Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 151919)

Published in J Clin Invest on February 01, 2003

Authors

Nigel A Calcutt1, Karen L Allendoerfer, Andrew P Mizisin, Alicia Middlemas, Jason D Freshwater, Monica Burgers, Rigel Ranciato, Jean-Dominique Delcroix, Frederick R Taylor, Renee Shapiro, Kathy Strauch, Henryk Dudek, Thomas M Engber, Alphonse Galdes, Lee L Rubin, David R Tomlinson

Author Affiliations

1: Department of Pathology, University of California at San Diego, La Jolla, California 92093-0612, USA. ncalcutt@ucsd.edu

Articles citing this

Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics (2009) 1.75

Oxidative stress and diabetic neuropathy: a new understanding of an old problem. J Clin Invest (2003) 1.61

Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev (2010) 1.33

Diabetes and the enteric nervous system. Neurogastroenterol Motil (2007) 1.19

A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice. Eur J Pharmacol (2007) 1.14

Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy. Circulation (2009) 1.10

Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult. Acta Neuropathol (2010) 1.04

GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes Obes Metab (2011) 0.99

Neural influences on sonic hedgehog and apoptosis in the rat penis. Biol Reprod (2008) 0.94

Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes. Am J Physiol Endocrinol Metab (2009) 0.93

Adenylyl cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice. BMC Neurosci (2011) 0.88

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury. J Neurosci (2016) 0.84

Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein. Lab Invest (2012) 0.83

Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling. Antioxid Redox Signal (2015) 0.81

Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice. PLoS One (2010) 0.81

Emerging therapy for diabetic neuropathy: cell therapy targeting vessels and nerves. Endocr Metab Immune Disord Drug Targets (2012) 0.79

Voluntary movements as a possible non-reflexive pain assay. Mol Pain (2013) 0.78

Cell therapy for diabetic neuropathy using adult stem or progenitor cells. Diabetes Metab J (2013) 0.77

Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice. BMC Neurosci (2013) 0.77

Gene therapy for the treatment of diabetic neuropathy. Curr Diab Rep (2008) 0.75

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest (2017) 0.75

Nerves and hydrogen peroxide: how old enemies become new friends. Neural Regen Res (2017) 0.75

Articles cited by this

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med (2001) 3.85

Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (1997) 3.84

Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice. Anat Rec (1970) 3.03

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell (1992) 2.80

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell (1994) 2.58

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50

Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia (2001) 2.25

Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. J Cell Biol (1994) 1.67

Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy. J Neurosci Res (1990) 1.65

Hedgehog and patched in neural development and disease. Neuron (1998) 1.61

Enhanced potency of human Sonic hedgehog by hydrophobic modification. Biochemistry (2001) 1.49

Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev (2001) 1.31

Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J Cell Biol (2000) 1.22

Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes (1999) 1.16

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat Med (1995) 1.14

Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy. Brain Res Brain Res Rev (1995) 1.14

Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons. J Neurosci (2001) 1.13

A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. Am J Hum Genet (2000) 1.10

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J Pharm Sci (2002) 1.10

Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors. Diabetes (1997) 1.09

Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy. Acta Neuropathol (1998) 1.06

Human diabetic perineurial cell basement membrane thickening. Lab Invest (1981) 1.03

Experimental diabetic neuropathy: impairment of slow transport with changes in axon cross-sectional area. Proc Natl Acad Sci U S A (1985) 1.01

Reduced myelinated fiber size correlates with loss of axonal neurofilaments in peripheral nerve of chronically streptozotocin diabetic rats. Am J Pathol (1990) 0.99

Human recombinant nerve growth factor replaces deficient neurotrophic support in the diabetic rat. Eur J Neurosci (1995) 0.98

Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats. J Neuropathol Exp Neurol (1999) 0.95

Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. Diabetologia (2001) 0.93

Psoriatic keratinocytes express high levels of nerve growth factor. Acta Derm Venereol (1998) 0.92

Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy. Acta Neuropathol (1998) 0.92

Neurofilament and tubulin gene expression in progressive experimental diabetes: failure of synthesis and export by sensory neurons. Brain (1999) 0.92

Nerve growth factor treatment increases stimulus-evoked release of sensory neuropeptides in the rat spinal cord. Eur J Neurosci (1997) 0.88

Perineurium inflammation and altered connexin isoform expression in a rat model of diabetes related peripheral neuropathy. Neurosci Lett (2001) 0.88

TX14(A), a prosaposin-derived peptide, reverses established nerve disorders in streptozotocin-diabetic rats and prevents them in galactose-fed rats. J Neuropathol Exp Neurol (2001) 0.87

Perineurial abnormalities in the spontaneously diabetic dog. Acta Neuropathol (1999) 0.86

Reduced ciliary neuronotrophic factor-like activity in nerves from diabetic or galactose-fed rats. Brain Res (1992) 0.84

Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. Eur J Pharmacol (1995) 0.83

Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. J Neuropathol Exp Neurol (1987) 0.83

Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve. Eur J Pharmacol (1994) 0.82

Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia. Brain Res (2000) 0.82

BDNF attenuates functional and structural disorders in nerves of galactose-fed rats. J Neuropathol Exp Neurol (1997) 0.82

Articles by these authors

A paracrine requirement for hedgehog signalling in cancer. Nature (2008) 8.16

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell (2004) 5.95

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64

A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (2010) 3.60

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science (2014) 3.37

Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron (2003) 3.27

A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15

Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem (2003) 2.42

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A (2003) 2.25

GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett (2009) 2.17

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14

What is IgG4? A review of the biology of a unique immunoglobulin subtype. Curr Opin Rheumatol (2011) 1.85

miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A (2010) 1.83

Preventive pharmacologic treatments for episodic migraine in adults. J Gen Intern Med (2013) 1.70

Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol (2006) 1.69

MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers. Proc Natl Acad Sci U S A (2010) 1.64

The hedgehog pathway and neurological disorders. Annu Rev Neurosci (2006) 1.51

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes (2003) 1.50

Temporal gene expression during differentiation of human embryonic stem cells and embryoid bodies. Hum Reprod (2004) 1.49

Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48

Absolute risk reduction in total mortality with implantable cardioverter defibrillators: analysis of primary and secondary prevention trial data to aid risk/benefit analysis. Europace (2013) 1.44

Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain (2004) 1.40

ICD lead implantation following sharp cannulation of a blocked superior vena cava. Pacing Clin Electrophysiol (2010) 1.39

Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J Neurosci (2006) 1.34

Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett (2008) 1.31

Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem (2008) 1.29

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol (2005) 1.25

Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development (2004) 1.24

Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes. Diabetes (2009) 1.24

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21

Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase. Diabetes (2004) 1.20

Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19

The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS One (2012) 1.18

Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol (2004) 1.17

Assays for the identification and prioritization of drug candidates for spinal muscular atrophy. Assay Drug Dev Technol (2014) 1.13

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci (2003) 1.12

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J Pharm Sci (2002) 1.10

Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS One (2008) 1.09

Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Arch Ophthalmol (2006) 1.08

Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons. Mol Cell Neurosci (2005) 1.07

Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. J Mol Biol (2002) 1.06

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. PLoS One (2008) 1.05

Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst (2013) 1.04

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes. Brain Res (2006) 1.02

A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol (2011) 1.02

Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res (2011) 1.02

BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol (2003) 1.01

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. J Neurosci (2009) 1.01

Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. Diabetes (2007) 1.00

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin. Mol Cell Neurosci (2007) 1.00

A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol (2012) 1.00

Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry (2006) 0.99

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol (2012) 0.98

The blood-nerve barrier: structure and functional significance. Methods Mol Biol (2011) 0.98

Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury. Eur J Neurosci (2005) 0.98

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats. Psychoneuroendocrinology (2012) 0.97

Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol (2009) 0.97

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy. Diabetes (2006) 0.96

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins. Proc Natl Acad Sci U S A (2009) 0.96

Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation. Brain Behav Immun (2011) 0.96

Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh corgis and boxers. J Neurol Sci (2012) 0.95

Discovery and preclinical development of vismodegib. Expert Opin Drug Discov (2014) 0.95

Endoneurial microvascular pathology in feline diabetic neuropathy. Microvasc Res (2007) 0.94

Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. J Pain (2012) 0.93

Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons. Mol Cell Neurosci (2002) 0.93

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol (2012) 0.93

The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge. Int Immunol (2004) 0.93

Efficacy and tolerability of rizatriptan for the treatment of acute migraine in sumatriptan non-responders. Cephalalgia (2010) 0.93

Selection, Preparation, and Evaluation of Small- Molecule Inhibitors of Toll-Like Receptor 4. ACS Med Chem Lett (2010) 0.92

Neurological disease in wild loggerhead sea turtles Caretta caretta. Dis Aquat Organ (2006) 0.90

Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. J Neurol Sci (2007) 0.90

Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol (2011) 0.90

Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment. J Mol Biol (2003) 0.89

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4. J Pharm Biomed Anal (2011) 0.87

Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun (2012) 0.87

Stoichiometry of LTbetaR binding to LIGHT. Biochemistry (2006) 0.87

Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes (2003) 0.86

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A (2013) 0.86

Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol (2011) 0.85

Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. J Neuropathol Exp Neurol (2013) 0.85

Development of a chip-based capillary gel electrophoresis method for quantification of a half-antibody in immunoglobulin G4 samples. Electrophoresis (2004) 0.84

Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog. Neuromuscul Disord (2004) 0.84

Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain Behav Immun (2010) 0.83

Potent agonists of the Hedgehog signaling pathway. Bioorg Med Chem Lett (2009) 0.83

Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol (2012) 0.83

Purifying the hedgehog protein and its variants. Methods Mol Biol (2007) 0.83

Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetes. Diabetes (2009) 0.82

Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathy. Ann N Y Acad Sci (2002) 0.82

Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol (2006) 0.82