Published in Biochem Biophys Res Commun on July 13, 2001
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci U S A (2005) 3.83
Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis (2013) 3.07
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A (2002) 1.82
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene (2009) 1.34
Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics (2008) 1.28
Dysregulated lipid metabolism in cancer. World J Biol Chem (2012) 1.27
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4. J Biol Chem (2008) 1.23
Lipid metabolism emerges as a promising target for malignant glioma therapy. CNS Oncol (2013) 1.01
Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun (2009) 1.00
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells. Nutr Cancer (2009) 0.97
Fatty acid synthase: a novel target for antiglioma therapy. Br J Cancer (2006) 0.94
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol (2014) 0.91
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity. J Lipid Res (2010) 0.90
The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production. Infect Immun (2010) 0.88
Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.86
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers. Comput Struct Biotechnol J (2016) 0.85
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells. J Ocul Biol Dis Infor (2011) 0.82
The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res (2014) 0.82
Mitochondrial and nuclear genes of mitochondrial components in cancer. Curr Genomics (2009) 0.82
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth. Oncogene (2012) 0.82
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. J Gastroenterol (2012) 0.81
Imaging metabolic heterogeneity in cancer. Mol Cancer (2016) 0.80
Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma. Int J Clin Exp Pathol (2014) 0.80
Studies of Secondary Melanoma on C57BL/6J Mouse Liver Using 1H NMR Metabolomics. Metabolites (2013) 0.80
Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer. PLoS One (2015) 0.80
Parameter trajectory analysis to identify treatment effects of pharmacological interventions. PLoS Comput Biol (2013) 0.80
The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes. Mar Drugs (2015) 0.78
Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered. J Cell Physiol (2016) 0.77
Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase. BMC Complement Altern Med (2013) 0.77
The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors. Curr Pharm Biotechnol (2013) 0.77
Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells. PLoS One (2016) 0.77
Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway. J Cancer Res Clin Oncol (2015) 0.76
Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One (2013) 0.76
Inhibition of fatty acid synthase is protective in pulmonary hypertension. Br J Pharmacol (2016) 0.75
Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs. PLoS One (2017) 0.75
Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells. Oncogenesis (2017) 0.75
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science (2000) 4.62
Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem (1988) 3.83
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res (2000) 2.21
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res (1996) 2.18
Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol (1997) 1.93
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res (1997) 1.70
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res (1996) 1.69
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes. Proc Natl Acad Sci U S A (1997) 1.55
Comparison of immunoperoxidase and DNA in situ hybridization techniques in the diagnosis of cytomegalovirus colitis. Am J Clin Pathol (1988) 1.46
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res (1996) 1.34
Computed tomography of extracranial nerve sheath tumors with pathological correlation. J Comput Assist Tomogr (1983) 1.29
Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. Cancer (1998) 1.18
Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci. Mol Biol Cell (1996) 1.13
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. Cancer Lett (2001) 1.10
Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk. J Biol Chem (1992) 1.09
Esthesioneuroblastoma. Intermediate filaments, neuroendocrine, and tissue-specific antigens. Am J Clin Pathol (1987) 1.05
Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator. Am J Clin Pathol (1992) 1.04
Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis. J Antimicrob Chemother (1999) 1.01
The distribution of carcinoembryonic antigen in breast carcinoma. Diagnostic and prognostic implications. Cancer (1983) 0.99
Solitary bronchioloalveolar carcinoma: CT criteria. Radiology (1988) 0.98
Warthin's tumor-associated neoplasms: report of two cases and review of the literature. Ear Nose Throat J (1993) 0.98
Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer. Prostate (1998) 0.97
Increased fatty acid synthase is a therapeutic target in mesothelioma. Clin Cancer Res (2001) 0.97
Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models. Cancer Res (1996) 0.96
Canine laryngeal rhabdomyoma. Vet Pathol (1985) 0.95
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells. Oncogene (2009) 0.93
Hyperostotic esthesioneuroblastoma: CT and MR findings. J Comput Assist Tomogr (1988) 0.92
Expression of haptoglobin-related protein in primary and metastatic breast cancers. A longitudinal study of 48 fatal tumors. Am J Clin Pathol (1991) 0.92
Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaryocytic leukemia. Am J Clin Pathol (1987) 0.88
Immunoperoxidase stains of ganglion cells and abnormal mucosal nerve proliferations in Hirschsprung's disease. Hum Pathol (1988) 0.87
Insulin depletion leads to adipose-specific cell death in obese but not lean mice. Proc Natl Acad Sci U S A (1998) 0.87
Polypoid squamous carcinoma of the esophagus. A case report with immunostaining for keratin. Am J Surg Pathol (1983) 0.86
Primary lymphomas of the liver. Report of six cases and review of the literature. Am J Clin Pathol (1987) 0.86
Diagnosis and treatment of anticoagulant-related adrenal hemorrhage. Am J Hematol (1981) 0.85
Oncofetal antigens in sacrococcygeal teratomas. Arch Pathol Lab Med (1983) 0.85
Pregnancy-associated plasma protein A. A clinically significant predictor of early recurrence in stage I breast carcinoma is independent of estrogen receptor status. Am J Pathol (1985) 0.85
Pregnancy-associated plasma protein A and extensive necrosis. Clinically significant predictors of early recurrence in stage I estrogen receptor-negative breast carcinoma. Lab Invest (1985) 0.84
A novel intradural extramedullary spinal cord tumor in young dogs. Acta Neuropathol (1988) 0.84
Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium. Int J Gynecol Pathol (1997) 0.84
Localized herpes simplex lymphadenitis. Am J Clin Pathol (1986) 0.83
Common leukocyte antigen staining of a primitive sarcoma. Cancer (1987) 0.82
Immunocytochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs. Vet Pathol (1987) 0.82
Thorotrast-associated hepatic leiomyosarcoma and cholangiocarcinoma in a single patient. Hum Pathol (1987) 0.81
Pregnancy-associated plasma protein A: a clinically significant predictor of early recurrence in stage II breast carcinoma. Hum Pathol (1985) 0.81
The clinical management of a normal contralateral breast in patients with lobular breast cancer. Ann Surg (1989) 0.81
A submucosal variant of Whipple's disease. Gastroenterology (1982) 0.80
Partial trisomy 6q, due to balanced maternal translocation (6;22) (q21; p13) or (q21; pter). Clin Genet (1981) 0.80
Two-site ELISA for the quantitative determination of fatty acid synthase. Clin Chim Acta (2001) 0.80
Gonadal morphology in patients receiving chemotherapy for leukemia. Evidence for reproductive potential and against a testicular tumor sanctuary. Am J Med (1982) 0.80
Pregnancy-specific beta-1 glycoprotein (SP-1) in breast carcinoma. Pathologic and clinical considerations. Cancer (1984) 0.80
Immunoperoxidase staining as a diagnostic aid for hepatocellular carcinoma. Mod Pathol (1989) 0.79
Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema. J Neurosurg (1991) 0.79
Adrenal cortico-medullary junction necrosis: a morphologic marker for hypotension. Am Heart J (1979) 0.79
Suprasellar germ cell tumors in the dog: a report of five cases and review of the literature. Acta Neuropathol (1988) 0.78
Fibrosarcoma in a patient with scleroderma. J Comput Tomogr (1987) 0.78
Merkel cell (small cell) carcinoma of the skin: immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasms. Histochem J (1986) 0.78
Clinicopathologic features in two cases of multiple myeloma. Retina (1987) 0.78
Prostate-specific acid phosphatase immunoreactivity in adenocarcinomas of the urinary bladder. Hum Pathol (1986) 0.78
Low attenuation nodal metastases in testicular carcinoma. J Comput Assist Tomogr (1983) 0.77
Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane. Am J Pathol (1985) 0.76
Adenoid cystic carcinoma of the prostate. A case report with immunoperoxidase staining for prostate-specific acid phosphatase and prostate-specific antigen. Am J Clin Pathol (1984) 0.76
Anaplastic transformation of verrucous carcinoma following radiotherapy. Am J Otolaryngol (1986) 0.75
A new biomarker in monitoring breast cancer: CA 549. J Clin Oncol (1988) 0.75
CA-549: immunohistochemistry and serum levels in breast carcinoma and other neoplasms. Ann Clin Lab Sci (1990) 0.75
Case report 345. Schwannoma of wrist. Skeletal Radiol (1986) 0.75
pp32 overexpression induces nuclear pleomorphism in rat prostatic carcinoma cells. Cell Prolif (1996) 0.75
Case report 493: Neuroblastoma of the left ilium with disseminated bony metastasis. Skeletal Radiol (1988) 0.75
Myocardial injury in patients with aortic stenosis. Am J Cardiovasc Pathol (1987) 0.75
Papillary adenocarcinomas of the prostate. An immunohistochemical study. Cancer (1984) 0.75