Published in Nature on September 13, 2012
The hallmarks of aging. Cell (2013) 14.29
FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97. Curr Biol (2014) 2.01
The biology of proteostasis in aging and disease. Annu Rev Biochem (2015) 1.96
Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature (2014) 1.86
The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan. Cell (2015) 1.86
Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction. Mol Cell (2015) 1.78
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Modulation of the maladaptive stress response to manage diseases of protein folding. PLoS Biol (2014) 1.54
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell (2015) 1.50
DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. PLoS Genet (2016) 1.47
Structural biology of the proteasome. Annu Rev Biophys (2013) 1.42
FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature (2015) 1.23
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun (2015) 1.21
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife (2015) 1.12
Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol (2013) 1.12
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci (2015) 1.09
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep (2013) 1.06
Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet (2014) 1.06
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature (2014) 1.06
Transcriptional and epigenetic regulation of autophagy in aging. Autophagy (2015) 0.97
Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging. Int J Cell Biol (2013) 0.97
Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J (2015) 0.96
Chaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasome. Biomolecules (2014) 0.95
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins. Proc Natl Acad Sci U S A (2015) 0.93
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans. FASEB J (2014) 0.93
Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging. Aging Cell (2013) 0.93
Enhancing protein disaggregation restores proteasome activity in aged cells. Aging (Albany NY) (2013) 0.92
Ubiquitin sets the timer: impacts on aging and longevity. Nat Struct Mol Biol (2014) 0.92
Systemic DNA damage responses: organismal adaptations to genome instability. Trends Genet (2014) 0.90
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res (2013) 0.89
Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress. FASEB J (2013) 0.88
Defining and measuring autophagosome flux—concept and reality. Autophagy (2014) 0.87
Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest (2015) 0.86
FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell (2013) 0.85
Molecular identification and characterization of Trichinella spiralis proteasome subunit beta type-7. Parasit Vectors (2015) 0.84
The ubiquitin proteasome system in Caenorhabditis elegans and its regulation. Redox Biol (2014) 0.84
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet (2014) 0.84
Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2016) 0.84
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. Elife (2015) 0.83
Base-CP proteasome can serve as a platform for stepwise lid formation. Biosci Rep (2015) 0.83
Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset. PLoS One (2014) 0.83
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc Natl Acad Sci U S A (2014) 0.83
Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. PLoS Genet (2015) 0.82
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans. Aging (Albany NY) (2013) 0.82
Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress. Front Cell Infect Microbiol (2013) 0.82
Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell (2016) 0.82
Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.82
Dopamine signaling promotes the xenobiotic stress response and protein homeostasis. EMBO J (2016) 0.82
The regulation of the autophagic network and its implications for human disease. Int J Biol Sci (2013) 0.82
n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease. PLoS One (2014) 0.82
Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes Cells (2014) 0.82
It's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegans. PLoS Genet (2014) 0.81
Hypoxia disrupts proteostasis in Caenorhabditis elegans. Aging Cell (2014) 0.81
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res (2016) 0.80
18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal (2016) 0.79
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Hum Mol Genet (2016) 0.79
A functional genomic screen for evolutionarily conserved genes required for lifespan and immunity in germline-deficient C. elegans. PLoS One (2014) 0.78
Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset. Curr Genomics (2014) 0.78
PCH-2 regulates Caenorhabditis elegans lifespan. Aging (Albany NY) (2015) 0.78
Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. PLoS Biol (2015) 0.78
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Cell Metab (2015) 0.78
Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy (2016) 0.78
Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway. PLoS Genet (2016) 0.78
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77
Methodological considerations for heat shock of the nematode Caenorhabditis elegans. Methods (2014) 0.77
The innate immune system as mediator of systemic DNA damage responses. Commun Integr Biol (2013) 0.77
Repair or Destruction: An Intimate Liaison Between Ubiquitin Ligases and Molecular Chaperones in Proteostasis. FEBS Lett (2017) 0.77
Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol (2016) 0.76
The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions. Front Neuroanat (2016) 0.76
Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage. J Gerontol A Biol Sci Med Sci (2014) 0.76
Profiling of ubiquitination pathway genes in peripheral cells from patients with frontotemporal dementia due to C9ORF72 and GRN mutations. Int J Mol Sci (2015) 0.76
Mediation of organismal aging and somatic proteostasis by the germline. Front Mol Biosci (2015) 0.76
Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans. Sci Rep (2016) 0.76
Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev (2015) 0.75
Proteasome function is not impaired in healthy aging of the lung. Aging (Albany NY) (2015) 0.75
New insights into old worm proteomes. Worm (2016) 0.75
The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina. F1000Res (2014) 0.75
Common cell biologic and biochemical changes in aging and age-related diseases of the eye: toward new therapeutic approaches to age-related ocular diseases. Invest Ophthalmol Vis Sci (2013) 0.75
Higher expression of somatic repair genes in long-lived ant queens than workers. Aging (Albany NY) (2016) 0.75
The disposable soma theory of aging in reverse. Cell Res (2013) 0.75
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7. PLoS Genet (2017) 0.75
Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system. Open Biol (2017) 0.75
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nat Commun (2016) 0.75
Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases. Front Mol Neurosci (2017) 0.75
Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY) (2016) 0.75
Ubiquitin and ubiquitin-like proteins in cardiac disease and protection. Curr Drug Targets (2015) 0.75
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers. Proc Natl Acad Sci U S A (2016) 0.75
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol (2016) 0.75
Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae. Aging Cell (2016) 0.75
Proteostasis, oxidative stress and aging. Redox Biol (2017) 0.75
Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans. PLoS One (2017) 0.75
Proteostasis of Huntingtin in Health and Disease. Int J Mol Sci (2017) 0.75
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Front Neurosci (2017) 0.75
Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity. Worm (2017) 0.75
TOR-mediated regulation of metabolism in aging. Aging Cell (2017) 0.75
Redox regulation of proteasome function. Redox Biol (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J (1991) 23.69
Unlocking the secrets of the genome. Nature (2009) 11.80
Impairment of the ubiquitin-proteasome system by protein aggregation. Science (2001) 11.51
Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) 8.43
The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 7.21
Evolution of ageing. Nature (1977) 6.49
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet (2001) 6.45
Signals from the reproductive system regulate the lifespan of C. elegans. Nature (1999) 6.41
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
Opposing activities protect against age-onset proteotoxicity. Science (2006) 5.85
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J (2000) 5.30
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem (1999) 4.77
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18
Timing requirements for insulin/IGF-1 signaling in C. elegans. Science (2002) 4.06
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev (2003) 3.92
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Sex and death: what is the connection? Cell (2005) 3.70
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell (2005) 3.28
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell (2001) 2.91
A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell (2001) 2.90
The glp-1 locus and cellular interactions in early C. elegans embryos. Cell (1987) 2.81
Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. BMC Mol Biol (2008) 2.73
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell (2006) 2.63
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol (2005) 2.49
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol (2011) 2.32
SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10
Calorie restriction and aging: a life-history analysis. Evolution (2000) 2.00
Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant. FASEB J (2005) 1.97
Proteasomal dysfunction in aging and Huntington disease. Neurobiol Dis (2010) 1.85
Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine. J Gerontol (1979) 1.69
Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. J Neurosci (2006) 1.65
The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Proc Natl Acad Sci U S A (2011) 1.57
Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc Natl Acad Sci U S A (2002) 1.48
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A (2007) 1.46
A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Ann N Y Acad Sci (2010) 1.42
A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nat Methods (2010) 1.20
Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem (2002) 0.97
Autophagy links lipid metabolism to longevity in C. elegans. Autophagy (2012) 0.89
Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders. J Proteomics (2010) 0.82
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Adapting proteostasis for disease intervention. Science (2008) 13.22
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature (2007) 6.61
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell (2011) 6.05
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Opposing activities protect against age-onset proteotoxicity. Science (2006) 5.85
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem (2008) 5.22
The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11
Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. Nat Methods (2004) 4.62
Bio3d: an R package for the comparative analysis of protein structures. Bioinformatics (2006) 4.44
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res (2011) 4.43
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol (2013) 3.88
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J (2009) 3.61
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science (2007) 3.46
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32
The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87
The fold of alpha-synuclein fibrils. Proc Natl Acad Sci U S A (2008) 2.82
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol (2009) 2.68
Large-area vapor-phase growth and characterization of MoS(2) atomic layers on a SiO(2) substrate. Small (2012) 2.66
The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A (2004) 2.50
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol (2011) 2.38
Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (2009) 2.33
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol (2003) 2.32
Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). Proc Natl Acad Sci U S A (2010) 2.30
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell (2013) 2.20
The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci (2008) 2.10
SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10
Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol (2011) 2.06
Similarities and differences between selective and nonselective BAFF blockade in murine SLE. J Clin Invest (2006) 2.05
Direct laser writing of micro-supercapacitors on hydrated graphite oxide films. Nat Nanotechnol (2011) 2.02
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature (2003) 1.98
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis (2011) 1.91
Ultra-stable nanoparticles of CdSe revealed from mass spectrometry. Nat Mater (2004) 1.86
Vapour phase growth and grain boundary structure of molybdenum disulphide atomic layers. Nat Mater (2013) 1.83
The challenge of protein structure determination--lessons from structural genomics. Protein Sci (2007) 1.82
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
Graphene quantum dots derived from carbon fibers. Nano Lett (2012) 1.79
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A (2006) 1.78
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol (2008) 1.77
Protein homeostasis and aging in neurodegeneration. J Cell Biol (2010) 1.76
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature (2012) 1.75
Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding. Proc Natl Acad Sci U S A (2009) 1.71
A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation. Mol Cell (2007) 1.70
Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G. J Virol (2006) 1.69
The dictyostelium kinome--analysis of the protein kinases from a simple model organism. PLoS Genet (2006) 1.69
Synthesis and characterization of chiral mesoporous silica. Nature (2004) 1.66
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell (2008) 1.65
Assessment of computational methods for predicting the effects of missense mutations in human cancers. BMC Genomics (2013) 1.64
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell (2009) 1.64
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins. PLoS One (2012) 1.54
Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53
The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol (2003) 1.52
Prohibitins and the functional compartmentalization of mitochondrial membranes. J Cell Sci (2009) 1.49
A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer (2010) 1.46
Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor. J Biol Chem (2007) 1.43
Complex zeolite structure solved by combining powder diffraction and electron microscopy. Nature (2006) 1.43
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun (2013) 1.42
Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta. Genome Biol (2013) 1.41
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell (2011) 1.39
The Capsaspora genome reveals a complex unicellular prehistory of animals. Nat Commun (2013) 1.39
Intrinsic structural defects in monolayer molybdenum disulfide. Nano Lett (2013) 1.38
Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Mol Biol Cell (2006) 1.38
From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle (2011) 1.36
The trifecta of aging in Caenorhabditis elegans. Exp Gerontol (2006) 1.35
Visualizing and identifying single atoms using electron energy-loss spectroscopy with low accelerating voltage. Nat Chem (2009) 1.34
Growth of bilayer graphene on insulating substrates. ACS Nano (2011) 1.33
Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol (2015) 1.33
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
Large-pore apertures in a series of metal-organic frameworks. Science (2012) 1.29
Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab (2009) 1.27
Gated tunability and hybridization of localized plasmons in nanostructured graphene. ACS Nano (2013) 1.27
A stable cathode for the aprotic Li-O2 battery. Nat Mater (2013) 1.26
Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction. ACS Nano (2011) 1.25
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One (2009) 1.25
Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature (2012) 1.25
Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases. Sci Signal (2012) 1.24
Graphene-antenna sandwich photodetector. Nano Lett (2012) 1.24
Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. J Biol Chem (2007) 1.24