Published in J Clin Pharmacol on May 01, 2001
Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs (2008) 2.62
Using a Systems Pharmacology Approach to Study the Effect of Statins on the Early Stage of Atherosclerosis in Humans. CPT Pharmacometrics Syst Pharmacol (2014) 0.84
Is cytochrome modulation the new frontier for decreasing the risk of cataract? Indian J Pharmacol (2009) 0.80
Simvastatin inhibits protein isoprenylation in the brain. Neuroscience (2016) 0.75
Simvastatin attenuates TNF-alpha-induced growth inhibition and apoptosis in murine osteoblastic MC3T3-E1 cells. Inflamm Res (2010) 0.75
Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol (1999) 7.72
Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology (1999) 6.03
Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature (1999) 5.77
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer. Proc Natl Acad Sci U S A (1987) 4.13
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A (1997) 4.07
Biomarker identification by feature wrappers. Genome Res (2001) 3.93
Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol (2001) 3.86
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron (2000) 3.73
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol (1994) 3.66
G-protein signaling through tubby proteins. Science (2001) 3.59
CDKN2A mutations in multiple primary melanomas. N Engl J Med (1998) 3.52
Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast. Genes Dev (1997) 3.47
Pharmacokinetics and tolerance of N-formimidoyl thienamycin (MK0787) in humans. Antimicrob Agents Chemother (1983) 3.46
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell (2000) 3.36
Rapid elimination of low-copy DNA sequences in polyploid wheat: a possible mechanism for differentiation of homoeologous chromosomes. Genetics (1997) 3.28
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet (2000) 3.25
Refractive Error Study in Children: sampling and measurement methods for a multi-country survey. Am J Ophthalmol (2000) 3.22
Fas-induced caspase denitrosylation. Science (1999) 3.21
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity (1998) 2.95
Central melanocortin receptors regulate insulin action. J Clin Invest (2001) 2.83
Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial. Ann Intern Med (2000) 2.82
Rapid genomic changes in newly synthesized amphiploids of Triticum and Aegilops. II. Changes in low-copy coding DNA sequences. Genome (1998) 2.81
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science (1990) 2.80
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev (1998) 2.76
Presence of depressive symptoms during early pregnancy and the risk of preterm delivery: a prospective cohort study. Hum Reprod (2008) 2.68
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res (1993) 2.65
Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol (2012) 2.63
Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry (1998) 2.62
The practice of neurology, 2000-2010: report of the AAN Member Research Subcommittee. Neurology (2011) 2.59
Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis. Am J Respir Crit Care Med (2001) 2.55
Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin Pharmacol Ther (2007) 2.53
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells. J Exp Med (2000) 2.40
Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J Exp Med (1999) 2.39
DSPP mutation in dentinogenesis imperfecta Shields type II. Nat Genet (2001) 2.39
Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol (2001) 2.38
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Effects of telephone versus face-to-face interview modes on reports of alcohol consumption. Addiction (2000) 2.34
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet (1996) 2.32
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab (2010) 2.30
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene (2009) 2.26
Seven novel methylation guide small nucleolar RNAs are processed from a common polycistronic transcript by Rat1p and RNase III in yeast. Mol Cell Biol (1999) 2.20
TLR signaling by tumor and immune cells: a double-edged sword. Oncogene (2008) 2.18
The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Cell (2000) 2.18
Inactivation and repression by ammonium of the nitrate reducing system in chlorella. Biochem Biophys Res Commun (1970) 2.17
Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study. Heart (2009) 2.16
A 10-year national trend study of alcohol consumption, 1984-1995: is the period of declining drinking over? Am J Public Health (2000) 2.12
The clinical spectrum of unruptured intracranial aneurysms. Arch Neurol (1993) 2.11
Average volume of alcohol consumption, patterns of drinking, and all-cause mortality: results from the US National Alcohol Survey. Am J Epidemiol (2001) 2.11
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. J Pharmacol Exp Ther (1999) 2.10
Identification of Pandoraea species by 16S ribosomal DNA-based PCR assays. J Clin Microbiol (2001) 2.09
Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation. Circ Res (1995) 2.09
Feature (gene) selection in gene expression-based tumor classification. Mol Genet Metab (2001) 2.08
Emergence of H3N2 reassortant influenza A viruses in North American pigs. Vet Microbiol (2000) 2.06
Risk of second primary in situ and invasive melanoma in a Dutch population-based cohort: 1989-2008. Br J Dermatol (2012) 2.03
Elevated serum and synovial fluid TNF-like ligand 1A (TL1A) is associated with autoantibody production in patients with rheumatoid arthritis. Scand J Rheumatol (2013) 2.02
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res (2000) 2.00
Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch Intern Med (2000) 1.99
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A (1998) 1.98
The efficacy and six-week tolerability of simvastatin 80 and 160 mg/day. Am J Cardiol (1997) 1.98
A 3,000-year record of penguin populations. Nature (2000) 1.94
Who drinks most of the alcohol in the US? The policy implications. J Stud Alcohol (1999) 1.94
Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg (2006) 1.91
Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends. J Biol Chem (1996) 1.90
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. Cancer Res (1984) 1.88
Effects of pyrethroid insecticides on subjects engaged in packaging pyrethroids. Br J Ind Med (1988) 1.87
Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty. Circulation (1996) 1.86
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun (1997) 1.84
Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. Br J Cancer (2008) 1.83
Evidence that HetR protein is an unusual serine-type protease. Proc Natl Acad Sci U S A (1998) 1.83
Coronary heart disease in China. Heart (2008) 1.82
Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry (2000) 1.81
Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids. J Biol Chem (1997) 1.80
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene (2000) 1.76
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc Natl Acad Sci U S A (1998) 1.76
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene (2009) 1.76
Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Curr Biol (1999) 1.75
Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Blood (1998) 1.74
Subsite-specific incidence rate and stage of disease in colorectal cancer by race, gender, and age group in the United States, 1992-1997. Cancer (2001) 1.73
KLF8 transcription factor participates in oncogenic transformation. Oncogene (2006) 1.71
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). J Biol Chem (1999) 1.71
Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9. J Immunol (1991) 1.70
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. Neurology (2003) 1.70
High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clin Microbiol Infect (2010) 1.70
Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group. Arch Intern Med (2000) 1.69
Implementing the quantum von Neumann architecture with superconducting circuits. Science (2011) 1.68
The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J Biol Chem (1998) 1.67
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem (2000) 1.67
Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations. Br J Clin Pharmacol (1999) 1.66
KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9. Oncogene (2010) 1.65
Update on the incidence and mortality from melanoma in the United States. J Am Acad Dermatol (1999) 1.64
Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene (1997) 1.64