1995) 1.07
Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurol Res (1985) 1.06
NGF improves spatial memory in aged rodents as a function of age. J Neurosci (1991) 1.06
Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther (1996) 1.05
Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration. J Neurosci (1995) 1.04
Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp Neurol (1991) 1.04
Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res (1989) 1.03
Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron (1991) 1.02