Published in Mol Biol Cell on May 01, 2001
Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins. EMBO Rep (2003) 1.97
Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I. Mol Cell Biol (2007) 1.82
The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins. J Cell Biol (2006) 1.35
A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Plant Physiol (2004) 1.27
Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol (2007) 1.22
Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell (2007) 1.22
Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa. Mol Biol Cell (2010) 0.97
Lateral release of proteins from the TOM complex into the outer membrane of mitochondria. EMBO J (2011) 0.95
Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40. Sci Rep (2011) 0.90
Alternative splicing gives rise to different isoforms of the Neurospora crassa Tob55 protein that vary in their ability to insert beta-barrel proteins into the outer mitochondrial membrane. Genetics (2007) 0.84
Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import. Mol Biol Cell (2012) 0.83
Characterization of the targeting signal in mitochondrial β-barrel proteins. Nat Commun (2016) 0.78
Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix. Mol Cell Biol (2014) 0.78
The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer's disease. Biochim Biophys Acta (2017) 0.75
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem (1991) 12.68
Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis. Anal Biochem (1994) 7.30
Protein import into mitochondria. Annu Rev Biochem (1997) 6.82
The protein import system of mitochondria. J Biol Chem (1996) 3.96
Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature (1998) 3.77
Mitochondrial preprotein translocase. Annu Rev Cell Dev Biol (1997) 3.68
Identification and characterization of recombinant plasmids carrying the complete qa gene cluster from Neurospora crassa including the qa-1+ regulatory gene. Proc Natl Acad Sci U S A (1981) 3.07
General method for cloning Neurospora crassa nuclear genes by complementation of mutants. Mol Cell Biol (1985) 2.85
The preprotein translocation channel of the outer membrane of mitochondria. Cell (1998) 2.65
Classical mutagenesis techniques. Methods Enzymol (1991) 2.44
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature (1989) 2.18
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (1990) 1.90
Import of proteins into mitochondria. Annu Rev Genet (1991) 1.84
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. EMBO J (1996) 1.74
The TOM core complex: the general protein import pore of the outer membrane of mitochondria. J Cell Biol (1999) 1.73
Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71
A signal-anchor sequence selective for the mitochondrial outer membrane. J Cell Biol (1992) 1.68
Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol (2000) 1.57
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria. J Cell Biol (1993) 1.55
Biogenesis of Tom40, core component of the TOM complex of mitochondria. J Cell Biol (1999) 1.53
Mitochondrial protein import. Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence. J Biol Chem (1997) 1.52
An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc Natl Acad Sci U S A (1999) 1.45
How membrane proteins travel across the mitochondrial intermembrane space. Trends Biochem Sci (1999) 1.41
Import and insertion of proteins into the mitochondrial outer membrane. Eur J Biochem (1995) 1.36
Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. EMBO J (1993) 1.27
The isolated complex of the translocase of the outer membrane of mitochondria. Characterization of the cation-selective and voltage-gated preprotein-conducting pore. J Biol Chem (1998) 1.24
Topogenesis of inner membrane proteins of mitochondria. Trends Biochem Sci (1996) 1.22
Detection of likely transmembrane beta strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler. J Bioenerg Biomembr (1996) 1.21
Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Mol Cell Biol (1998) 1.19
Biogenesis of mitochondrial proteins. Curr Opin Cell Biol (1996) 1.13
Biogenesis of the mitochondrial receptor complex. Two receptors are required for binding of MOM38 to the outer membrane surface. J Biol Chem (1993) 1.12
The effects of chloroplast lipids on the stability of liposomes during freezing and drying. Biochim Biophys Acta (1998) 1.08
Import of proteins into mitochondria and chloroplasts. Trends Cell Biol (1997) 1.03
An import signal in the cytosolic domain of the Neurospora mitochondrial outer membrane protein TOM22. J Biol Chem (1998) 1.00
Inactivation of the Neurospora crassa gene encoding the mitochondrial protein import receptor MOM19 by the technique of "sheltered RIP". Genetics (1994) 0.96
Biogenesis of ISP6, a small carboxyl-terminal anchored protein of the receptor complex of the mitochondrial outer membrane. J Biol Chem (1995) 0.95
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate. Nature (1991) 6.20
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature (1989) 5.19
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12
Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature (1989) 4.57
DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage. EMBO J (1993) 4.32
Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem (1998) 3.96
Mitochondrial protein import. Biochim Biophys Acta (1989) 3.66
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem Sci (1994) 3.65
Transport of proteins into mitochondria: translocational intermediates spanning contact sites between outer and inner membranes. Cell (1985) 3.55
Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast (2000) 3.52
The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. J Clin Invest (1972) 3.43
The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE. Proc Natl Acad Sci U S A (1994) 3.33
The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science (1994) 3.26
Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature (1994) 3.08
Protein sorting to mitochondria: evolutionary conservations of folding and assembly. Science (1990) 3.07
The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell (1996) 2.80
Requirement of a membrane potential for the posttranslational transfer of proteins into mitochondria. Eur J Biochem (1982) 2.71
Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. EMBO J (1998) 2.67
The preprotein translocation channel of the outer membrane of mitochondria. Cell (1998) 2.65
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Nucleotide sequence of ilvGEDA operon attenuator region of Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.61
Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell (1987) 2.61
Mitochondrial protein import: identification of processing peptidase and of PEP, a processing enhancing protein. Cell (1988) 2.57
Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem Sci (1994) 2.44
Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms. J Biol Chem (1988) 2.43
MITOP, the mitochondrial proteome database: 2000 update. Nucleic Acids Res (2000) 2.43
Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae. Nature (1990) 2.37
Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Mol Cell Biol (1999) 2.34
Transport of F1-ATPase subunit beta into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett (1986) 2.33
Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60. Annu Rev Biophys Biomol Struct (1992) 2.31
The mitochondrial protein import apparatus. Annu Rev Biochem (1990) 2.31
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding. Nature (1993) 2.30
Successive translocation into and out of the mitochondrial matrix: targeting of proteins to the intermembrane space by a bipartite signal peptide. Cell (1987) 2.24
Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase. Cell (1986) 2.21
Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J (1985) 2.19
MOM19, an import receptor for mitochondrial precursor proteins. Cell (1989) 2.18
Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding. Cell (1994) 2.12
Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature (1996) 2.03
Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell (1996) 2.02
Distinct steps in the import of ADP/ATP carrier into mitochondria. J Biol Chem (1987) 2.02
Assembly of cytochrome c. Apocytochrome c is bound to specific sites on mitochondria before its conversion to holocytochrome c. Eur J Biochem (1981) 1.97
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell (1992) 1.96
A mitochondrial import receptor for the ADP/ATP carrier. Cell (1990) 1.95
The cytochrome bc1 and cytochrome c oxidase complexes associate to form a single supracomplex in yeast mitochondria. J Biol Chem (2000) 1.93
Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA. EMBO J (2001) 1.91
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (1990) 1.90
ATP synthase of yeast mitochondria. Isolation of subunit j and disruption of the ATP18 gene. J Biol Chem (1999) 1.87
Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites. J Cell Biol (1989) 1.84
Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature (1998) 1.81
Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. EMBO J (1994) 1.80
Oxa1p, an essential component of the N-tail protein export machinery in mitochondria. Proc Natl Acad Sci U S A (1998) 1.76
Cell-free synthesis of the mitochondrial ADP/ATP carrier protein of Neurospora crassa. Eur J Biochem (1979) 1.75
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. EMBO J (1996) 1.74
A dynamic model of the mitochondrial protein import machinery. Cell (1992) 1.74
Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface. Mol Cell (2000) 1.73
The processing peptidase of yeast mitochondria: the two co-operating components MPP and PEP are structurally related. EMBO J (1988) 1.73
Processing peptidase of Neurospora mitochondria. Two-step cleavage of imported ATPase subunit 9. Eur J Biochem (1984) 1.73
The TOM core complex: the general protein import pore of the outer membrane of mitochondria. J Cell Biol (1999) 1.73
Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides. Proc Natl Acad Sci U S A (1993) 1.72
Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol (1990) 1.72
Mechanism of Renin Tachyphylaxis--Restoration of Responsiveness by Tetraethyl Ammonium Ion. Science (1947) 1.71
Mitochondrial molecular chaperones: their role in protein translocation. Trends Biochem Sci (1994) 1.70
Proteinaceous receptors for the import of mitochondrial precursor proteins. J Biol Chem (1984) 1.68
Tim23 links the inner and outer mitochondrial membranes. Cell (2000) 1.68
The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell (1993) 1.67
Mitochondrial protein import: reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding. Cell (1995) 1.66
Anterior transperitoneal lumbar fusion. J Bone Joint Surg Br (1971) 1.65
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J Cell Biol (2001) 1.65
Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites. EMBO J (1987) 1.63
The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system. Cell (1995) 1.63
Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease. Nature (1999) 1.62
Oxa1p mediates the export of the N- and C-termini of pCoxII from the mitochondrial matrix to the intermembrane space. FEBS Lett (1997) 1.62
Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett (1990) 1.60
Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J Cell Biol (2001) 1.60
Sequence and structure of the dopa decarboxylase gene of Drosophila: evidence for novel RNA splicing variants. EMBO J (1986) 1.60
Import into mitochondria, folding and retrograde movement of fumarase in yeast. J Biol Chem (1998) 1.59
Protein transport into mitochondria. Curr Opin Microbiol (2000) 1.59
Biogenesis of cytochrome c in Neurospora crassa. Synthesis of apocytochrome c, transfer to mitochondria and conversion to Holocytochrome c. Eur J Biochem (1978) 1.58
The DNA sequence and genetic organization of a Neurospora mitochondrial plasmid suggest a relationship to introns and mobile elements. Cell (1984) 1.57
Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol (2000) 1.57
Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature (1992) 1.56
The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. EMBO J (1998) 1.56
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria. J Cell Biol (1993) 1.55
Why drugs fail--a study on side effects in new chemical entities. Curr Pharm Des (2005) 1.54
Biogenesis of Tom40, core component of the TOM complex of mitochondria. J Cell Biol (1999) 1.53
Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science (2001) 1.53
Insertion into the mitochondrial inner membrane of a polytopic protein, the nuclear-encoded Oxa1p. EMBO J (1997) 1.53
Receptor sites involved in posttranslational transport of apocytochrome c into mitochondria: specificity, affinity, and number of sites. Proc Natl Acad Sci U S A (1983) 1.53