Published in J Leukoc Biol on June 01, 2001
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet (2009) 13.03
A diverse range of gene products are effectors of the type I interferon antiviral response. Nature (2011) 12.86
Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A (2008) 8.56
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet (2005) 4.80
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature (2013) 4.45
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J Virol (2002) 4.31
Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol (2010) 3.53
Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol (2007) 3.53
Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. J Virol (2006) 3.50
Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol (2014) 3.47
Interferon-stimulated genes and their antiviral effector functions. Curr Opin Virol (2011) 3.44
Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15. Proc Natl Acad Sci U S A (2006) 3.31
The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol (2012) 3.17
High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay. RNA (2008) 3.13
Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis (2007) 2.89
Awakening dormant haematopoietic stem cells. Nat Rev Immunol (2010) 2.88
Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection. J Virol (2002) 2.55
ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc Natl Acad Sci U S A (2008) 2.48
A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A (2010) 2.41
Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection. J Virol (2002) 2.38
Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol (2004) 2.35
Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J Virol (2007) 2.35
INTERFEROME: the database of interferon regulated genes. Nucleic Acids Res (2008) 2.31
Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity (2012) 2.23
Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J Virol (2008) 2.23
Interferon-stimulated gene 15 and the protein ISGylation system. J Interferon Cytokine Res (2010) 2.14
A genomic approach to human autoimmune diseases. Annu Rev Immunol (2010) 2.10
Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. J Virol (2005) 1.96
Regulation of hepatic innate immunity by hepatitis C virus. Nat Med (2013) 1.93
Innate cellular response to virus particle entry requires IRF3 but not virus replication. J Virol (2004) 1.91
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol (2006) 1.82
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol (2006) 1.80
Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci U S A (2010) 1.77
Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum (2007) 1.72
Immunologic strategies for HIV-1 remission and eradication. Science (2014) 1.70
Stem cell quiescence. Clin Cancer Res (2011) 1.69
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog (2010) 1.66
Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. J Virol (2002) 1.66
Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol (2006) 1.64
One-year evaluation of factors affecting the biological activity of interferon beta in multiple sclerosis patients. J Neurol (2010) 1.60
Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. J Virol (2005) 1.59
The interferon stimulated gene 54 promotes apoptosis. J Biol Chem (2010) 1.58
Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol (2007) 1.58
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. Proc Natl Acad Sci U S A (2005) 1.56
Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol (2003) 1.56
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity. J Exp Med (2008) 1.55
Interferons limit inflammatory responses by induction of tristetraprolin. Blood (2006) 1.53
Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe (2014) 1.53
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PLoS Negl Trop Dis (2011) 1.50
The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev (2007) 1.48
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. J Interferon Cytokine Res (2009) 1.42
Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels. J Virol (2007) 1.41
A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus. J Hepatol (2011) 1.41
A novel unsupervised method to identify genes important in the anti-viral response: application to interferon/ribavirin in hepatitis C patients. PLoS One (2007) 1.39
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39
Phospholipid scramblase 1 potentiates the antiviral activity of interferon. J Virol (2004) 1.39
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38
Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cells. J Virol (2007) 1.37
Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem (2009) 1.36
Genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells. J Virol (2005) 1.32
Engineered RNA viral synthesis of microRNAs. Proc Natl Acad Sci U S A (2010) 1.31
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. J Virol (2006) 1.30
Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. J Gen Virol (2009) 1.30
Innate immunity evasion by Dengue virus. Viruses (2012) 1.29
HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog (2013) 1.29
Viral defense, carcinogenesis and ISG15: novel roles for an old ISG. Cytokine Growth Factor Rev (2007) 1.29
Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLoS Pathog (2011) 1.28
Post-transcriptional control of the interferon system. Biochimie (2007) 1.28
Inhibitory effect of gamma interferon on BK virus gene expression and replication. J Virol (2006) 1.26
Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons. J Virol (2009) 1.24
IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. Proc Natl Acad Sci U S A (2011) 1.23
Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun (2008) 1.23
Recent advances in understanding viral evasion of type I interferon. Immunology (2013) 1.22
Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response. J Virol (2006) 1.21
Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. PLoS Pathog (2013) 1.20
Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. J Clin Immunol (2008) 1.20
Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J Virol (2007) 1.18
Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol (2010) 1.18
Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state. J Virol (2008) 1.18
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One (2011) 1.17
The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses. J Virol (2007) 1.16
Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 1.16
Viperin restricts chikungunya virus replication and pathology. J Clin Invest (2012) 1.16
Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis. J Transl Med (2011) 1.15
Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J Virol (2012) 1.15
HIV-1 and interferons: who's interfering with whom? Nat Rev Microbiol (2015) 1.14
Telomere length regulates ISG15 expression in human cells. Aging (Albany NY) (2009) 1.13
Interferon induced IFIT family genes in host antiviral defense. Int J Biol Sci (2013) 1.13
Interferon-γ and systemic autoimmunity. Discov Med (2013) 1.13
Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem (2011) 1.12
Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes. Blood (2008) 1.12
Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first 10 weeks of treatment. J Transl Med (2008) 1.11
Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev (2009) 1.10
Counteraction of the multifunctional restriction factor tetherin. Front Microbiol (2014) 1.09
System-based proteomic analysis of the interferon response in human liver cells. Genome Biol (2004) 1.09
Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB. J Virol (2009) 1.08
Forced IFIT-2 expression represses LPS induced TNF-alpha expression at posttranscriptional levels. BMC Immunol (2008) 1.07
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Collaborative management to achieve treatment guidelines. Impact on depression in primary care. JAMA (1995) 11.90
Sulphydryl groups in proteins. Biochem J (1937) 7.82
A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psychiatry (1996) 7.80
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell (1990) 7.12
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Tat trans-activates the human immunodeficiency virus through a nascent RNA target. Cell (1989) 6.28
Stepped collaborative care for primary care patients with persistent symptoms of depression: a randomized trial. Arch Gen Psychiatry (1999) 4.57
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc Natl Acad Sci U S A (1994) 4.53
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J (1997) 4.53
Rate of Liberation of Acid by betabeta'-Dichlorodiethyl Sulphide and its Analogues in its Relation to the "Acid" Theory of Skin Vesication. Biochem J (1923) 4.50
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res (2001) 4.47
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell (1993) 4.10
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis (2003) 3.73
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2. EMBO J (1992) 3.65
Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell (1978) 3.53
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. Proc Natl Acad Sci U S A (2000) 3.51
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. Virology (1999) 3.44
Depressive symptoms and the cost of health services in HMO patients aged 65 years and older. A 4-year prospective study. JAMA (1997) 3.36
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
The role of the primary care physician in patients' adherence to antidepressant therapy. Med Care (1995) 3.29
Treatment costs, cost offset, and cost-effectiveness of collaborative management of depression. Psychosom Med (1998) 2.97
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol (2000) 2.71
Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J (1998) 2.68
Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene. EMBO J (1988) 2.66
Collagen fibril formation. Optimal in vitro conditions and preliminary kinetic results. J Biol Chem (1978) 2.65
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system. Mol Cell Biol (1991) 2.55
Carbon monoxide poisoning. BMJ (1999) 2.47
Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cells. Nucleic Acids Res (1981) 2.42
Arc-scanning very high-frequency digital ultrasound for 3D pachymetric mapping of the corneal epithelium and stroma in laser in situ keratomileusis. J Refract Surg (2000) 2.40
Femoral nerve block for pain relief in hip fracture: a dose finding study. Anaesthesia (2014) 2.36
A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J (1993) 2.28
2-5A-dependent RNase molecules dimerize during activation by 2-5A. J Biol Chem (1995) 2.27
Antigen-specific. I region-restricted interactions in vitro between tumor cell lines and T cell hybridomas. J Immunol (1982) 2.26
The association between chronic pelvic pain, psychiatric diagnoses, and childhood sexual abuse. Obstet Gynecol (1988) 2.20
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A (1992) 2.20
Outcomes of "inadequate" antidepressant treatment. J Gen Intern Med (1995) 2.19
The bromine reaction of pregnancy urine. Biochem J (1932) 2.14
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J (1999) 2.07
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res (1998) 2.04
Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells. Nature (1980) 2.03
Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature (1979) 2.01
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J (2000) 1.98
Medical symptoms without identified pathology: relationship to psychiatric disorders, childhood and adult trauma, and personality traits. Ann Intern Med (2001) 1.94
Spatiotemporal patterns of host-seeking Ixodes scapularis nymphs (Acari: Ixodidae) in the United States. J Med Entomol (2006) 1.90
Sampling outdoor, resting Anopheles gambiae and other mosquitoes (Diptera: Culicidae) in western Kenya with clay pots. J Med Entomol (2007) 1.89
Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines. Cancer Res (1989) 1.84
A randomized trial of relapse prevention of depression in primary care. Arch Gen Psychiatry (2001) 1.83
Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways. Mol Cell Biol (2000) 1.83
Systemic embolism in mitral valve disease. Br Heart J (1970) 1.81
rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells. J Virol (1983) 1.81
Sterol metabolism of micro-organisms: Yeast. Biochem J (1940) 1.78
Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA. J Biol Chem (1997) 1.77
Collagen fibril formation. Evidence for a multistep process. J Biol Chem (1979) 1.77
Evaluation of the carcinogenicity of chemicals: a review of the Monograph Program of the International Agency for Research on Cancer (1971 to 1977). Cancer Res (1978) 1.73
Are there detectable differences in quality of care or outcome of depression across primary care providers? Med Care (2000) 1.72
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science (1994) 1.72
Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection. J Infect Dis (1986) 1.72
The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. Proc Natl Acad Sci U S A (1995) 1.70
Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA. Nucleic Acids Res (1989) 1.70
DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. J Biol Chem (1999) 1.70
A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. EMBO J (2000) 1.68
Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. J Biol Chem (1994) 1.67
Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR. Mol Cell Biol (1998) 1.64
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology (1994) 1.63
Control of the ppp(a2'p)nA system in HeLa cells. Effects of interferon and virus infection. Eur J Biochem (1982) 1.61
Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells. J Exp Med (1981) 1.60
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. RNA (2001) 1.60
The education of depressed primary care patients: what do patients think of interactive booklets and a video? J Fam Pract (1997) 1.59
Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure. EMBO J (1985) 1.59
Malaria in Scotland and its presentation in a Glasgow hospital. Health Bull (Edinb) (1981) 1.56
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR. Virology (1995) 1.56
Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis. J Bone Miner Res (1993) 1.55
Synthesis and breakdown of pppA2'p5'A2'p5'A and transient inhibiton of protein synthesis in extracts from interferon-treated and control cells. Eur J Biochem (1978) 1.54
Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1990) 1.52
Intelligence in schizophrenia: meta-analysis of the research. Schizophr Bull (1984) 1.51
Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR. J Biol Chem (1995) 1.50
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest (1997) 1.48
Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. J Clin Invest (1995) 1.47
Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression. J Interferon Res (1989) 1.45
Should fewer premature infants be screened for retinopathy of prematurity in the managed care era? Pediatrics (1998) 1.45
Population-based care of depression: effective disease management strategies to decrease prevalence. Gen Hosp Psychiatry (1997) 1.44
A bipartite model of 2-5A-dependent RNase L. J Biol Chem (1997) 1.42