Published in PLoS One on September 08, 2011
Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol (2012) 2.21
IFN-inducible GTPases in host cell defense. Cell Host Microbe (2012) 1.53
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog (2012) 1.41
Immune response and immunopathology during toxoplasmosis. Semin Immunopathol (2012) 1.38
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18. PLoS Pathog (2012) 1.34
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog (2013) 1.34
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. PLoS Pathog (2013) 1.33
Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. Proc Natl Acad Sci U S A (2015) 1.07
The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. J Biol Chem (2012) 0.98
Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun (2013) 0.98
Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages. Infect Immun (2015) 0.98
Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. BMC Genomics (2015) 0.95
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance. PLoS One (2014) 0.93
Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One (2013) 0.90
Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun (2013) 0.89
Toxoplasma gondii development of its replicative niche: in its host cell and beyond. Eukaryot Cell (2014) 0.89
Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics (2013) 0.88
Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. J Mol Biol (2016) 0.88
Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Cell Microbiol (2016) 0.88
Interferon-γ restricts Toxoplasma gondii development in murine skeletal muscle cells via nitric oxide production and immunity-related GTPases. PLoS One (2012) 0.87
Interferon-induced guanylate-binding proteins in inflammasome activation and host defense. Nat Immunol (2016) 0.84
Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections. Microbiol Mol Biol Rev (2015) 0.82
Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity. J Virol (2016) 0.80
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity. PLoS Genet (2016) 0.79
Use and abuse of dendritic cells by Toxoplasma gondii. Virulence (2012) 0.79
Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses. Infect Immun (2014) 0.79
Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). Med Microbiol Immunol (2012) 0.79
Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis? Parasite Immunol (2015) 0.78
K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells. PLoS Pathog (2016) 0.78
Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. MBio (2015) 0.77
Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. PLoS Genet (2015) 0.77
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci U S A (2015) 0.76
Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells. Microbiol Spectr (2016) 0.76
Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system. Parasit Vectors (2017) 0.75
Different genotypes of Trypanosoma cruzi produce distinctive placental environment genetic response in chronic experimental infection. PLoS Negl Trop Dis (2017) 0.75
Toxoplasma Effectors Targeting Host Signaling and Transcription. Clin Microbiol Rev (2017) 0.75
TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles. Sci Rep (2017) 0.75
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem (1974) 113.22
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 16.65
Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science (1988) 7.96
Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol (2001) 6.19
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol (1994) 5.50
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature (2006) 4.50
Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (2006) 4.23
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol (2005) 4.21
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J Exp Med (2001) 3.75
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med (2006) 3.52
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS Pathog (2005) 3.25
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med (2011) 2.87
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol (2010) 2.83
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole. EMBO J (2001) 2.62
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe (2010) 2.57
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog (2009) 2.19
Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis. Mol Biochem Parasitol (1998) 2.13
IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunol (2004) 2.11
Transcriptional activation of the mouse Mx gene by type I interferon. Mol Cell Biol (1986) 2.04
Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus. Virology (1999) 2.02
Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. EMBO J (2008) 2.00
Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol (2007) 1.95
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cell Microbiol (2010) 1.94
p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect Immun (2005) 1.93
Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol (2009) 1.81
TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii. J Immunol (2006) 1.80
IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. Cell Microbiol (2007) 1.75
Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine. Infect Immun (2007) 1.55
The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. EMBO J (2001) 1.53
Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism. EMBO J (2000) 1.43
Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. J Mol Biol (2004) 1.35
The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. EMBO J (2003) 1.32
Transmembrane insertion of the Toxoplasma gondii GRA5 protein occurs after soluble secretion into the host cell. Mol Biol Cell (1999) 1.30
Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. Arch Virol (2005) 1.22
UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog (2010) 1.22
Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma. PLoS One (2009) 1.20
Toxoplasma gondii and the Immunity-Related GTPase (IRG) resistance system in mice: a review. Mem Inst Oswaldo Cruz (2009) 1.15
The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem (2001) 1.09
Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. Proc Natl Acad Sci U S A (2005) 1.06
Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics (2008) 1.06
Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. PLoS One (2010) 1.01
Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions? J Interferon Cytokine Res (2000) 1.00
Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii. Clin Exp Immunol (2009) 0.96
The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase. Mol Biol Cell (2010) 0.93
Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. Mol Biol Cell (2000) 0.90
A novel GTP-binding protein hGBP3 interacts with NIK/HGK. FEBS Lett (2002) 0.78
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15
Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature (2002) 3.93
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43
Sortagging: a versatile method for protein labeling. Nat Chem Biol (2007) 3.39
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 3.01
A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol (2006) 2.94
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci (2012) 2.90
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med (2011) 2.87
The known unknowns of antigen processing and presentation. Nat Rev Immunol (2008) 2.85
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem (2004) 2.75
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure (2006) 2.56
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity (2011) 2.50
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol Cell (2005) 2.43
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis (2008) 2.40
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2008) 2.38
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol (2011) 2.23
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem (2003) 2.22
A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J (2003) 2.18
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A (2011) 2.13
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc (2007) 2.10
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol (2006) 2.05
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03
Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A (2006) 1.95
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol (2007) 1.90
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol (2005) 1.85
Ubiquitin-like proteins. Annu Rev Biochem (2012) 1.84
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol (2006) 1.78
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods (2005) 1.78
Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J Biol Chem (2001) 1.78
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J (2008) 1.77
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell (2007) 1.75
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (2010) 1.74
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem (2004) 1.74
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature (2006) 1.73
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J (2009) 1.72
Identification of proteins associated with murine cytomegalovirus virions. J Virol (2004) 1.72
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem (2005) 1.71
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host Microbe (2009) 1.69
Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68
Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection. PLoS Pathog (2009) 1.66
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med (2002) 1.64
Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. J Am Chem Soc (2009) 1.63
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol (2006) 1.62
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe (2011) 1.62
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59
Making and breaking peptide bonds: protein engineering using sortase. Angew Chem Int Ed Engl (2011) 1.58
Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe (2013) 1.57
Screen for ISG15-crossreactive deubiquitinases. PLoS One (2007) 1.57
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J (2007) 1.56
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55
Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol (2011) 1.53
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J (2004) 1.53
Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. Eur J Immunol (2011) 1.52
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J Virol (2006) 1.52
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc Natl Acad Sci U S A (2008) 1.51
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol (2005) 1.50
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol (2002) 1.50
Identification of host cell factors required for intoxication through use of modified cholera toxin. J Cell Biol (2011) 1.47
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem (2003) 1.46
Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cell Microbiol (2012) 1.45
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell (2004) 1.44
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A (2008) 1.43
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunol Rev (2005) 1.43
Site-specific protein labeling via sortase-mediated transpeptidation. Curr Protoc Protein Sci (2009) 1.43
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol (2004) 1.42
Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol (2010) 1.42
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog (2012) 1.41
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci (2003) 1.40
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer Res (2005) 1.39