Associative learning elicits the formation of multiple-synapse boutons.

PubWeight™: 1.68‹?› | Rank: Top 3%

🔗 View Article (PMID 11466428)

Published in J Neurosci on August 01, 2001

Authors

Y Geinisman1, R W Berry, J F Disterhoft, J M Power, E A Van der Zee

Author Affiliations

1: Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA. yurig@northwestern.edu

Articles citing this

The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci (2012) 2.76

Associative memory formation increases the observation of dendritic spines in the hippocampus. J Neurosci (2003) 2.63

A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci U S A (2007) 1.55

FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons. Front Neuroanat (2015) 1.50

Structural plasticity and hippocampal function. Annu Rev Psychol (2010) 1.40

Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J (2007) 1.38

Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures. Proc Natl Acad Sci U S A (2005) 1.35

New spines, new memories. Mol Neurobiol (2004) 1.28

Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Front Integr Neurosci (2008) 1.26

Temporal requirement of C/EBPbeta in the amygdala following reactivation but not acquisition of inhibitory avoidance. Learn Mem (2007) 1.24

Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeys. J Neurosci (2011) 1.15

The basolateral nucleus of the amygdala is necessary to induce the opposing effects of stressful experience on learning in males and females. J Neurosci (2008) 1.14

Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens. Brain Res (2007) 1.11

Biobehavioral markers of adverse effect in fetal alcohol spectrum disorders. Neuropsychol Rev (2011) 1.07

Role of the serotonin 5-HT(2A) receptor in learning. Learn Mem (2003) 1.06

Aberrant restoration of spines and their synapses in L-DOPA-induced dyskinesia: involvement of corticostriatal but not thalamostriatal synapses. J Neurosci (2013) 1.06

Axospinous synaptic subtype-specific differences in structure, size, ionotropic receptor expression, and connectivity in apical dendritic regions of rat hippocampal CA1 pyramidal neurons. J Comp Neurol (2009) 1.06

Cranial irradiation alters dendritic spine density and morphology in the hippocampus. PLoS One (2012) 1.06

The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory. Learn Mem (2007) 1.03

Role of androgens and the androgen receptor in remodeling of spine synapses in limbic brain areas. Horm Behav (2007) 1.01

General and variable features of varicosity spacing along unmyelinated axons in the hippocampus and cerebellum. Proc Natl Acad Sci U S A (2002) 1.01

Postischemic PKC activation rescues retrograde and anterograde long-term memory. Proc Natl Acad Sci U S A (2009) 0.99

Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis. Exp Neurol (2007) 0.99

A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS One (2008) 0.99

Behavioral tagging of extinction learning. Proc Natl Acad Sci U S A (2012) 0.98

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) (2011) 0.97

Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization. Biol Psychiatry (2009) 0.96

Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse. Physiol Rev (2015) 0.95

Increasing SK2 channel activity impairs associative learning. J Neurophysiol (2012) 0.94

Eye-blink conditioning is associated with changes in synaptic ultrastructure in the rabbit interpositus nuclei. Learn Mem (2007) 0.91

Effects of aging and caloric restriction on dentate gyrus synapses and glutamate receptor subunits. Neurobiol Aging (2007) 0.90

Mechanism for long-term memory formation when synaptic strengthening is impaired. Proc Natl Acad Sci U S A (2011) 0.89

Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats. J Comp Neurol (2012) 0.87

Spike-based synaptic plasticity and the emergence of direction selective simple cells: simulation results. J Comput Neurosci (2002) 0.86

Transsynaptic EphB/Ephrin-B signaling regulates growth of presynaptic boutons required for classical conditioning. J Neurosci (2011) 0.86

Rapid enrichment of presynaptic protein in boutons undergoing classical conditioning is mediated by brain-derived neurotrophic factor. Neuroscience (2011) 0.86

Experience-dependent, rapid structural changes in hippocampal pyramidal cell spines. Cereb Cortex (2009) 0.85

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. Front Behav Neurosci (2013) 0.85

Specialized pathways from the primate amygdala to posterior orbitofrontal cortex. J Neurosci (2014) 0.84

Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens. Neuropharmacology (2014) 0.82

Age-Induced Alterations in Hippocampal Function and Metabolism. Aging Dis (2011) 0.82

K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration. Front Pharmacol (2012) 0.82

Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms. Front Neurosci (2016) 0.81

Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J Neurosci (2013) 0.81

The long-term structural plasticity of cerebellar parallel fiber axons and its modulation by motor learning. J Neurosci (2013) 0.81

Old Dogs Learning New Tricks: Neuroplasticity Beyond the Juvenile Period. Dev Rev (2011) 0.80

Retrieval of contextual memories increases activity-regulated cytoskeleton-associated protein in the amygdala and hippocampus. Brain Struct Funct (2012) 0.80

Enduring medial perforant path short-term synaptic depression at high pressure. Front Cell Neurosci (2010) 0.79

Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials. Psychopharmacology (Berl) (2013) 0.78

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells. Cereb Cortex (2016) 0.78

Chronic desipramine prevents acute stress-induced reorganization of medial prefrontal cortex architecture by blocking glutamate vesicle accumulation and excitatory synapse increase. Int J Neuropsychopharmacol (2014) 0.78

Selective developmental increase in the climbing fiber input to the cerebellar interpositus nucleus in rats. Behav Neurosci (2004) 0.78

Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys. J Neurosci (2016) 0.78

Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons. Neuropsychopharmacology (2016) 0.77

Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons. Brain Struct Funct (2014) 0.77

Characterization of MSB synapses in dissociated hippocampal culture with simultaneous pre- and postsynaptic live microscopy. PLoS One (2011) 0.76

Training-dependent associative learning induced neocortical structural plasticity: a trace eyeblink conditioning analysis. PLoS One (2014) 0.76

Effects of context-drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats. Eur J Neurosci (2014) 0.76

Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease. Behav Brain Res (2016) 0.76

Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage. J Med Life (2015) 0.75

Structural and functional plasticity of dendritic spines - root or result of behavior? Genes Brain Behav (2016) 0.75

The Role of Ephs and Ephrins in Memory Formation. Int J Neuropsychopharmacol (2016) 0.75

Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough. Dev Psychobiol (2011) 0.75

Articles by these authors

Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals. Gene Ther (2008) 2.93

Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav Neurosci (1990) 2.91

Interactions of tubulin with vinblastine and guanosine triphosphate. J Mol Biol (1972) 2.49

Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat. Hippocampus (1998) 2.19

Trace eyeblink conditioning increases CA1 excitability in a transient and learning-specific manner. J Neurosci (1996) 2.13

Cortical involvement in acquisition and extinction of trace eyeblink conditioning. Behav Neurosci (2000) 1.78

Lesions of the caudal area of rabbit medial prefrontal cortex impair trace eyeblink conditioning. Neurobiol Learn Mem (1998) 1.68

Hippocampal lesions prevent trace eyeblink conditioning in the freely moving rat. Behav Brain Res (1999) 1.67

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci (2000) 1.67

Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro. Proc Natl Acad Sci U S A (1986) 1.57

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. J Neurophysiol (1992) 1.56

Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses. J Neurophysiol (1997) 1.48

In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. Biochemistry (2000) 1.46

Ventricular containment as an adjunctive procedure in ischemic caridomyopathy: early results. Ann Thorac Surg (2000) 1.39

Nimodipine facilitates associative learning in aging rabbits. Science (1989) 1.32

Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning. J Neurosci (2000) 1.31

Intact delay-eyeblink classical conditioning in amnesia. Behav Neurosci (1995) 1.30

Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation. J Neurophysiol (1996) 1.30

Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia. Behav Neurosci (1997) 1.29

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol Aging (2004) 1.29

Hippocampal encoding of non-spatial trace conditioning. Hippocampus (1999) 1.20

Trace eyeblink conditioning is hippocampally dependent in mice. Hippocampus (2004) 1.17

Awareness in classical differential eyeblink conditioning in young and aging humans. Behav Neurosci (2001) 1.17

Functional mapping of human learning: a positron emission tomography activation study of eyeblink conditioning. J Neurosci (1996) 1.15

Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature (1992) 1.13

A system for quantitative analysis of associative learning. Part 1. Hardware interfaces with cross-species applications. J Neurosci Methods (1994) 1.12

Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem (2001) 1.11

fMRI of visual system activation in the conscious rabbit. Magn Reson Med (2000) 1.11

The cholinergic system, circadian rhythmicity, and time memory. Behav Brain Res (2010) 1.10

Age- and dose-dependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits. Behav Neurosci (1997) 1.10

A sodium dodecyl sulfate--polyacrylamide gel electrophoresis system that separates peptides and proteins in the molecular weight range of 2500 to 90,000. Anal Biochem (1983) 1.10

Activity of hippocampal pyramidal neurons during trace eyeblink conditioning. Hippocampus (1996) 1.09

Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat. Neurobiol Aging (2001) 1.08

Trace eyeblink conditioning in the freely moving rat: optimizing the conditioning parameters. Behav Neurosci (1999) 1.08

Remodeling of hippocampal synapses after hippocampus-dependent associative learning. J Comp Neurol (2000) 1.07

Oxidative regulation of fatty acid-induced tau polymerization. Biochemistry (2000) 1.07

Comparisons of dorsal and ventral hippocampus cornu ammonis region 1 pyramidal neuron activity during trace eye-blink conditioning in the rabbit. Neuroscience (2006) 1.07

The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons. J Neurosci (2000) 1.06

Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease. Neurobiol Aging (2009) 1.06

Learning centers of rat brain mapped by measuring latencies of conditioned unit responses. J Neurophysiol (1972) 1.05

Conditioning, awareness, and the hippocampus. Hippocampus (1998) 1.04

Connections of the caudal anterior cingulate cortex in rabbit: neural circuitry participating in the acquisition of trace eyeblink conditioning. Neuroscience (2007) 1.04

Synapses with a segmented, completely partitioned postsynaptic density express more AMPA receptors than other axospinous synaptic junctions. Neuroscience (2004) 1.04

Eyeblink conditioning in the rabbit (Oryctolagus cuniculus) with stimulation of the mystacial vibrissae as a conditioned stimulus. Behav Neurosci (2001) 1.03

Neurotoxic lesions of the dorsal hippocampus disrupt auditory-cued trace heart rate (fear) conditioning in rabbits. Hippocampus (2000) 1.03

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE. Mol Psychiatry (2005) 1.02

Differential development of conditioned unit changes in thalamus and cortex of rat. J Neurophysiol (1972) 1.00

Classical conditioning reduces amplitude and duration of calcium-dependent afterhyperpolarization in rabbit hippocampal pyramidal cells. J Neurophysiol (1989) 1.00

Aging and learning-specific changes in single-neuron activity in CA1 hippocampus during rabbit trace eyeblink conditioning. J Neurophysiol (2001) 0.99

Enhanced synaptic transmission in CA1 hippocampus after eyeblink conditioning. J Neurophysiol (1997) 0.98

Activation of neurosecretory cells enhances their synthesis of secretory protein. Brain Res (1981) 0.98

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience (2011) 0.98

Learning-induced alterations in hippocampal PKC-immunoreactivity: a review and hypothesis of its functional significance. Prog Neuropsychopharmacol Biol Psychiatry (1997) 0.97

Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine. Neuroscience (2000) 0.97

Trace eyeblink conditioning in rabbits demonstrates heterogeneity of learning ability both between and within age groups. Neurobiol Aging (1996) 0.96

Ribonucleic acid metabolism of a single neuron: correlation with electrical activity. Science (1969) 0.95

Response plasticity of single neurons in rabbit auditory association cortex during tone-signalled learning. Brain Res (1982) 0.94

N-methyl-D-aspartate receptors in associative eyeblink conditioning: both MK-801 and phencyclidine produce task- and dose-dependent impairments. J Pharmacol Exp Ther (1997) 0.94

Spared discrimination and impaired reversal eyeblink conditioning in patients with temporal lobe amnesia. Behav Neurosci (2001) 0.92

Nictitating membrane conditioning to tone in the immobilized albino rabbit. Brain Res (1977) 0.92

Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. J Neurosci (1999) 0.91

Metrifonate improves associative learning and retention in aging rabbits. Behav Neurosci (1997) 0.91

Dynamics in the ultrastructure of asymmetric axospinous synapses in the frontal cortex of hibernating European ground squirrels (Spermophilus citellus). Synapse (2007) 0.90

Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner. Hippocampus (1994) 0.90

Animal models of brain dysfunction in phenylketonuria. Mol Genet Metab (2010) 0.89

Trial sequence of changed unit activity in auditory system of alert rat during conditioned response acquisition and extinction. J Neurophysiol (1976) 0.89

Gradual reappearance of post-hibernation circadian rhythmicity correlates with numbers of vasopressin-containing neurons in the suprachiasmatic nuclei of European ground squirrels. J Comp Physiol B (2002) 0.89

Impaired delay eyeblink conditioning in amnesic Korsakoff's patients and recovered alcoholics. Alcohol Clin Exp Res (1995) 0.89

gamma Isoform-selective changes in PKC immunoreactivity after trace eyeblink conditioning in the rabbit hippocampus. Hippocampus (1997) 0.89

Learning and memory. FESN Study Group. Brain Res Brain Res Rev (1992) 0.89

Hippocampal unit activity during classical aversive and appetitive conditioning. Science (1972) 0.88

Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits. Behav Neurosci (1989) 0.88

Metrifonate decreases sI(AHP) in CA1 pyramidal neurons in vitro. J Neurophysiol (2001) 0.88

Chronic but not acute foot-shock stress leads to temporary suppression of cell proliferation in rat hippocampus. Neuroscience (2009) 0.88

Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice. Neurobiol Dis (2002) 0.88

A system for quantitative analysis of associative learning. Part 2. Real-time software for MS-DOS microcomputers. J Neurosci Methods (1994) 0.87

Temporal discrimination learning in severe amnesic patients reveals an alteration in the timing of eyeblink conditioned responses. Behav Neurosci (1999) 0.86

Combined endocardial and epicardial radiofrequency ablation of right and left atria in the treatment of atrial fibrillation. Ann Thorac Surg (2001) 0.86

Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus. J Neurophysiol (1993) 0.86

Age-related loss of calcium binding proteins in rabbit hippocampus. Neurobiol Aging (1996) 0.85

Functional correlates of low molecular weight peptide synthesis in Aplysia neurons. Brain Res (1975) 0.85

Axonal transport and axonal processing of low molecular weight proteins from the abdominal ganglion of Aplysia. Brain Res (1977) 0.84

Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging. Neuroimage (2002) 0.84

Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. Brain Res (1990) 0.83

Neuronal morphology of the rabbit cochlear nucleus. J Comp Neurol (1980) 0.83

Cholinergic facilitation of trace eyeblink conditioning in aging rabbits. Life Sci (1999) 0.83

17beta-estradiol enhances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis. Neuroscience (2002) 0.82

A comparison of the 12,000 dalton proteins synthesized by Aplysia neurons L11 and R15. Brain Res (1976) 0.82

Left ventricular pseudoaneurysm secondary to cardiac stab wound. Successful repair in a thirteen-year-old girl. Am J Cardiol (1965) 0.82