Published in N Engl J Med on May 03, 2001
Qingdao Diabetes Prevention Project (QDDPP) | NCT01053195
Diabetes Prevention Program Pilot Study (DPP) | NCT00729079
Prevention of Diabetes and Hypertension (PHIDIAS) | NCT00456963
Rosiglitazone to Reverse Metabolic Defects in Diabetes | NCT00094796
Optimal Metabolic Health Through Continuous Glucose Monitoring (CGM) | NCT04920058
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care (2009) 26.77
Standards of medical care in diabetes--2013. Diabetes Care (2013) 24.85
Standards of medical care in diabetes--2010. Diabetes Care (2010) 24.28
Standards of medical care in diabetes--2011. Diabetes Care (2011) 21.94
Standards of medical care in diabetes--2012. Diabetes Care (2012) 20.66
Health benefits of physical activity: the evidence. CMAJ (2006) 19.45
Standards of medical care in diabetes--2009. Diabetes Care (2009) 15.78
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet (2009) 15.00
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care (2002) 11.65
The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med (2003) 10.84
JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart (2005) 9.79
2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ (2007) 9.10
The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring) (2006) 8.25
Exercise and cardiovascular risk reduction: time to update the rationale for exercise? J Appl Physiol (1985) (2008) 8.17
Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care (2006) 7.09
Diabetes and cancer: a consensus report. Diabetes Care (2010) 6.71
The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance. Ann Intern Med (2005) 6.63
Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care (2011) 6.48
Prediabetes: a high-risk state for diabetes development. Lancet (2012) 6.42
Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ (2010) 6.05
Utility of hemoglobin A1c in predicting diabetes risk. J Gen Intern Med (2004) 5.97
Achieving weight and activity goals among diabetes prevention program lifestyle participants. Obes Res (2004) 5.74
Weight loss to treat urinary incontinence in overweight and obese women. N Engl J Med (2009) 5.58
A behavioral weight-loss intervention in persons with serious mental illness. N Engl J Med (2013) 5.52
Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry (2011) 5.46
Changing habits to delay diabetes. N Engl J Med (2001) 5.30
Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA (2012) 5.15
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation (2013) 5.02
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet (2009) 4.96
Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol (2012) 4.87
Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes (2005) 4.81
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet (2016) 4.80
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet (2012) 4.33
A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults. Int J Behav Nutr Phys Act (2010) 4.05
Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care (2010) 3.98
Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening? BMJ (2002) 3.96
Weight loss during the intensive intervention phase of the weight-loss maintenance trial. Am J Prev Med (2008) 3.79
The reality of type 2 diabetes prevention. Diabetes Care (2014) 3.74
Translating the Diabetes Prevention Program lifestyle intervention for weight loss into primary care: a randomized trial. JAMA Intern Med (2013) 3.69
Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore. BMJ (2009) 3.68
Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults. Am J Epidemiol (2010) 3.64
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism (2012) 3.61
Combined impact of lifestyle factors on mortality: prospective cohort study in US women. BMJ (2008) 3.58
Systematic review of reviews of intervention components associated with increased effectiveness in dietary and physical activity interventions. BMC Public Health (2011) 3.55
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr (2012) 3.48
A comprehensive review on metabolic syndrome. Cardiol Res Pract (2014) 3.47
Exercise on prescription for women aged 40-74 recruited through primary care: two year randomised controlled trial. BMJ (2008) 3.43
Within-trial cost-effectiveness of lifestyle intervention or metformin for the primary prevention of type 2 diabetes. Diabetes Care (2003) 3.37
Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ (2013) 3.25
Evaluation of the Counterweight Programme for obesity management in primary care: a starting point for continuous improvement. Br J Gen Pract (2008) 3.16
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia (2007) 3.13
The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS. Diabetes Care (2012) 3.12
Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among Persons at Increased Risk: A Systematic Review for the Community Preventive Services Task Force. Ann Intern Med (2015) 3.11
The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010) 3.09
Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol (2012) 3.09
Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care (2010) 3.07
The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation. Diabetologia (2009) 3.05
Progression from newly acquired impaired fasting glusose to type 2 diabetes. Diabetes Care (2007) 2.95
Activation of the peripheral endocannabinoid system in human obesity. Diabetes (2005) 2.90
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A (2006) 2.88
Development and validation of a patient self-assessment score for diabetes risk. Ann Intern Med (2009) 2.85
Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation (2008) 2.85
Prevalence of diabetes mellitus in a Saudi community. Ann Saudi Med (2011) 2.83
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes (2005) 2.80
The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol (2011) 2.77
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care (2011) 2.75
Human genetics illuminates the paths to metabolic disease. Nature (2009) 2.74
Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study. Arch Intern Med (2009) 2.72
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet (2013) 2.66
The STRIDE weight loss and lifestyle intervention for individuals taking antipsychotic medications: a randomized trial. Am J Psychiatry (2014) 2.65
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr (2006) 2.57
The impact of obesity on drug prescribing in primary care. Br J Gen Pract (2005) 2.56
Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program. Am J Clin Nutr (2008) 2.55
Border health strategic initiative: overview and introduction to a community-based model for diabetes prevention and control. Prev Chronic Dis (2004) 2.54
Prevention of type 2 diabetes by lifestyle intervention in an Australian primary health care setting: Greater Green Triangle (GGT) Diabetes Prevention Project. BMC Public Health (2007) 2.53
Risk of development of diabetes mellitus after diagnosis of gestational diabetes. CMAJ (2008) 2.52
Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes (2014) 2.52
The role of physical activity in the management of impaired glucose tolerance: a systematic review. Diabetologia (2007) 2.51
Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D). Diabetes Care (2010) 2.50
The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk. J Physiol (2009) 2.47
The increasing prevalence of diabetes in pregnancy. Obstet Gynecol Clin North Am (2007) 2.45
Longitudinal Associations Between Neighborhood Physical and Social Environments and Incident Type 2 Diabetes Mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA). JAMA Intern Med (2015) 2.45
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab (2010) 2.40
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
Education, income, occupation, and the 34-year incidence (1965-99) of Type 2 diabetes in the Alameda County Study. Int J Epidemiol (2005) 2.37
Prevention and cure of type 2 diabetes. BMJ (2002) 2.35
The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci (2006) 2.35
A1C level and future risk of diabetes: a systematic review. Diabetes Care (2010) 2.35
The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 2.27
Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ (2005) 2.24
Ecological approaches to self-management: the case of diabetes. Am J Public Health (2005) 2.23
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med (1998) 25.66
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet (2006) 15.32
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet (2005) 13.18
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet (2006) 11.64
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet (1998) 8.02
Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol (2002) 5.97
The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care (2003) 5.48
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J (2005) 5.40
Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl (1977) 4.82
Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand (1981) 4.53
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol (1996) 3.77
Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia (2001) 3.73
Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ (1997) 3.63
Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg (1969) 3.35
A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res (2010) 3.15
Diabetes and atherosclerosis: an epidemiologic view. Diabetes Metab Rev (1987) 2.88
Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study. BMJ (2001) 2.79
Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ (1999) 2.78
Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis (2004) 2.77
NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes (1994) 2.67
Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia (2009) 2.63
Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia (1999) 2.51
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet (2000) 2.50
Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland. Neurology (1995) 2.44
Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose. Eur Heart J (2002) 2.31
Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. N Engl J Med (1995) 2.29
Diet, nutrition and the prevention of type 2 diabetes. Public Health Nutr (2004) 2.25
Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int (2011) 2.19
Ten year mortality and causes of death in patients with rheumatoid arthritis. Br Med J (Clin Res Ed) (1985) 2.10
Is body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational studies. Int J Obes (Lond) (2009) 2.05
Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS). Diabetologia (2012) 1.99
Take action to prevent diabetes--the IMAGE toolkit for the prevention of type 2 diabetes in Europe. Horm Metab Res (2010) 1.99
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Circulation (1998) 1.98
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. J Clin Invest (2000) 1.97
Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. Stroke (1996) 1.97
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia (2007) 1.97
Meta-analysis of genome-wide association studies for personality. Mol Psychiatry (2010) 1.96
Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy. Arterioscler Thromb Vasc Biol (1999) 1.95
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet (2000) 1.93
Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporos Int (2001) 1.91
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke (1998) 1.88
Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland. Eur Heart J (1996) 1.82
Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group. Lancet (1992) 1.80
Occupational, commuting, and leisure-time physical activity in relation to risk for Type 2 diabetes in middle-aged Finnish men and women. Diabetologia (2003) 1.79
Risk factors predicting lower extremity amputations in patients with NIDDM. Diabetes Care (1996) 1.78
Early androgenetic alopecia as a marker of insulin resistance. Lancet (2000) 1.71
Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study--secondary analysis of the randomized trial. PLoS One (2009) 1.68
Birth size, adult body composition and muscle strength in later life. Int J Obes (Lond) (2007) 1.66
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance. Diabetologia (2010) 1.64
Association of neck circumference with insulin resistance-related factors. Int J Obes Relat Metab Disord (2002) 1.64
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation (1999) 1.64
Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes (1997) 1.64
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia (1998) 1.63
Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol (2000) 1.62
Reduction in sudden deaths by a multifactorial intervention programme after acute myocardial infarction. Lancet (1979) 1.60
European stroke prevention study: effectiveness of antiplatelet therapy in diabetic patients in secondary prevention of stroke. Stroke (1992) 1.59
Osseointegrated titanium implants in the temporal bone. A clinical study on bone-anchored hearing aids. Am J Otol (1981) 1.58
Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data. Diabetologia (2004) 1.57
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort. Diabetes Care (2004) 1.54
Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects. Eur J Clin Nutr (2010) 1.54
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet (2000) 1.53
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. Diabetologia (2008) 1.53
Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes (1996) 1.52
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet (1998) 1.52
Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish women. Bone (1996) 1.51
Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study. Diabetes Care (2008) 1.51
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study. Diabetologia (2007) 1.50
Good continuity of care may improve quality of life in Type 2 diabetes. Diabetes Res Clin Pract (2001) 1.50
Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men. J Clin Endocrinol Metab (1996) 1.49
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease. Atherosclerosis (2001) 1.49
Leptin concentrations, sex hormones, and cortisol in nondiabetic men. J Clin Endocrinol Metab (1997) 1.49
The European perspective of type 2 diabetes prevention: diabetes in Europe--prevention using lifestyle, physical activity and nutritional intervention (DE-PLAN) project. Exp Clin Endocrinol Diabetes (2008) 1.49
Oxidised LDL and progression of atherosclerosis. Lancet (1992) 1.49
Use of primary health services in sparsely populated country districts by patients with musculoskeletal symptoms: consultations with a physician. J Epidemiol Community Health (1993) 1.48
Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. Am J Clin Nutr (1998) 1.47
Impairment of diastolic function in middle-aged type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease. Diabetologia (1988) 1.46
Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study. Diabetes (2003) 1.46
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Hum Gene Ther (1998) 1.45
Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology (2006) 1.45