Published in Nat Struct Biol on August 01, 2001
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. J Biol Chem (2009) 1.08
The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proc Natl Acad Sci U S A (2002) 1.02
Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Antimicrob Agents Chemother (2004) 1.00
Characterization of LtsA from Rhodococcus erythropolis, an enzyme with glutamine amidotransferase activity. J Bacteriol (2005) 0.99
The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus. J Bacteriol (2004) 0.94
Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. Biochem J (2002) 0.93
Osmotically induced synthesis of the dipeptide N-acetylglutaminylglutamine amide is mediated by a new pathway conserved among bacteria. Proc Natl Acad Sci U S A (2010) 0.92
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster. Biochem J (2005) 0.90
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry (2009) 0.88
Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase. Biochemistry (2007) 0.86
A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis. Chembiochem (2009) 0.84
Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem (2010) 0.83
Convergent biosynthetic pathways to β-lactam antibiotics. Curr Opin Chem Biol (2016) 0.79
5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Antimicrob Agents Chemother (2012) 0.78
Biosynthesis of clavam metabolites. J Ind Microbiol Biotechnol (2012) 0.77
Identification and characterization of a NaCl-responsive genetic locus involved in survival during desiccation in Sinorhizobium meliloti. Appl Environ Microbiol (2013) 0.75
Transposon mutagenesis of probiotic Lactobacillus casei identifies asnH, an asparagine synthetase gene involved in its immune-activating capacity. PLoS One (2014) 0.75
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry (2010) 0.75
Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics. Medchemcomm (2012) 0.75
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science (2000) 4.62
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol (2000) 4.59
Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea. Proc Natl Acad Sci U S A (2010) 4.12
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Nature (1995) 3.67
Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci U S A (2000) 2.93
Heterodimeric structure of superoxide dismutase in complex with its metallochaperone. Nat Struct Biol (2001) 2.67
Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. Nat Struct Biol (2000) 2.26
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res (2000) 2.21
Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers. Infect Immun (2001) 1.61
Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. Biochemistry (1990) 1.58
Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. J Am Chem Soc (2001) 1.53
beta-Lactam synthetase: a new biosynthetic enzyme. Proc Natl Acad Sci U S A (1998) 1.39
Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry (1992) 1.34
Stereochemistry of methyl group insertion in corrinoid biosynthesis. Determination of carbon isotope chirality by 13C nuclear magnetic resonance. J Am Chem Soc (1973) 1.23
Structure of the bacteriophage lambda Ser/Thr protein phosphatase with sulfate ion bound in two coordination modes. Biochemistry (2000) 1.20
Crystal structure of the copper chaperone for superoxide dismutase. Nat Struct Biol (1999) 1.19
Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1. Chem Biol (1996) 1.19
Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer. Proc Natl Acad Sci U S A (2001) 1.18
Structure-function analyses of the ATX1 metallochaperone. J Biol Chem (1999) 1.16
Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase. Biochemistry (2001) 1.16
Heterodimer formation between superoxide dismutase and its copper chaperone. Biochemistry (2000) 1.09
Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis. J Biol Chem (1998) 1.09
Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. J Bacteriol (1995) 1.08
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster. J Biol Chem (1996) 1.06
Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase. J Am Chem Soc (2001) 1.05
A new class of antituberculosis agents. J Med Chem (2000) 1.03
Cleavage by calicheamicin gamma 1I of DNA in a nucleosome formed on the 5S RNA gene of Xenopus borealis. Biochemistry (1995) 1.02
Sequencing and analysis of the Mmethylococcus capsulatus (Bath) solublemethane monooxygenase genes. Eur J Biochem (2000) 1.02
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. Bioorg Chem (2001) 1.00
Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. J Bacteriol (2000) 0.99
Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus. Biochemistry (2000) 0.97
Crystal structure of a novel red copper protein from Nitrosomonas europaea. Biochemistry (2001) 0.97
A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations. Bioorg Med Chem (1996) 0.96
Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Appl Environ Microbiol (2000) 0.96
Biosynthesis of corrins. I. Experiments with 14-C porphobilinogen and 14-C uroporphyrinogens. J Am Chem Soc (1974) 0.96
Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry (1991) 0.95
Crystal structure of the second domain of the human copper chaperone for superoxide dismutase. Biochemistry (2000) 0.93
Concerning the biosynthesis of vitamin B12. Trans N Y Acad Sci (1973) 0.93
Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. J Biol Chem (1995) 0.90
Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis. J Biol Chem (1995) 0.88
Hydroxyl radical footprinting of calicheamicin. Relationship of DNA binding to cleavage. Biochemistry (1994) 0.87
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway. J Biol Chem (1997) 0.86
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochemistry (1996) 0.86
Biosynthesis of corrins. II. Incorporation of 13C-labeled substrates in vitamins B12. J Am Chem Soc (1974) 0.85
Changes in donor corneal lenticule thickness after Descemet's stripping automated endothelial keratoplasty (DSAEK) with organ-cultured corneas. Br J Ophthalmol (2009) 0.81
Letter: Concerning the intermediacy of uro'gen III and of a heptacarboxylic uro'gen in corrinoid biosynthesis. J Am Chem Soc (1975) 0.81
Nuclear hyperfine coupling of nitrogen in the coordination sphere of the diiron center of methane monooxygenase hydroxylase. J Biol Chem (1994) 0.81
Nitrous oxide reductase from CuA to CuZ. Nat Struct Biol (2000) 0.78
Biosynthesis of corrinoids. Uroporphyrinogen 3 as a precrusor of vitamin B 12 . J Am Chem Soc (1972) 0.78
Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model. Biochemistry (2000) 0.77
The stereochemical fate of chiral-methyl valines in cephalosporin C biosynthesis. J Nat Prod (1986) 0.75
Measurement of the degree of coupled isotopic enrichment of different positions in an antibiotic peptide by NMR. J Magn Reson (1997) 0.75
Biosynthesis of corrinoids. Concerning ithe origin of the methyl groups in vitamin B 12 . J Am Chem Soc (1972) 0.75
Is the enemy among us? It's my opinion. Ohio Nurses Rev (1996) 0.75
A good CV will help your career take off. RN (1992) 0.75
Hemoptysis in sarcoidosis. Sarcoidosis (1987) 0.75
Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase. J Nat Prod (1993) 0.75