PubRank

L M Obeid

Author PubWeight™ 65.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci 1995 2.28
2 Role for ceramide in cell cycle arrest. J Biol Chem 1995 1.83
3 Role of ceramide in cellular senescence. J Biol Chem 1995 1.74
4 Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 1993 1.63
5 Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A 1996 1.53
6 Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem 2000 1.52
7 Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem 1998 1.52
8 Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem 1997 1.49
9 Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J 2001 1.45
10 Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today 1995 1.40
11 Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 1994 1.40
12 Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem 2000 1.39
13 Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem 2001 1.39
14 Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem 1997 1.33
15 Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem 1997 1.29
16 The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J 1999 1.27
17 Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem 1993 1.27
18 Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem 2000 1.26
19 Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev 1994 1.25
20 Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A 1995 1.24
21 Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem 1993 1.23
22 Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem 2001 1.19
23 Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem 2001 1.17
24 Ceramide inactivates cellular protein kinase Calpha. J Biol Chem 1996 1.16
25 Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med 1997 1.15
26 Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem 2001 1.12
27 p53-dependent ceramide response to genotoxic stress. J Clin Invest 1998 1.11
28 Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol 1999 1.10
29 Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem 2001 1.10
30 prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J 1996 1.09
31 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. J Biol Chem 1991 0.98
32 Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection. J Biol Chem 1998 0.97
33 Phospholipase D in cellular senescence. Biochim Biophys Acta 1999 0.95
34 Ceramide inhibits phospholipase D in a cell-free system. J Biol Chem 1996 0.94
35 Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene 2011 0.94
36 Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. J Biol Chem 1994 0.94
37 Regulation of cyclin-dependent kinase 2 activity by ceramide. Exp Cell Res 2000 0.94
38 Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol 2000 0.93
39 Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ 1997 0.92
40 Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem 1997 0.92
41 Ceramide and the eukaryotic stress response. Biochem Soc Trans 1997 0.91
42 Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem 2000 0.90
43 Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci 1996 0.89
44 Protein kinase C isoenzymes: regulation and function. Cancer Surv 1996 0.86
45 Regulation of membrane release in apoptosis. Biochem J 1998 0.86
46 Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ 1994 0.86
47 Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. Biochem J 1998 0.84
48 The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res 1993 0.84
49 Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol 1997 0.83
50 TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. FEBS Lett 2001 0.83
51 Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta 1997 0.82
52 Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. J Biol Chem 1993 0.82
53 Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J 1995 0.81
54 Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol 1997 0.81
55 Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. Methods Enzymol 2000 0.80
56 Use of yeast as a model system for studies of sphingolipid metabolism and signaling. Methods Enzymol 2000 0.78
57 Ceramide and the regulation of apoptosis and the stress response. Trends Cardiovasc Med 1996 0.77
58 A disrupted homologue of the human CLN3 or juvenile neuronal ceroid lipofuscinosis gene in Saccharomyces cerevisiae: a model to study Batten disease. Cell Mol Neurobiol 1999 0.76
59 Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity. Anal Biochem 2001 0.76
60 Isolated atlantoaxial subluxation as the presenting manifestation of inflammatory bowel disease. Am J Med 1986 0.75
61 A novel assay for apoptotic body formation and membrane release during apoptosis. Cell Death Differ 1999 0.75