Published in Nat Med on June 01, 2001
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85
Development, maintenance and disruption of the blood-brain barrier. Nat Med (2013) 2.62
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Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest (2004) 1.74
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Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest (2012) 1.57
Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice. Biol Reprod (2012) 1.52
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The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development (2009) 1.41
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The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26
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Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut (2012) 1.08
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Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol (2010) 1.07
Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice. J Clin Invest (2010) 1.06
Basal cell carcinoma: from the molecular understanding of the pathogenesis to targeted therapy of progressive disease. J Skin Cancer (2010) 1.06
Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. PLoS One (2010) 1.04
Brothers and sisters: molecular insights into arterial-venous heterogeneity. Circ Res (2008) 1.03
Arterial versus venous endothelial cells. Cell Tissue Res (2008) 1.01
Tumor-stromal interactions in pancreatic cancer. Crit Rev Oncog (2013) 1.01
Genetic contributions to the development of retinopathy of prematurity. Pediatr Res (2009) 1.01
MicroRNAs in skin and wound healing. Physiol Genomics (2010) 1.00
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res (2008) 0.99
Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol (2009) 0.99
Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem (2010) 0.99
Angiogenesis and chronic kidney disease. Fibrogenesis Tissue Repair (2010) 0.99
Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage. PLoS One (2013) 0.98
Angiogenic factors stimulate growth of adult neural stem cells. PLoS One (2010) 0.98
Therapeutic angiogenesis: controlled delivery of angiogenic factors. Ther Deliv (2012) 0.97
Fishing for novel angiogenic therapies. Br J Pharmacol (2003) 0.97
Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor. Am J Pathol (2003) 0.96
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res (2015) 0.96
Hedgehog signaling in prostate cancer and its therapeutic implication. Int J Mol Sci (2013) 0.96
Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis. Basic Res Cardiol (2009) 0.96
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An α-smooth muscle actin (acta2/αsma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One (2014) 0.95
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol (2010) 0.94
Controlled delivery of sonic hedgehog morphogen and its potential for cardiac repair. PLoS One (2013) 0.94
Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Neurochem Res (2011) 0.93
Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of Hedgehog pathway in a mouse model of colorectal cancer. Int J Mol Sci (2012) 0.93
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Possible novel targets for therapeutic angiogenesis. Curr Opin Pharmacol (2008) 0.91
New molecular pathways in angiogenesis. Br J Cancer (2003) 0.91
The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer. Int J Breast Cancer (2011) 0.91
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Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia. Mol Ther (2011) 0.88
Sonic hedgehog promotes angiogenesis and osteogenesis in a coculture system consisting of primary osteoblasts and outgrowth endothelial cells. Tissue Eng Part A (2010) 0.88
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood (2012) 0.88
The Hedgehog transcription factor Gli3 modulates angiogenesis. Circ Res (2009) 0.87
Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends Cardiovasc Med (2007) 0.87
Inhibition of patched-1 prevents injury-induced neointimal hyperplasia. Arterioscler Thromb Vasc Biol (2013) 0.87
Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels. Dev Dyn (2008) 0.87
Life is a pattern: vascular assembly within the embryo. Front Biosci (Elite Ed) (2012) 0.86
Control of blood vessel identity: from embryo to adult. Ann Vasc Dis (2008) 0.86
Sonic hedgehog: its expression in a healing cornea and its role in neovascularization. Mol Vis (2009) 0.86
Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesis. PLoS One (2012) 0.85
Endothelial primary cilia inhibit atherosclerosis. EMBO Rep (2016) 0.85
Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein. Lab Invest (2012) 0.83
Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma. United European Gastroenterol J (2013) 0.83
Angiogenic therapy for cardiac repair based on protein delivery systems. Heart Fail Rev (2012) 0.83
Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries. Sci Rep (2015) 0.83
Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling. J Biol Chem (2012) 0.83
Hedgehog signaling in hematopoiesis. Crit Rev Eukaryot Gene Expr (2010) 0.83
Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery (2012) 0.83
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