Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 3213224)

Published in J Transl Med on October 12, 2011

Authors

Tara L Spivey1, Lorenzo Uccellini, Maria Libera Ascierto, Gabriele Zoppoli, Valeria De Giorgi, Lucia Gemma Delogu, Alyson M Engle, Jaime M Thomas, Ena Wang, Francesco M Marincola, Davide Bedognetti

Author Affiliations

1: Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, Maryland 20892, USA.

Articles citing this

NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells. Cancer Res (2012) 1.46

Novel technologies and emerging biomarkers for personalized cancer immunotherapy. J Immunother Cancer (2016) 1.22

CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2. Br J Cancer (2013) 1.06

Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. J Transl Med (2013) 1.03

miRNA profiling discriminates types of rejection and injury in human renal allografts. Transplantation (2013) 0.96

IRF5 gene polymorphisms in melanoma. J Transl Med (2012) 0.86

A genetic inference on cancer immune responsiveness. Oncoimmunology (2012) 0.86

Interferon-γ and Tumor Necrosis Factor-α Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype. Sci Rep (2016) 0.85

Meta-analysis and metagenes: CXCL-13-driven signature as a robust marker of intratumoral immune response and predictor of breast cancer chemotherapeutic outcome. Oncoimmunology (2014) 0.85

A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon. PLoS One (2012) 0.82

Impact of carbon nanotubes and graphene on immune cells. J Transl Med (2014) 0.81

Issues in solid-organ transplantation in children: translational research from bench to bedside. Clinics (Sao Paulo) (2014) 0.81

Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway. Cell Mol Immunol (2012) 0.80

Checkpoint Inhibitors and Their Application in Breast Cancer. Breast Care (Basel) (2016) 0.80

A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer. Br J Cancer (2015) 0.79

Direct T cell-tumour interaction triggers TH1 phenotype activation through the modification of the mesenchymal stromal cells transcriptional programme. Br J Cancer (2014) 0.78

A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease. Haematologica (2012) 0.77

Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis. Oncoimmunology (2017) 0.77

Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation. PLoS One (2014) 0.76

Reflections upon human cancer immune responsiveness to T cell-based therapy. Cancer Immunol Immunother (2012) 0.76

Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue. Xenotransplantation (2013) 0.76

Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness. Cancer Immunol Res (2016) 0.76

Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators. J Clin Cell Immunol (2012) 0.75

Transplant biopsy beyond light microscopy. BMC Nephrol (2015) 0.75

Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight (2017) 0.75

Articles cited by this

(truncated to the top 100)

Pathogen recognition and innate immunity. Cell (2006) 44.14

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90

Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

The danger model: a renewed sense of self. Science (2002) 13.85

Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol (2005) 11.57

The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol (2004) 10.85

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98

International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev (2000) 7.17

CD4 T cells: fates, functions, and faults. Blood (2008) 7.03

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest (1998) 6.51

Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol (2001) 6.19

Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nat Biotechnol (2006) 5.92

Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med (2005) 5.02

Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol (2007) 4.75

Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant (2003) 4.54

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell (1993) 4.46

Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med (2003) 4.35

Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med (2010) 4.31

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem (2002) 4.03

Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology (2007) 3.87

Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med (2000) 3.84

Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41

Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med (2002) 3.39

Chemokines: multiple levels of leukocyte migration control. Trends Immunol (2004) 3.32

Lymphoid organ development: from ontogeny to neogenesis. Nat Immunol (2006) 3.15

Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comput Biol (2008) 3.02

Tracking STAT nuclear traffic. Nat Rev Immunol (2006) 2.99

CC chemokine receptor 5 and renal-transplant survival. Lancet (2001) 2.82

Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res (2007) 2.66

B-cell-depleting induction therapy and acute cellular rejection. N Engl J Med (2009) 2.56

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant (2004) 2.35

Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype. Kidney Int (2010) 2.28

Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am J Transplant (2009) 2.27

Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci U S A (2007) 2.27

Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant (2007) 2.25

Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol (2005) 2.24

Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer Res (2002) 2.21

Donor-derived IP-10 initiates development of acute allograft rejection. J Exp Med (2001) 2.17

Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature (1998) 2.17

Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol (2006) 2.06

Activities of IRF-1. J Interferon Cytokine Res (2002) 2.04

Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology (2006) 2.03

A signature of immune function genes associated with recurrence-free survival in breast cancer patients. Breast Cancer Res Treat (2011) 1.99

Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci U S A (2006) 1.96

FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am J Transplant (2008) 1.94

Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy. J Immunother (2010) 1.89

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity (1997) 1.89

Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharmacol (1998) 1.83

Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells. Eur J Immunol (2001) 1.80

A randomized, doubleblind, placebo-controlled, study of single-dose rituximab as induction in renal transplantation. Transplantation (2009) 1.79

Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation (2006) 1.75

The dual role of IL-10. Trends Immunol (2003) 1.72

Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). J Am Soc Nephrol (2005) 1.72

Proinflammatory effects of IL-10 during human endotoxemia. J Immunol (2000) 1.69

The immunologic constant of rejection. Trends Immunol (2008) 1.62

NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant (2010) 1.62

A molecular classifier for predicting future graft loss in late kidney transplant biopsies. J Clin Invest (2010) 1.61

Interstitial mononuclear cell populations in renal graft rejection. Identification by monoclonal antibodies in tissue sections. J Exp Med (1982) 1.59

Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol (2006) 1.57

Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J Immunol (1998) 1.56

Common cancer biomarkers. Cancer Res (2006) 1.56

The molecular phenotype of heart transplant biopsies: relationship to histopathological and clinical variables. Am J Transplant (2010) 1.54

An immunologic portrait of cancer. J Transl Med (2011) 1.50

Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int (2004) 1.48

The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course. Am J Transplant (2010) 1.43

Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. Circulation (2001) 1.42

Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection. Genome Biol (2007) 1.38

Incidence of C4d stain in protocol biopsies from renal allografts: results from a multicenter trial. Am J Transplant (2005) 1.37

Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. Am J Transplant (2008) 1.36

The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood (2000) 1.35

Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy. BMC Genomics (2009) 1.34

B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol (2006) 1.34

Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J Immunol (2002) 1.32

The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats. Am J Transplant (2008) 1.31

Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol (2003) 1.29

The complement system in B cell regulation. Mol Immunol (2004) 1.28

Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol (2010) 1.27

Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. J Immunol (2009) 1.27

CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest (2007) 1.22

Beneficial effects of targeting CCR5 in allograft recipients. Transplantation (2001) 1.22

Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts. Am J Transplant (2009) 1.21

Multiple pathways to allograft rejection. Transplantation (2002) 1.21

IPEX and FOXP3: clinical and research perspectives. J Autoimmun (2005) 1.21

Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Blood (2009) 1.20

Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages. J Biol Chem (2005) 1.20

Diagnosing rejection in renal transplants: a comparison of molecular- and histopathology-based approaches. Am J Transplant (2009) 1.19

Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice. J Autoimmun (2007) 1.19

Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. Am J Transplant (2004) 1.19

Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant (2005) 1.18

Clinical impact of tumor-infiltrating lymphocytes for survival in stage II colon cancer. Cancer (2010) 1.18

Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis. Am J Transplant (2009) 1.18

The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol (2003) 1.17

Characterization of intra-graft B cells during renal allograft rejection. Kidney Int (2008) 1.17

Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol (2009) 1.16

NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines. Int J Colorectal Dis (2007) 1.16

Gene-expression profiling in vaccine therapy and immunotherapy for cancer. Expert Rev Vaccines (2010) 1.15

Trafficking of natural killer cells. Curr Mol Med (2004) 1.14

Articles by these authors

A human memory T cell subset with stem cell-like properties. Nat Med (2011) 7.47

gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med (2011) 5.15

Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science (2013) 5.09

A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma. J Immunother (2002) 4.31

Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J Clin Oncol (2002) 4.15

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol (2005) 3.23

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 3.21

Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol (2009) 3.02

Tumour immunity: effector response to tumour and role of the microenvironment. Lancet (2008) 2.94

Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88

The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity (2013) 2.86

The immune score as a new possible approach for the classification of cancer. J Transl Med (2012) 2.79

Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus. Cancer Res (2007) 2.69

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 2.57

MicroRNA expression differentiates histology and predicts survival of lung cancer. Clin Cancer Res (2010) 2.48

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol (2005) 2.24

Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer Res (2002) 2.21

Extensive HLA class I allele promiscuity among viral CTL epitopes. Eur J Immunol (2007) 2.10

Lost in Translation: Obstacles to Translational Medicine. J Transl Med (2004) 2.03

The role of BRAF V600 mutation in melanoma. J Transl Med (2012) 2.00

A signature of immune function genes associated with recurrence-free survival in breast cancer patients. Breast Cancer Res Treat (2011) 1.99

Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Hum Gene Ther (2002) 1.96

Gene expression profiling of cutaneous wound healing. J Transl Med (2007) 1.91

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest (2011) 1.90

Quantitative real-time PCR: a powerful ally in cancer research. Trends Mol Med (2003) 1.88

MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells. J Transl Med (2009) 1.85

What's next in translational medicine? Clin Sci (Lond) (2007) 1.85

In support of descriptive studies; relevance to translational research. J Transl Med (2007) 1.82

Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res (2009) 1.81

A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers". J Transl Med (2008) 1.77

Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration. Genome Biol (2002) 1.74

Immunotherapy for melanoma: current status and perspectives. J Immunother (2010) 1.72

The dual role of IL-10. Trends Immunol (2003) 1.72

Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72

Clonal persistence and evolution during a decade of recurrent melanoma. J Invest Dermatol (2006) 1.69

Main roads to melanoma. J Transl Med (2009) 1.67

Tumors as elusive targets of T-cell-based active immunotherapy. Trends Immunol (2003) 1.67

The immunologic constant of rejection. Trends Immunol (2008) 1.62

Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res (2012) 1.61

Investigation of residual hepatitis C virus in presumed recovered subjects. Hepatology (2012) 1.61

Obstacles and opportunities in translational research. Nat Med (2005) 1.59

Cytokines and Immune Response in the Tumor Microenvironment. J Immunother (1991) (2001) 1.59

Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med (2008) 1.57

Immuno-oncology biomarkers 2010 and beyond: perspectives from the iSBTc/SITC biomarker task force. J Transl Med (2010) 1.57

Common cancer biomarkers. Cancer Res (2006) 1.56

Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going? J Natl Cancer Inst (2002) 1.56

What have we learned from cancer immunotherapy in the last 3 years? J Transl Med (2014) 1.52

Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells. Nat Immunol (2011) 1.51

An immunologic portrait of cancer. J Transl Med (2011) 1.50

Proteomic evaluation of archival cytologic material using SELDI affinity mass spectrometry: potential for diagnostic applications. Am J Clin Pathol (2002) 1.48

Research translation: a new frontier for clinical laboratories. Clin Chem Lab Med (2006) 1.48

Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures. Blood (2009) 1.46

Selection and validation of endogenous reference genes using a high throughput approach. BMC Genomics (2004) 1.45

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity. Cell Cycle (2008) 1.45

Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. Clin Cancer Res (2005) 1.39

Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection. Genome Biol (2007) 1.38

Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res (2009) 1.38

Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Cancer Res (2008) 1.38

Immunobiological characterization of cancer stem cells isolated from glioblastoma patients. Clin Cancer Res (2010) 1.37

Natural T cell immunity against cancer. Clin Cancer Res (2003) 1.36

Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy. BMC Genomics (2009) 1.34

Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis. J Transl Med (2008) 1.33

Ovarian cancer, the coagulation pathway, and inflammation. J Transl Med (2005) 1.33

The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment. J Transl Med (2013) 1.31