Mitochondrial preprotein translocase.

The yeast proteome database (YPD) and Caenorhabditis elegans proteome database (WormPD): comprehensive resources for the organization and comparison of model organism protein information. Nucleic Acids Res (2000) 17.68

Protein import and routing systems of chloroplasts. Plant Cell (1999) 2.84

Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71

Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria. Mol Biol Cell (1999) 1.69

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J (2000) 1.69

Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J Cell Biol (2001) 1.65

Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep (2000) 1.64

Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc Natl Acad Sci U S A (2003) 1.63

Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53

An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc Natl Acad Sci U S A (1999) 1.45

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J Cell Biol (1999) 1.41

Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol Biol Cell (2000) 1.39

Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane. Proc Natl Acad Sci U S A (1999) 1.29

A stromal Hsp100 protein is required for normal chloroplast development and function in Arabidopsis. Plant Physiol (2004) 1.29

A molecular-genetic study of the Arabidopsis Toc75 gene family. Plant Physiol (2005) 1.25

Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell (1999) 1.25

The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation. EMBO J (2001) 1.20

Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import. Mol Biol Cell (2006) 1.20

Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. J Cell Biol (2001) 1.17

Competition of spontaneous protein folding and mitochondrial import causes dual subcellular location of major adenylate kinase. Mol Biol Cell (2002) 1.16

Role of the mitochondrial Hsp70s, Ssc1 and Ssq1, in the maturation of Yfh1. Mol Cell Biol (2000) 1.12

Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. Mol Cell Biol (1999) 1.10

Presence of a member of the mitochondrial carrier family in hydrogenosomes: conservation of membrane-targeting pathways between hydrogenosomes and mitochondria. Mol Cell Biol (2000) 1.10

The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem (2012) 1.08

tRNAs and proteins are imported into mitochondria of Trypanosoma brucei by two distinct mechanisms. Mol Biol Cell (1999) 1.02

Targeting and insertion of C-terminally anchored proteins to the mitochondrial outer membrane is specific and saturable but does not strictly require ATP or molecular chaperones. Biochem J (2000) 1.02

Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role. Mol Cell Biol (2000) 1.01

Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria. Mol Biol Cell (2001) 0.99

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation. J Cell Biol (1999) 0.98

Two distinct mechanisms drive protein translocation across the mitochondrial outer membrane in the late step of the cytochrome b(2) import pathway. Proc Natl Acad Sci U S A (1999) 0.98

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins. Mol Cell Biol (2001) 0.98

Role of the negative charges in the cytosolic domain of TOM22 in the import of precursor proteins into mitochondria. Mol Cell Biol (1998) 0.94

Membrane association of greasy grouper nervous necrosis virus protein A and characterization of its mitochondrial localization targeting signal. J Virol (2004) 0.91

Mitochondria and reactive oxygen species: physiology and pathophysiology. Int J Mol Sci (2013) 0.89

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria. J Bacteriol (2006) 0.84

Chemical cleavage of the overexpressed mitochondrial F1beta precursor with CNBr: a new strategy to construct an import-competent preprotein. Biochem J (1999) 0.83

Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron (2016) 0.81

Genetic analysis of the Drosophila 63F early puff. Characterization of mutations in E63-1 and maggie, a putative Tom22. Genetics (2000) 0.80

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase. Biochem J (2005) 0.79

Signals and receptors--the translocation machinery on the mitochondrial surface. J Bioenerg Biomembr (2000) 0.79

TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. Neuropsychopharmacology (2014) 0.78

Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62

The heat-shock proteins. Annu Rev Genet (1988) 22.28

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature (1988) 11.00

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci U S A (1984) 7.20

The heat shock response. CRC Crit Rev Biochem (1985) 6.82

Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions. Cell (1980) 6.17

Consensus sequence for Escherichia coli heat shock gene promoters. Proc Natl Acad Sci U S A (1985) 6.04

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin. Proc Natl Acad Sci U S A (1982) 5.39

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis. Cell (1992) 4.39

Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila. Mol Cell Biol (1982) 4.26

Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth. Cell (1984) 3.83

Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae. Mol Cell Biol (1987) 3.75

Heat-shock proteins as molecular chaperones. Eur J Biochem (1994) 3.26

Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock. Proc Natl Acad Sci U S A (1982) 3.23

Sequence organization of two recombinant plasmids containing genes for the major heat shock-induced protein of D. melanogaster. Cell (1979) 3.21

Primary sequence of the 5' flanking regions of the Drosophila heat shock genes in chromosome subdivision 67B. Nucleic Acids Res (1981) 3.21

Molecular evolution of the HSP70 multigene family. J Mol Evol (1994) 3.00

Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature (1997) 2.88

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61

Effect of cycloheximide on RNA metabolism early in productive infection with adenovirus 2. J Virol (1974) 2.56

Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Mol Cell Biol (1996) 2.53

Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.52

Yeast Hsp70 RNA levels vary in response to the physiological status of the cell. J Bacteriol (1989) 2.51

Functional specificity among Hsp70 molecular chaperones. Science (1997) 2.45

Differential regulation of the 70K heat shock gene and related genes in Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.45

Getting newly synthesized proteins into shape. Cell (2000) 2.45

Expression of Drosophila heat-shock cognate genes during heat shock and development. Dev Biol (1983) 2.40

Primer extension analysis of RNA. Methods Enzymol (1989) 2.38

Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutation. J Bacteriol (1990) 2.30

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28

The role of Sis1 in the maintenance of the [RNQ+] prion. EMBO J (2001) 2.26

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.25

Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures. Mol Cell Biol (1985) 2.24

The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex. EMBO J (1998) 2.17

Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.14

SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth. Proc Natl Acad Sci U S A (1987) 2.10

Ancient heat shock gene is dispensable. J Bacteriol (1988) 2.01

How do polypeptides cross the mitochondrial membranes? Cell (1990) 1.91

The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell (1999) 1.91

Protein folding in vivo: unraveling complex pathways. Cell (1997) 1.90

Multiple actin-related sequences in the Drosophila melanogaster genome. Cell (1980) 1.86

Zuotin, a ribosome-associated DnaJ molecular chaperone. EMBO J (1998) 1.84

Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.82

Analysis of early adenovirus 2 RNA using Eco R-R1 viral DNA fragments. J Virol (1975) 1.80

Transcriptional regulation of SSA3, an HSP70 gene from Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.77

Four Drosophila heat shock genes at 67B: characterization of recombinant plasmids. Nucleic Acids Res (1980) 1.76

Two clusters of genes for major chorion proteins of Drosophila melanogaster. Cell (1980) 1.75

Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol (1993) 1.73

Expression and localization of Drosophila melanogaster hsp70 cognate proteins. Mol Cell Biol (1986) 1.72

Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71

Mitochondrial molecular chaperones: their role in protein translocation. Trends Biochem Sci (1994) 1.70

Positive and negative regulation of basal expression of a yeast HSP70 gene. Mol Cell Biol (1989) 1.68

Genetic evidence for a functional relationship between Hsp104 and Hsp70. J Bacteriol (1993) 1.68

Regulation of a yeast HSP70 gene by a cAMP responsive transcriptional control element. EMBO J (1990) 1.67

The glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1. Mol Cell Biol (1999) 1.65

Genes for three Drosophila heat-shock-induced proteins at a single locus. Proc Natl Acad Sci U S A (1980) 1.59

Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature (1999) 1.56

A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation. Proc Natl Acad Sci U S A (1994) 1.51

Mitochondrial Hsp70 Ssc1: role in protein folding. J Biol Chem (2000) 1.50

The dissociation of ATP from hsp70 of Saccharomyces cerevisiae is stimulated by both Ydj1p and peptide substrates. J Biol Chem (1995) 1.50

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA. J Cell Biol (1994) 1.49

An essential role for the substrate-binding region of Hsp40s in Saccharomyces cerevisiae. J Cell Biol (2001) 1.48

Localization of adenovirus 2 messenger RNA's to segments of the viral genome defined by endonuclease R-R1. Proc Natl Acad Sci U S A (1974) 1.47

Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae. J Biol Chem (1990) 1.44

Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. J Biol Chem (1994) 1.42

Nuclear transcripts larger than the cytoplasmic mRNAs are specified by segments of the adenovirus genome coding for early functions. Cell (1976) 1.40

Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2001) 1.37

Two classes of cytoplasmic viral RNA synthesized early in productive infection with adenovirus 2. J Virol (1974) 1.37

The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences. Mol Cell Biol (1997) 1.33

Mge1 functions as a nucleotide release factor for Ssc1, a mitochondrial Hsp70 of Saccharomyces cerevisiae. J Mol Biol (1997) 1.31

Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix. FEBS Lett (1990) 1.31

Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes. Mol Cell Biol (1994) 1.27

SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum. Mol Cell Biol (1996) 1.27

Intragenic suppressors of Hsp70 mutants: interplay between the ATPase- and peptide-binding domains. Proc Natl Acad Sci U S A (1999) 1.27

The protein import machinery of the mitochondrial inner membrane. Trends Biochem Sci (1994) 1.26

The SSA1 and SSA2 genes of the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1989) 1.24

The yeast hsp70 homologue Ssa is required for translation and interacts with Sis1 and Pab1 on translating ribosomes. J Biol Chem (2001) 1.19

Mitochondrial import of subunit Va of cytochrome c oxidase characterized with yeast mutants. J Biol Chem (1995) 1.18

The biochemical properties of the ATPase activity of a 70-kDa heat shock protein (Hsp70) are governed by the C-terminal domains. Proc Natl Acad Sci U S A (1998) 1.18

Divergent functional properties of the ribosome-associated molecular chaperone Ssb compared with other Hsp70s. Mol Biol Cell (2001) 1.17

Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins. Proc Natl Acad Sci U S A (1998) 1.17

Mitochondrial receptor complex from Neurospora crassa and Saccharomyces cerevisiae. Methods Enzymol (1995) 1.16

Acquired palsy of the oculomotor, trochlear and abducens nerves. Eye (Lond) (1996) 1.15

A heat shock transcription factor with reduced activity suppresses a yeast HSP70 mutant. Mol Cell Biol (1995) 1.15

The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins. Mol Cell Biol (1995) 1.15

Inducing and assaying heat-shock response in Saccharomyces cerevisiae. Methods Enzymol (1991) 1.14

A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast. Mol Cell Biol (2000) 1.13

Essential roles of 70kDa heat inducible proteins. Bioessays (1990) 1.13

RNA transcription in cultures productively infected with adenovirus 2. Cold Spring Harb Symp Quant Biol (1975) 1.12

Role of the mitochondrial Hsp70s, Ssc1 and Ssq1, in the maturation of Yfh1. Mol Cell Biol (2000) 1.12

Identification of early adenovirus type 2 RNA species transcribed from the left-hand end of the genome. J Virol (1975) 1.11

Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane. Biochem J (1998) 1.09

Uncoating of coated vesicles by yeast hsp70 proteins. J Biol Chem (1991) 1.08

Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria. Mol Cell Biol (1997) 1.06

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane. EMBO J (1997) 1.06

Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins. Mol Cell Biol (1995) 1.05

Transcriptional regulation of a yeast HSP70 gene by heat shock factor and an upstream repression site-binding factor. Genes Dev (1991) 1.05

Rapid quantitation of individual RNA species in a complex population. Nucleic Acids Res (1979) 1.05

A nuclear export signal prevents Saccharomyces cerevisiae Hsp70 Ssb1p from stimulating nuclear localization signal-directed nuclear transport. J Biol Chem (1999) 1.04